Novel Approaches for the Control of Microbial Pathogens

描述（由申请人提供）：在本申请中，我们要求资金继续我们的COBRE中心，微生物病原体控制的新方法，五年以上。我们的COBRE于2001年首次获得资助，并于2006年获得更新。该中心的目标是促进和提高堪萨斯州参与机构的终身教职初级教员的研究能力，重点是抑制微生物病原体。该计划在前十年取得了巨大的成功，获得了34个项目和教师提高奖。34个终身教职教师获得了奖项，由COBRE支持的研究人员获得了46个NIH赠款（19个R01，12个R21，8个R03和1个U01，以及2个R56 1 K01，2个K22和1个SC3），为堪萨斯州提供了总计约4000万美元的新资金。 COBRE的一个重要组成部分是建立流式细胞术研究核心。Flow核心实验室配备了最先进的仪器，工作人员在细胞分选和流动分析方面拥有丰富的经验。流动核心的主要目标是使仪器和技术工具提供给大堪萨斯城地区的生物医学研究人员，但主要是在堪萨斯大学医学中心。它位于一个775平方英尺的实验室内，该实验室最近经过扩建和增强，以确保生物安全。核心的主要任务是1）教育调查人员了解技术，2）培训个人 设备的使用，3）为那些不想接受设备培训的研究人员进行细胞分选和流动分析，4）协助实验计划，特别是临床教师，以及5）协助数据分析和图表准备。 在第三阶段，我们正在请求资金来继续非常成功的流程核心，并在5年资助期结束时使其能够自我维持。我们还寻求对一个行政核心的支持，该核心将监督整个计划并为赠款申请提供帮助。这个核心还包含一个有价值的写作核心，以帮助赠款和手稿的准备。此外，我们寻求对试点项目计划的支持，为研究调查人员提供支持，以获得初步数据，以加强他们向联邦机构申请资金。

DESCRIPTION (provided by applicant): In this application we are requesting funds to continue our COBRE Center, Novel Approaches for the Control of Microbial Pathogens, for five more years. Our COBRE was first funded in 2001 and then renewed in 2006. The objective of the center was to promote and to enhance the research capabilities of tenure track junior faculty members of participating institutions in the state of Kansas with emphasis on inhibiting microbial pathogens. The program has been highly successful during the first ten years with the awarding of 34 Project and faculty enhancement awards. 34 tenure track faculty have received awards and investigators supported by COBRE have obtained 46 NIH grants (19 R01's, 12 R21's, 8 R03's and 1 U01 in addition to 2 R56 1 K01, 2 K22 and 1 SC3) resulting in a total of about $40 million in new funding for the state of Kansas. An essential part of the COBRE was the establishment of a flow cytometry research core. The Flow core lab is equipped with state-of-the-art instrumentation and the personnel have extensive experience in cell-sorting and flow analysis. The primary goal of the flow core has been to make the instrumentation and technical tools available to biomedical researchers in the Greater Kansas City area but primarily at the University of Kansas Medical Center. It is housed in a 775 sq ft lab that has recently been expanded and enhanced for biosafety. The primary tasks of the core are to 1) educate investigators about the technology, 2) train individuals in the use of the equipment, 3) carry out cell sorting and flow analyses for those investigators who do not want to be trained on the equipment, 4) assist in the planning of experiments, especially for clinical faculty, and 5) aide in data analysis and figure preparation. In Phase III we are requesting funds to continue the very successful flow core and to make it self-sustaining by the end of the 5-year funding period. We also seek support for an administrative core that will oversee the entire program and provide assistance for grant applications. This core also contains a valuable writing core to aide in grant and manuscript preparation. In addition, we seek support for a Pilot Project program to provide support for research investigators to obtain preliminary data to strengthen their applications to federal agencies for funding.