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Merging Diffuse Optical Tomography with EEG, MEG and MRI for Neurovascular Exams

将漫射光学断层扫描与 EEG、MEG 和 MRI 相结合进行神经血管检查

基本信息

批准号：
7904126
负责人：
Solomon Gilbert Diamond
金额：
$ 12.69万
依托单位：
DARTMOUTH COLLEGE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7904126
关键词：
Address Age Area Biological Markers Blood Blood Vessels Brain Cerebrovascular Circulation Cerebrum Clinical Coupling Diagnosis Electrodes Electroencephalography Engineering Evaluation Extravasation Fiber Functional Magnetic Resonance Imaging Future Hair Head Height Human Human Volunteers Image Light Magnetic Resonance Imaging Magnetoencephalography Manuals Measurement Measures Mechanics Modality Modeling Monitor Morphologic artifacts Motion Multimodal Imaging Near-Infrared Spectroscopy Neurologic Noise Optics Patient Monitoring Performance Photons Physiology Positioning Attribute Prevalence Procedures Research Resolution Route Running Scalp structure Scientist Secure Shapes Signal Transduction Staging Surface Technology Testing Time United States Variant Weight Work aging brain base design diffuse optical tomography electrical potential hemodynamics imaging modality improved magnetic field meetings nervous system disorder neuroimaging new technology optical fiber performance tests prevent public health relevance relating to nervous system sensor tool

项目摘要

DESCRIPTION (provided by applicant): The objective of this research is to advance the technology used for noninvasive, simultaneous measurement of signals related to neural currents and hemodynamics in the human brain. Diffuse optical tomography (DOT) is an imaging extension of near-infrared spectroscopy (NIRS) that is used to measure cerebral blood oxygenation changes with high temporal resolution. DOT is compatible with electroencephalography (EEG) and magnetoencephalography (MEG), which respectively measure electrical potential and magnetic fields from neural currents. Combining DOT with EEG and MEG provides a window into the temporal relationship between neural and vascular dynamics in the brain. Improved spatial localization for neurovascular studies can be achieved by combining DOT and EEG with functional magnetic resonance imaging (fMRI). Studies of the neurovascular relationship will bring scientific breakthroughs in our understanding of human brain physiology and in the diagnosis and monitoring of patients with neurological diseases. These studies, however, require newly engineered probes for simultaneous measurement from the human head with multiple measurement modalities. The thrust of this work is to redesign the DOT probes to achieve geometric conformity and materials compatibility with EEG, MEG and MRI. This research has two aims. First is to address the design and fabrication of a multimodal DOT probe. The key specifications are to optimize the tomographic resolution and spectroscopic accuracy with a new probe while maintaining compatibility with EEG, MEG and MRI. The second aim is to test the performance of the new probe. The test procedure will include measuring contact forces under each sensor on a variety of head shapes and quantifying the motion artifacts induced by moving a physical head model with a linear stage. Evaluations will also be run on healthy human volunteers for the set- up time, subject comfort and signal-to-noise ratio under separate and multimodal conditions. Local research and clinical scientists involved in neuroimaging will be invited to offer critical review of the probes. Future applications of a multimodal DOT probe include improving diagnosis and treatment monitoring based on a neurovascular biomarker made possible by this research. New technologies for neurological assessment are vital as the prevalence of age-associated neurological disease increases in the United States. PUBLIC HEALTH RELEVANCE: This research will produce a new noninvasive probe for concurrent measurement of neural and vascular signals related to human brain function. This new tool is needed to support neuroimaging research that aims to advance our understanding of the relationship between neural activity and cerebral blood flow changes. Research on the neurovascular relationship will ultimately have long-term benefits to understanding the aging brain and diagnosing neurological diseases.

描述(申请人提供)：这项研究的目标是推进用于无创、同时测量与人脑神经电流和血流动力学相关的信号的技术。漫反射光学断层成像(DOT)是近红外光谱(NIRS)的成像扩展，用于测量高时间分辨率的脑血氧变化。DOT与脑电图仪(EEG)和脑磁图仪(MEG)兼容，这两种仪器分别测量神经电流的电位和磁场。将DOT与EEG和MEG相结合，为了解大脑中神经和血管动力学之间的时间关系提供了一个窗口。将DOT和EEG与功能磁共振成像(FMRI)相结合，可以改善神经血管研究的空间定位。对神经血管关系的研究将在我们对人脑生理学的理解以及对神经系统疾病患者的诊断和监测方面带来科学突破。然而，这些研究需要新设计的探头来同时从人头进行多种测量方式的测量。这项工作的主旨是重新设计DOT探头，以实现与EEG、MEG和MRI的几何一致性和材料兼容性。本研究有两个目的。首先介绍了多模DOT探头的设计和制造。关键的规格是使用新的探头优化断层扫描分辨率和光谱精度，同时保持与EEG、MEG和MRI的兼容性。第二个目标是测试新探测器的性能。测试程序将包括测量每个传感器在各种头部形状上的接触力，并量化用线性工作台移动物理头部模型所产生的运动伪影。还将对健康的人类志愿者进行单独和多模式条件下的设置时间、受试者舒适度和信噪比的评估。参与神经成像的当地研究和临床科学家将被邀请对这些探针进行批判性审查。多模式DOT探头的未来应用包括改进基于神经血管生物标记物的诊断和治疗监测，该研究使之成为可能。随着与年龄相关的神经疾病在美国的流行程度增加，神经评估的新技术至关重要。公共卫生相关性：这项研究将生产一种新的非侵入性探头，用于同时测量与人类大脑功能相关的神经和血管信号。这一新的工具需要支持神经成像研究，旨在促进我们对神经活动和脑血流变化之间关系的理解。对神经血管关系的研究最终将对了解大脑老化和诊断神经疾病具有长远的好处。