Mitochondrial biogenesis and disease

线粒体生物发生和疾病

• 批准号: MC_PC_12029
• 负责人: Rory Collins
• 金额: $ 509.68万
• 依托单位: Wellcome Trust
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_12029
• 关键词: Mitochondrial; biogenesis; disease

UK Biobank has been set up to allow the reliable assessment of the relevance of a wide range of different types of exposure (including lifestyle, environment and genes) to a wide range of different diseases (including those that cause much morbidity and disability but have not previously been extensively investigated). Recruitment into UK Biobank started in 2007 (following a successful pilot in 2006), and enrolment of 500,000 men and women aged 40 to 69 was achieved by mid-2010. Such prospective cohorts typically involve collection of either a large amount of data on a small number of participants (sometimes referred to as “data depth”) or a small amount of data on a large number of participants (referred to as “data breadth”). By contrast, in UK Biobank, extensive questionnaire data, physical measures and biological samples have been collected for a very large number of participants (i.e. both depth and breadth have been achieved). This outcome was enabled by the establishment of highly efficient, purpose-designed centralised processes with detailed input from UK Biobank’s extensive academic collaborative network. Activity is now focused on following the health of the participants and providing easy access to researchers who wish to use this resource (which is open for applications from end March 2012 through the website: www.ukbiobank.ac.uk).In order to enhance further the value of the UK Biobank resource to researchers it is proposed that a wide range of biochemical markers are measured in samples collected at baseline from all 500,000 of the participants. The biomarkers selected for assay have been chosen because they are established risk factors for disease (e.g., lipids for vascular disease, sex hormones for cancer), diagnostic measures (e.g., HbA1c for diabetes and rheumatoid factor for arthritis), markers of exposure (e.g., cotinine for tobacco exposure), or characterize phenotypes not otherwise well assessed (e.g., biomarkers for renal and liver function). UK Biobank’s Enhancements Working Group has been responsible for developing the present proposal following extensive consultation with relevant expert to identify biomarkers that are likely to be of most scientific relevance for studying a wide range of diseases. The availability of this wide range of markers for all of the participants would be a cost-effective way of increasing usability of the resource for many different researchers.

英国生物银行的建立是为了可靠地评估各种不同类型的暴露（包括生活方式、环境和基因）与各种不同疾病（包括那些导致大量发病和残疾但以前未经广泛研究的疾病）的相关性。英国生物银行于 2007 年开始招募（继 2006 年成功试点之后），到 2010 年中期已招募了 500,000 名 40 至 69 岁的男性和女性。此类前瞻性队列通常涉及收集少量参与者的大量数据（有时称为“数据深度”）或收集大量参与者的少量数据（称为“数据广度”）。相比之下，英国生物银行为大量参与者收集了广泛的问卷数据、物理测量和生物样本（即深度和广度都达到了）。这一成果是通过建立高效、专门设计的集中流程以及英国生物银行广泛的学术合作网络的详细输入而实现的。现在的活动重点是关注参与者的健康状况，并为希望使用该资源的研究人员提供方便的访问（该资源从 2012 年 3 月末开始通过网站开放申请：www.ukbiobank.ac.uk）。为了进一步提高英国生物库资源对研究人员的价值，建议对从所有 500,000 名参与者收集的基线样本中进行广泛的生化标记物测量。选择用于测定的生物标志物是因为它们是疾病的既定危险因素（例如，血脂用于血管疾病，性激素用于癌症），诊断措施（例如，HbA1c用于糖尿病，类风湿因子用于关节炎），暴露标志物（例如，可替宁用于烟草暴露），或表征未通过其他方式充分评估的表型（例如， 肾功能和肝功能的生物标志物）。英国生物银行的增强工作组在与相关专家进行广泛协商后负责制定本提案，以确定可能与研究多种疾病最具科学相关性的生物标志物。为所有参与者提供如此广泛的标记将是一种经济高效的方式，可以提高许多不同研究人员的资源可用性。

项目成果

New Horizons: the value of UK Biobank to research on endocrine and metabolic disorders.

• DOI: 10.1210/clinem/dgac407
• 发表时间: 2022-08-18
• 期刊: The Journal of clinical endocrinology and metabolism

SARS-CoV-2 is associated with changes in brain structure in UK Biobank.

• DOI: 10.1038/s41586-022-04569-5
• 发表时间: 2022-04
• 期刊: Nature
• 影响因子: 64.8

Tobacco smoking and risks of more than 470 diseases in China: a prospective cohort study.

• DOI: 10.1016/s2468-2667(22)00227-4
• 发表时间: 2022-12
• 期刊: The Lancet. Public health
• 作者: Chan KH;Wright N;Xiao D;Guo Y;Chen Y;Du H;Yang L;Millwood IY;Pei P;Wang J;Turnbull I;Gilbert S;Avery D;Kartsonaki C;Yu C;Chen J;Lv J;Clarke R;Collins R;Peto R;Li L;Wang C;Chen Z;China Kadoorie Biobank collaborative group
• 通讯作者: China Kadoorie Biobank collaborative group

Dairy consumption and risks of total and site-specific cancers in Chinese adults: an 11-year prospective study of 0.5 million people.

• DOI: 10.1186/s12916-022-02330-3
• 发表时间: 2022-05-06
• 期刊: BMC MEDICINE
• 影响因子: 9.3
• 作者: Kakkoura, Maria G.;Du, Huaidong;Guo, Yu;Yu, Canqing;Yang, Ling;Pei, Pei;Chen, Yiping;Sansome, Sam;Chan, Wing Ching;Yang, Xiaoming;Fan, Lei;Lv, Jun;Chen, Junshi;Li, Liming;Key, Timothy J.;Chen, Zhengming
• 通讯作者: Chen, Zhengming

UK Biobank: a globally important resource for cancer research.

• DOI: 10.1038/s41416-022-02053-5
• 发表时间: 2023-02
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Conroy, Megan C.;Lacey, Ben;Besevic, Jelena;Omiyale, Wemimo;Feng, Qi;Effingham, Mark;Sellers, Jonathan;Sheard, Simon;Pancholi, Mahesh;Gregory, Gareth;Busby, John;Collins, Rory;Allen, Naomi E.
• 通讯作者: Allen, Naomi E.