Novel Approaches for the Control of Microbial Pathogens

描述(由申请人提供)：在这份申请中，我们申请资金继续我们的科布雷中心，微生物病原体控制的新方法，再持续五年。我们的Cobre在2001年首次获得资金，然后在2006年续签。该中心的目标是促进和加强堪萨斯州参与机构的终身教职初级教员的研究能力，重点是抑制微生物病原体。该计划在头十年非常成功，颁发了34个项目和教师增强奖。34名终身教职员工获得了奖项，科布雷支持的研究人员获得了46笔NIH拨款(19笔R01的S、12笔R21的S、8笔R03的S和1笔U01以及2笔R56、1笔K01、2笔K22和1笔SC3)，为堪萨斯州带来了总计约4,000万美元的新资金。 Cobre的一个重要部分是建立一个流式细胞仪研究核心。Flow核心实验室配备了最先进的仪器设备，人员在细胞分选和流动分析方面拥有丰富的经验。FLOW核心的主要目标是向大堪萨斯城地区的生物医学研究人员提供仪器和技术工具，但主要是在堪萨斯大学医学中心。它被安置在一个775平方英尺的实验室里，最近为了生物安全而进行了扩建和增强。核心的主要任务是1)教育调查人员有关技术，2)培训个人在 使用设备，3)为那些不想接受设备培训的研究人员进行细胞分选和流动分析，4)协助实验计划，特别是临床教师，以及5)协助数据分析和图形准备。 在第三阶段，我们正在申请资金，以继续非常成功的流动核心，并使其在5年期结束时能够自给自足。我们还寻求对行政核心的支持，该核心将监督整个计划，并为拨款申请提供帮助。这个核心还包含一个宝贵的写作核心，以帮助赠款和手稿准备。此外，我们寻求对一个试点项目的支持，该项目旨在为研究人员提供支持，以获得初步数据，以加强他们向联邦机构申请资金的能力。

DESCRIPTION (provided by applicant): In this application we are requesting funds to continue our COBRE Center, Novel Approaches for the Control of Microbial Pathogens, for five more years. Our COBRE was first funded in 2001 and then renewed in 2006. The objective of the center was to promote and to enhance the research capabilities of tenure track junior faculty members of participating institutions in the state of Kansas with emphasis on inhibiting microbial pathogens. The program has been highly successful during the first ten years with the awarding of 34 Project and faculty enhancement awards. 34 tenure track faculty have received awards and investigators supported by COBRE have obtained 46 NIH grants (19 R01's, 12 R21's, 8 R03's and 1 U01 in addition to 2 R56 1 K01, 2 K22 and 1 SC3) resulting in a total of about $40 million in new funding for the state of Kansas. An essential part of the COBRE was the establishment of a flow cytometry research core. The Flow core lab is equipped with state-of-the-art instrumentation and the personnel have extensive experience in cell-sorting and flow analysis. The primary goal of the flow core has been to make the instrumentation and technical tools available to biomedical researchers in the Greater Kansas City area but primarily at the University of Kansas Medical Center. It is housed in a 775 sq ft lab that has recently been expanded and enhanced for biosafety. The primary tasks of the core are to 1) educate investigators about the technology, 2) train individuals in the use of the equipment, 3) carry out cell sorting and flow analyses for those investigators who do not want to be trained on the equipment, 4) assist in the planning of experiments, especially for clinical faculty, and 5) aide in data analysis and figure preparation. In Phase III we are requesting funds to continue the very successful flow core and to make it self-sustaining by the end of the 5-year funding period. We also seek support for an administrative core that will oversee the entire program and provide assistance for grant applications. This core also contains a valuable writing core to aide in grant and manuscript preparation. In addition, we seek support for a Pilot Project program to provide support for research investigators to obtain preliminary data to strengthen their applications to federal agencies for funding.