Novel Approaches for the Control of Microbial Pathogens

控制微生物病原体的新方法

• 批准号: 8304608
• 负责人: Joseph F Lutkenhaus
• 金额: $ 109.47万
• 依托单位: UNIVERSITY OF KANSAS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8304608
• 关键词: Address; Administrator; American Cancer Society; Applications Grants; Appointment; Area; Award; Bacteriology; Bioinformatics; Cancer Center; Cell Separation; Centers of Research Excellence; Cities; Collaborations; Communicable Diseases; Critiques; Data; Data Analyses; Electron Microscopy; Ensure; Environment; Equipment; Faculty; Fee-for-Service Plans; Flow Cytometry; Foundations; Funding; Funding Agency; Future; Gene Targeting; Goals; Grant; Health; Heart; Housing; Human; Human Resources; Image; Individual; Institutes; Institution; Investigation; Kansas; Laboratories; Laboratory Animals; Letters; Manuscripts; Mass Spectrum Analysis; Medical; Medical center; Medicine; Mentors; Microbiology; Molecular Genetics; Molecular Immunology; Nursing Faculty; Paper; Pathogenesis; Phase; Philosophy; Pilot Projects; Positioning Attribute; Preparation; Program Research Project Grants; Proteomics; Recording of previous events; Request for Applications; Research; Research Personnel; Research Support; Services; System; Technology; Training; Transgenic Organisms; United States National Institutes of Health; Universities; Viral; Vision; Wages; Writing; animal resource; base; experience; hazard; high throughput screening; human disease; improved; innovation; instrumentation; meetings; member; microbial; microorganism; novel strategies; pathogen; programs; protein structure; research study; square foot; success; tool; virology

DESCRIPTION (provided by applicant): In this application we are requesting funds to continue our COBRE Center, Novel Approaches for the Control of Microbial Pathogens, for five more years. Our COBRE was first funded in 2001 and then renewed in 2006. The objective of the center was to promote and to enhance the research capabilities of tenure track junior faculty members of participating institutions in the state of Kansas with emphasis on inhibiting microbial pathogens. The program has been highly successful during the first ten years with the awarding of 34 Project and faculty enhancement awards. 34 tenure track faculty have received awards and investigators supported by COBRE have obtained 46 NIH grants (19 R01's, 12 R21's, 8 R03's and 1 U01 in addition to 2 R56 1 K01, 2 K22 and 1 SC3) resulting in a total of about $40 million in new funding for the state of Kansas. An essential part of the COBRE was the establishment of a flow cytometry research core. The Flow core lab is equipped with state-of-the-art instrumentation and the personnel have extensive experience in cell-sorting and flow analysis. The primary goal of the flow core has been to make the instrumentation and technical tools available to biomedical researchers in the Greater Kansas City area but primarily at the University of Kansas Medical Center. It is housed in a 775 sq ft lab that has recently been expanded and enhanced for biosafety. The primary tasks of the core are to 1) educate investigators about the technology, 2) train individuals in the use of the equipment, 3) carry out cell sorting and flow analyses for those investigators who do not want to be trained on the equipment, 4) assist in the planning of experiments, especially for clinical faculty, and 5) aide in data analysis and figure preparation. In Phase III we are requesting funds to continue the very successful flow core and to make it self-sustaining by the end of the 5-year funding period. We also seek support for an administrative core that will oversee the entire program and provide assistance for grant applications. This core also contains a valuable writing core to aide in grant and manuscript preparation. In addition, we seek support for a Pilot Project program to provide support for research investigators to obtain preliminary data to strengthen their applications to federal agencies for funding. PUBLIC HEALTH RELEVANCE (provided by applicant): Despite progress made in the study of infectious diseases they still pose a major hazard to human health. This proposal provides support for pilot projects and core research and administrative facilities to enhance investigation into the control of a variety of viral and bacterial microorganisms that cause human disease.

描述（由申请人提供）：在本申请中，我们请求资金以继续我们的 COBRE 中心“控制微生物病原体的新方法”五年。我们的 COBRE 于 2001 年首次获得资助，并于 2006 年更新。该中心的目标是促进和提高堪萨斯州参与机构的终身教授初级教员的研究能力，重点是抑制微生物病原体。该计划在前十年取得了巨大成功，颁发了 34 个项目和教师增强奖。 34 名终身教授获得了奖励，COBRE 支持的研究人员获得了 46 项 NIH 拨款（19 项 R01、12 项 R21、8 项 R03 和 1 项 U01，以及 2 项 R56、1 K01、2 K22 和 1 SC3），为堪萨斯州提供了总计约 4000 万美元的新资金。 COBRE 的一个重要组成部分是流式细胞术研究核心的建立。 Flow核心实验室配备了最先进的仪器，人员在细胞分选和流式分析方面拥有丰富的经验。流程核心的主要目标是为大堪萨斯城地区（主要是堪萨斯大学医学中心）的生物医学研究人员提供仪器和技术工具。它坐落在一个 775 平方英尺的实验室中，该实验室最近为了生物安全而进行了扩建和增强。核心的主要任务是 1) 对研究人员进行技术教育，2) 对人员进行培训 设备的使用，3) 为那些不想接受设备培训的研究人员进行细胞分选和流式分析，4) 协助实验规划，特别是临床教师，以及 5) 协助数据分析和图形准备。 在第三阶段，我们请求资金来继续非常成功的流程核心，并使其在 5 年资助期结束时能够自我维持。我们还寻求对行政核心的支持，该核心将监督整个计划并为拨款申请提供帮助。该核心还包含一个有价值的写作核心，以帮助资助和手稿准备。此外，我们寻求对试点项目计划的支持，为研究人员提供支持，以获得初步数据，以加强他们向联邦机构的资助申请。 公共卫生相关性（由申请人提供）：尽管传染病研究取得了进展，但它们仍然对人类健康构成重大危害。该提案为试点项目以及核心研究和行政设施提供支持，以加强调查 控制引起人类疾病的多种病毒和细菌微生物。