Novel Approaches for the Control of Microbial Pathogens

描述（由申请人提供）：要求五年的支持，以创建一个教师发展计划，使参与研究的初级教师在堪萨斯州的三个博士学位授予机构（堪萨斯大学劳伦斯分校、堪萨斯城的堪萨斯大学医学院和堪萨斯州立大学）变得更具竞争力，以获得NIH的资助支持，并招募可以开发新研究项目的高级教师。将建立一个由Narayan博士和个别项目导师组成的强有力的指导计划，他们都是既定的调查员，一个旨在协助COBRE成员准备手稿和赠款的写作计划，以及一个每年两次审查所有项目进展的外部咨询委员会。五个核心，一个行政，一个专注于写作，三个技术，已经在本COBRE的最后一年建立，以加快新的研究计划。COBRE得到了广泛的新的机构支持，包括全职员工和三个技术核心的新研究设备。研究主题集中在旨在抑制病原微生物复制的基础和转化机制。研究将集中在微生物基因和基因产物的鉴定上，这些基因和基因产物在它们的复制中起着重要作用，并将它们用作治疗目标。COBRE的翻译部分将专门用于使用纳米颗粒作为体内递送载体的基因治疗。COBRE的资助将用于支持四名初级教员和一名高级教员的三年项目，为三所大学加强新教员的招聘计划提供资金，并为进一步招聘有助于发展新研究项目的高级教员提供资金。资金还将用于运行由最先进的流式细胞术、信号转导和Luminex技术组成的三个技术核心，这将有助于快速分析感染引起的宿主反应基因产物。目前选定教师的项目是基于科学价值，由外部咨询委员会成员审查，重点是与其他项目的互补互动，发展成由高级教师领导的新研究项目的潜力，以及获得NIH资助支持的可能性。其中两个技术核心将由两名教师指导，他们之前得到了COBRE的支持，并分别获得了NIH的两项资助。新项目的开发是为了响应新的RFA，该RFA建议招聘高级教师，以帮助开发和领导新的研究项目。一名这样的高级教员已经被招募。最后，新项目以我们的记录为基础，上届COBRE支持的11名研究人员总共获得了16项校外资助。11人中有8人获得了12项NIH资助。

DESCRIPTION (provided by applicant): Five years of support are requested to create a faculty development program that will enable junior faculty involved in research at the three Ph.D. granting institutions in Kansas (KU at Lawrence and the KU School of Medicine in Kansas City, and Kansas State University) to become more competitive for securing NIH grant support and to recruit senior faculty who could develop new research programs. A strong mentoring program comprised of Dr. Narayan and individual Project mentors, all of whom are established investigators, a writing program designed to assist COBRE members in preparation of manuscripts and grants, and an external advisory committee who will review progress of all Projects twice annually will be established. Five Cores, one administrative, one focused on writing, and three technical, have already been established in the final year of the present COBRE to expedite the new research program. The COBRE has received extensive new institutional support in the form of FTEs and new research equipment in the three technical Cores. The research theme is centered on basic and translational mechanisms aimed at inhibiting replication of pathogenic microbes. Studies will be focused on identification of microbial genes and gene products that have a seminal role in their replication and use of these as targets for therapy. The translational portion of the COBRE will be dedicated to use of gene therapy using nanoparticles as vectors for delivery in vivo. The COBRE support will be used to support three-year Projects of four junior faculty and one senior faculty, funds for enhancement of recruitment packages of new faculty at the three institutions, and funds for further recruitment of senior faculty who could contribute to development of new research programs. Funds will also be used to operate the three technical Cores comprised of state-of-the-art flow cytometry, signal transduction, and Luminex technology, which will facilitate rapid analysis of host response gene products resulting from infection. The Projects of currently selected faculty were based on scientific merit, review by External Advisory Committee members, with a focus for complementary interaction with other Projects, potential for development into new research programs headed by senior faculty, and likelihood for receiving NIH grant support. Two of the technical Cores will be directed by two faculty members who were previously supported by the COBRE and who have each secured two NIH grants. The new program was developed in response to the new RFA that suggested recruitment of senior faculty who could help develop and head new research programs. One such senior faculty has already been recruited. Finally, the new program has been based on our track record in which eleven investigators supported by the previous COBRE have secured a total of 16 extramural grants. Eight of the eleven have secured 12 NIH grants.