UKRI Industrial Strategy Challenge Fund UK BioBank Vanguard Project - Whole Genome Sequencing

UKRI 产业战略挑战基金英国生物银行先锋项目 - 全基因组测序

• 批准号: MC_PC_17223
• 负责人: Rory Collins
• 金额: $ 3822.6万
• 依托单位: UK Biobank
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2018
• 资助国家: 英国
• 起止时间: 2018 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_17223
• 关键词: UKRI; Industrial; Strategy; Challenge; Fund

UK Biobank and UKRI are taking advantage of the revolution in genetics analyses that makes large-scale sequencing of the human genome possible at an ever-quickening pace. With the ultimate goal to sequence all 500,000 UK Biobank participants, this investment as part of the Vanguard project will sequence 50,000 participants and help establish the world’s most detailed whole genome database – and further accelerate research into a wide range of diseases that cause disability and premature death in mid to later

英国生物银行和乌克里岛正在利用遗传学分析的革命，这使得人类基因组的大规模测序以不断提高的速度成为可能。以对所有50万英国生物银行参与者进行序列的最终目标，这项投资作为Vanguard项目的一部分将对50,000名参与者进行序列，并帮助建立世界上最详细的整个基因组数据库，并进一步加速研究，以促进广泛的疾病，这些疾病在中后期导致残疾和过早死亡的疾病。

项目成果

Identification of host-pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank.

• DOI: 10.1038/s41467-022-29307-3
• 发表时间: 2022-04-05
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Mentzer AJ;Brenner N;Allen N;Littlejohns TJ;Chong AY;Cortes A;Almond R;Hill M;Sheard S;McVean G;UKB Infection Advisory Board;Collins R;Hill AVS;Waterboer T
• 通讯作者: Waterboer T

Genome-wide characterization of circulating metabolic biomarkers

• DOI: 10.1038/s41586-024-07148-y
• 发表时间: 2024-03-06
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Karjalainen，Minna K.;Karthikeyan，Savita;Kettunen，Johannes
• 通讯作者: Kettunen，Johannes

SARS-CoV-2 is associated with changes in brain structure in UK Biobank.

• DOI: 10.1038/s41586-022-04569-5
• 发表时间: 2022-04
• 期刊: Nature
• 影响因子: 64.8

New Horizons: the value of UK Biobank to research on endocrine and metabolic disorders.

• DOI: 10.1210/clinem/dgac407
• 发表时间: 2022-08-18
• 期刊: The Journal of clinical endocrinology and metabolism

UK Biobank: a globally important resource for cancer research.

• DOI: 10.1038/s41416-022-02053-5
• 发表时间: 2023-02
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Conroy, Megan C.;Lacey, Ben;Besevic, Jelena;Omiyale, Wemimo;Feng, Qi;Effingham, Mark;Sellers, Jonathan;Sheard, Simon;Pancholi, Mahesh;Gregory, Gareth;Busby, John;Collins, Rory;Allen, Naomi E.
• 通讯作者: Allen, Naomi E.