UK Biobank pilot imaging enhancement

英国生物银行试点成像增强

• 批准号: MC_PC_12027
• 负责人: Rory Collins
• 金额: $ 1223.23万
• 依托单位: Wellcome Trust
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_12027
• 关键词: UK; Biobank; pilot; imaging; enhancement

In UK Biobank, questionnaire data, physical measurements and biological samples have been collected from 500,000 men and women aged 40-69, and their health is now being followed long-term. A prospective cohort like UK Biobank allows reliable assessment of the relevance of many different exposures to the development of many different diseases. However, such studies need to be big because only a relatively small proportion of participants will develop any particular disease. It is now planned to conduct specialised imaging of the brain, heart, large blood vessels, abdomen, bone and joints in 100,000 UK Biobank participants. Although imaging has been done in some other studies, these have involved only small numbers of people (typically less than 5,000) and have focussed on imaging particular parts of the body. By contrast, combination of imaging data from different parts of the body in 100,000 UK Biobank participants with the detailed non-imaging data already collected will provide a unique resource for researchers from around the world to investigate the causes of different diseases. (For example, dementia may be related to imaging measures not only from the brain but also from other parts of the body, as well as to genetic, biochemical or environmental information.)

在英国生物银行，已经从50万名40-69岁的男性和女性中收集了问卷数据、身体测量和生物样本，现在正在长期跟踪他们的健康状况。像英国生物库这样的前瞻性队列可以可靠地评估许多不同暴露与许多不同疾病发展的相关性。然而，这样的研究需要很大，因为只有相对较小比例的参与者会患上某种特定的疾病。现在计划对10万名英国生物银行参与者的大脑，心脏，大血管，腹部，骨骼和关节进行专门的成像。虽然在其他一些研究中也进行了成像，但这些研究只涉及少数人（通常少于5,000人），并且集中在身体的特定部位成像。相比之下，将来自10万名英国生物银行参与者身体不同部位的成像数据与已经收集的详细非成像数据相结合，将为来自世界各地的研究人员提供独特的资源，以调查不同疾病的原因。(For例如，痴呆症可能不仅与大脑的成像测量有关，而且与身体其他部位的成像测量有关，还与遗传、生物化学或环境信息有关。

项目成果

New Horizons: the value of UK Biobank to research on endocrine and metabolic disorders.

• DOI: 10.1210/clinem/dgac407
• 发表时间: 2022-08-18
• 期刊: The Journal of clinical endocrinology and metabolism

Adiposity and NMR-measured lipid and metabolic biomarkers among 30,000 Mexican adults.

• DOI: 10.1038/s43856-022-00208-2
• 发表时间: 2022-11-14
• 期刊: COMMUNICATIONS MEDICINE
• 作者: Aguilar-Ramirez, Diego;Herrington, William G.;Alegre-Diaz, Jesus;Staplin, Natalie;Ramirez-Reyes, Raul;Gnatiuc, Louisa Friedrichs;Hill, Michael;Romer, Frederik;Trichia, Eirini;Bragg, Fiona;Wade, Rachel;Lewington, Sarah;Collins, Rory;Emberson, Jonathan R.;Kuri-Morales, Pablo;Tapia-Conyer, Roberto
• 通讯作者: Tapia-Conyer, Roberto

Genetically Predicted Differences in Systolic Blood Pressure and Risk of Cardiovascular and Noncardiovascular Diseases: A Mendelian Randomization Study in Chinese Adults.

• DOI: 10.1161/hypertensionaha.122.20120
• 发表时间: 2023-03
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Clarke R;Wright N;Walters R;Gan W;Guo Y;Millwood IY;Yang L;Chen Y;Lewington S;Lv J;Yu C;Avery D;Lin K;Wang K;Peto R;Collins R;Li L;Bennett DA;Parish S;Chen Z;China Kadoorie Biobank Collaborative Group‡
• 通讯作者: China Kadoorie Biobank Collaborative Group‡

Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people.

• DOI: 10.1186/s12916-022-02330-3
• 发表时间: 2022-05-06
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Kakkoura, Maria G.;Du, Huaidong;Guo, Yu;Yu, Canqing;Yang, Ling;Pei, Pei;Chen, Yiping;Sansome, Sam;Chan, Wing Ching;Yang, Xiaoming;Fan, Lei;Lv, Jun;Chen, Junshi;Li, Liming;Key, Timothy J.;Chen, Zhengming
• 通讯作者: Chen, Zhengming

UK Biobank: a globally important resource for cancer research.

• DOI: 10.1038/s41416-022-02053-5
• 发表时间: 2023-02
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Conroy, Megan C.;Lacey, Ben;Besevic, Jelena;Omiyale, Wemimo;Feng, Qi;Effingham, Mark;Sellers, Jonathan;Sheard, Simon;Pancholi, Mahesh;Gregory, Gareth;Busby, John;Collins, Rory;Allen, Naomi E.
• 通讯作者: Allen, Naomi E.