Research Training in Gastroenterology

描述(由申请人提供)： 这是一项竞争的延续申请，要求续签1999年首次资助的胃肠病学培训计划。自那时以来，已有20名学员获得资助，其中除4人外，其余均为全职学术职位，或全职从事工业研究，或仍在接受培训。该计划的目标是为致力于研究胃肠病学或相关领域的年轻研究人员提供两到三年的研究培训。研究培训的类型包括基础研究、转化性研究或临床研究，或这些研究的组合。受训者可能是医学博士、医学博士或博士，他们已完成临床或研究生培训，并正在寻求进一步的胃肠病学研究培训。培训将主要包括有指导的研究，这些研究将提供密集的实践经验。还将提供丰富的教学课程、研讨会、研讨会和会议菜单。以患者为中心的研究实习生将被要求完成课程作业和论文要求，以获得MMS、公共卫生硕士或同等学位。所有受训者将在第三年的研究培训期间提交K系列NIH奖项的拨款申请或研究基金会的支持。受训者将由经验丰富的研究导师指导，这些导师具有从基础细胞和分子生物学到临床研究的广泛兴趣和专业知识。由凯利博士、罗布森博士、特霍斯特博士和兰特博士以及一两名其他培训人员组成的培训委员会将监督整个研究培训计划，选择合适的候选人并监督进展。学员研究计划将在四个广泛的领域提供，这些领域与该司的临床卓越中心相结合：1)肠道感染与免疫肝损伤和纤维化3.)维管生物学和4.)上皮生物学。该培训计划将利用GL分部、内科和外科以及哈佛医学院和公共卫生学院内优秀的GL研究基地。培训计划还将受益于BIDMC组织良好、资金充足的综合临床研究中心，以及两个消化系统疾病中心，一个在哈佛医学院，另一个在马萨诸塞州综合医院。后勤司在招聘女性和少数族裔受训人员和教员方面有着良好的记录，并为今后少数群体的外联和征聘制定了积极的计划。 公共卫生相关性：该计划将解决一般医学特别是胃肠病学中的一个关键问题：训练有素的内科科学家和专注于Gl和肝脏疾病的基础研究人员的供应日益减少。该计划将把BASE研究与临床问题和问题结合起来，更好地解决我们专业在诊断和治疗方面的信息差距。我们的最终目标是培养出能够成功竞争初创研究资金和初级教师职位，并继续对基础或临床研究表现出重大承诺的个人。

DESCRIPTION (provided by applicant): This is a competing continuation application for renewal of a training program in gastroenterology that was first funded in 1999. Since then, 20 trainees have been supported, of whom all but four are in full time academic positions, or full-time research in industry, or still in training. The goal of this program is to provide two or three years of research training for young researchers committed to a career in investigative gastroenterology or allied fields. The types of research training include basic, translational or clinical research, or combinations of these. Trainees may be MDs, MD-PhDs or PhDs who have finished clinical or graduate training and are seeking further research training in gastroenterology. Training will consist primarily of mentored research that will provide intense hands-on experience. An extensive menu of didactic courses, workshops, seminars and conferences will also be provided. Trainees in patient-oriented research will be expected to complete course work and thesis requirements to obtain an MMS, MPH or equivalent degree. All trainees will be expected to submit grant applications for K-series NIH awards or support from research foundations during the 3rd year of research training. Trainees will be supervised by experienced research mentors with a wide range of interests and expertise from basic cellular and molecular biology to clinical research. A training committee composed of Drs. Kelly, Robson, Terhorst and Lament and one or two other training faculty will monitor the overall research training program, select suitable candidates and monitor progress. Trainee research programs will be available in four broad areas that are integrated with clinical centers of excellence in the Division: 1.) Intestinal Infection and Immunity 2.) Liver Injury and Fibrosis 3.) Vascular Biology and 4.) Epithelial Biology. The training program will take advantage of the outstanding Gl research base within the Gl Division, the Departments of Medicine and Surgery and at Harvard Medical School and School of Public Health. The training program will also benefit from the availability of a well organized and funded General Clinical Research Center at BIDMC, as well as the close proximity of two Digestive Disease Centers, one at Harvard Medical School and a second at Massachusetts General Hospital. The Gl Division has a good track record of recruitment of female and minority trainees and faculty, and has an active plan for future minority outreach and recruitment. PUBLIC HEALTH RELEVANCE: This program will address a critical issue in medicine in general and gastroenterology in particular: the dwindling supply of well-trained physician-scientists and basic researchers focused on Gl and liver diseases. The program will integrate bench research with clinical questions and problems to better address the information gaps in diagnosis and treatment in our specialty. Our ultimate goal is to produce individuals who are able to compete successfully for start-up research funding and for entry level faculty positions and who continue to exhibit a substantial commitment to basic or clinical research.