Mitochondrial biogenesis and disease

线粒体生物发生和疾病

• 批准号: MC_PC_12029
• 负责人: Rory Collins
• 金额: $ 509.68万
• 依托单位: Wellcome Trust
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_12029
• 关键词: Mitochondrial; biogenesis; disease

UK Biobank has been set up to allow the reliable assessment of the relevance of a wide range of different types of exposure (including lifestyle, environment and genes) to a wide range of different diseases (including those that cause much morbidity and disability but have not previously been extensively investigated). Recruitment into UK Biobank started in 2007 (following a successful pilot in 2006), and enrolment of 500,000 men and women aged 40 to 69 was achieved by mid-2010. Such prospective cohorts typically involve collection of either a large amount of data on a small number of participants (sometimes referred to as “data depth”) or a small amount of data on a large number of participants (referred to as “data breadth”). By contrast, in UK Biobank, extensive questionnaire data, physical measures and biological samples have been collected for a very large number of participants (i.e. both depth and breadth have been achieved). This outcome was enabled by the establishment of highly efficient, purpose-designed centralised processes with detailed input from UK Biobank’s extensive academic collaborative network. Activity is now focused on following the health of the participants and providing easy access to researchers who wish to use this resource (which is open for applications from end March 2012 through the website: www.ukbiobank.ac.uk).In order to enhance further the value of the UK Biobank resource to researchers it is proposed that a wide range of biochemical markers are measured in samples collected at baseline from all 500,000 of the participants. The biomarkers selected for assay have been chosen because they are established risk factors for disease (e.g., lipids for vascular disease, sex hormones for cancer), diagnostic measures (e.g., HbA1c for diabetes and rheumatoid factor for arthritis), markers of exposure (e.g., cotinine for tobacco exposure), or characterize phenotypes not otherwise well assessed (e.g., biomarkers for renal and liver function). UK Biobank’s Enhancements Working Group has been responsible for developing the present proposal following extensive consultation with relevant expert to identify biomarkers that are likely to be of most scientific relevance for studying a wide range of diseases. The availability of this wide range of markers for all of the participants would be a cost-effective way of increasing usability of the resource for many different researchers.

已经建立了英国生物库，以允许对各种不同类型的暴露（包括生活方式，环境和基因）的相关性进行可靠的评估，以对广泛的不同疾病（包括引起多种发病率和残疾的疾病，但并未经过广泛研究）。招募英国生物银行始于2007年（在2006年成功进行了飞行员之后），50万名男女招募40至69岁的男女通常涉及收集大量参与者的大量数据（有时称为“数据深度”）或大量参与者的数据（参与数据的大量参与者）。相比之下，在英国生物库中，已经为大量参与者收集了广泛的问卷数据，物理测量和生物样品（即已实现了深度和广度）。通过建立高效，专门设计的集中流程，并通过英国Biobank广泛的学术协作网络的详细意见来实现这一结果。现在，活动专注于遵循参与者的健康状况，并为希望使用此资源的研究人员提供轻松的访问（该研究人员开放（从2012年3月结束到2012年底通过网站开放：www.ukbiobank.ac.ac.uk）。为了进一步增强英国生物银行资源的价值，以便为研究人员提供了对研究人员的广泛范围，该范围是来自二元组的众多样品，该样品是在基础上进行的，该样品是基于5000的基础。之所以选择选择用于测定的生物标志物，是因为它们是疾病的确定危险因素（例如，血管疾病的脂质，癌症的性恐怖症），诊断措施（例如，糖尿病的HBA1C和关节炎的类风湿因子），暴露的标记（例如，Cotinine for cotinine for cotinine contriped contipe），或表征（e。用于肾功能和肝功能的生物标志物）。在与相关专家进行了广泛的咨询之后，英国生物银行的增强工作组负责制定本提案，以确定可能在研究广泛疾病方面具有最科学意义的生物标志物。所有参与者的广泛标记物的可用性将是提高许多不同研究人员资源可用性的一种经济有效的方式。

项目成果

New Horizons: the value of UK Biobank to research on endocrine and metabolic disorders.

• DOI: 10.1210/clinem/dgac407
• 发表时间: 2022-08-18
• 期刊: The Journal of clinical endocrinology and metabolism

Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study.

• DOI: 10.1016/s2468-2667(22)00227-4
• 发表时间: 2022-12
• 期刊: The Lancet. Public health
• 作者: Chan KH;Wright N;Xiao D;Guo Y;Chen Y;Du H;Yang L;Millwood IY;Pei P;Wang J;Turnbull I;Gilbert S;Avery D;Kartsonaki C;Yu C;Chen J;Lv J;Clarke R;Collins R;Peto R;Li L;Wang C;Chen Z;China Kadoorie Biobank collaborative group
• 通讯作者: China Kadoorie Biobank collaborative group

SARS-CoV-2 is associated with changes in brain structure in UK Biobank.

• DOI: 10.1038/s41586-022-04569-5
• 发表时间: 2022-04
• 期刊: Nature
• 影响因子: 64.8

UK Biobank: a globally important resource for cancer research.

• DOI: 10.1038/s41416-022-02053-5
• 发表时间: 2023-02
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Conroy, Megan C.;Lacey, Ben;Besevic, Jelena;Omiyale, Wemimo;Feng, Qi;Effingham, Mark;Sellers, Jonathan;Sheard, Simon;Pancholi, Mahesh;Gregory, Gareth;Busby, John;Collins, Rory;Allen, Naomi E.
• 通讯作者: Allen, Naomi E.

Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people.

• DOI: 10.1186/s12916-022-02330-3
• 发表时间: 2022-05-06
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Kakkoura, Maria G.;Du, Huaidong;Guo, Yu;Yu, Canqing;Yang, Ling;Pei, Pei;Chen, Yiping;Sansome, Sam;Chan, Wing Ching;Yang, Xiaoming;Fan, Lei;Lv, Jun;Chen, Junshi;Li, Liming;Key, Timothy J.;Chen, Zhengming
• 通讯作者: Chen, Zhengming