CTSU resubmission: Proposal to increase capacity for methodological improvements in clinical trials

CTSU 重新提交：提高临床试验方法改进能力的提案

• 批准号: MC_EX_G0801669
• 负责人: Rory Collins
• 金额: $ 241.56万
• 依托单位: Medical Research Council
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_EX_G0801669
• 关键词: CTSU; resubmission; Proposal; increase; capacity

Oxford University?s Clinical Trial Service Unit already provides methodological advice across the different phases of major clinical trials (design, conduct, analysis and interpretation) to a large number of research groups in Oxford, elsewhere in the UK and internationally. It aims to improve the quality of these trials (e.g. more patients recruited more rapidly; better data quality and study conduct) in order that they generate more reliable evidence about the effects of treatments on mortality and major morbidity. MRC hub funding would be used by the CTSU to increase its leadership role in two main areas. Firstly, providing guidance to clinical experts on the design and conduct of trials (chiefly in vascular and neoplastic diseases); and, secondly, developing efficient and secure IT systems to facilitate the conduct of large-scale trials. More reliable evidence from better trials should lead to substantial improvements in public health.

牛津大学？牛津大学的临床试验服务部门已经为牛津大学、英国其他地方和国际上的大量研究小组提供了主要临床试验不同阶段（设计、实施、分析和解释）的方法学建议。它旨在提高这些试验的质量（例如，更快地招募更多患者;更好的数据质量和研究实施），以便它们产生关于治疗对死亡率和主要发病率影响的更可靠证据。技术支助股将利用MRC中心的资金加强其在两个主要领域的领导作用。首先，为临床专家提供试验设计和实施方面的指导（主要是血管和肿瘤疾病）;其次，开发高效、安全的IT系统，以促进大规模试验的实施。来自更好的试验的更可靠的证据应该会导致公共卫生的实质性改善。

项目成果

Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults.

• DOI: 10.1038/s43856-022-00208-2
• 发表时间: 2022-11-14
• 期刊: COMMUNICATIONS MEDICINE
• 作者: Aguilar-Ramirez, Diego;Herrington, William G.;Alegre-Diaz, Jesus;Staplin, Natalie;Ramirez-Reyes, Raul;Gnatiuc, Louisa Friedrichs;Hill, Michael;Romer, Frederik;Trichia, Eirini;Bragg, Fiona;Wade, Rachel;Lewington, Sarah;Collins, Rory;Emberson, Jonathan R.;Kuri-Morales, Pablo;Tapia-Conyer, Roberto
• 通讯作者: Tapia-Conyer, Roberto

Benefits of lowering cholesterol in chronic kidney disease - Authors' reply

降低胆固醇对慢性肾病的好处 - 作者的回复

• DOI: 10.1016/s0140-6736(11)61608-5
• 发表时间: 2011
• 期刊: The Lancet
• 作者: Baigent C

Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study.

• DOI: 10.1016/s2468-2667(22)00227-4
• 发表时间: 2022-12
• 期刊: The Lancet. Public health
• 作者: Chan KH;Wright N;Xiao D;Guo Y;Chen Y;Du H;Yang L;Millwood IY;Pei P;Wang J;Turnbull I;Gilbert S;Avery D;Kartsonaki C;Yu C;Chen J;Lv J;Clarke R;Collins R;Peto R;Li L;Wang C;Chen Z;China Kadoorie Biobank collaborative group
• 通讯作者: China Kadoorie Biobank collaborative group

The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.

• DOI: 10.1016/s0140-6736(11)60739-3
• 发表时间: 2011-06-25
• 期刊: LANCET
• 影响因子: 168.9
• 作者: Baigent, Colin;Landray, Martin J.;Reith, Christina;Emberson, Jonathan;Wheeler, David C.;Tomson, Charles;Wanner, Christoph;Krane, Vera;Cass, Alan;Craig, Jonathan;Neal, Bruce;Jiang, Lixin;Hooi, Lai Seong;Levin, Adeera;Agodoa, Lawrence;Gaziano, Mike;Kasiske, Bertram;Walker, Robert;Massy, Ziad A.;Feldt-Rasmussen, Bo;Krairittichai, Udom;Ophascharoensuk, Vuddidhej;Fellstrom, Bengt;Holdaas, Hallvard;Tesar, Vladimir;Wiecek, Andrzej;Grobbee, Diederick;de Zeeuw, Dick;Gronhagen-Riska, Carola;Dasgupta, Tanaji;Lewis, David;Herrington, William;Mafham, Marion;Majoni, William;Wallendszus, Karl;Grimm, Richard;Pedersen, Terje;Tobert, Jonathan;Armitage, Jane;Baxter, Alex;Bray, Christopher;Chen, Yiping;Chen, Zhengming;Hill, Michael;Knott, Carol;Parish, Sarah;Simpson, David;Sleight, Peter;Young, Alan;Collins, Rory
• 通讯作者: Collins, Rory

New Horizons: the value of UK Biobank to research on endocrine and metabolic disorders.

• DOI: 10.1210/clinem/dgac407
• 发表时间: 2022-08-18
• 期刊: The Journal of clinical endocrinology and metabolism