Chemistry-Biology Interface Training Grant

描述（由申请人提供）：本博士前培训项目在化学-生物学界面进行，涉及来自明尼苏达大学化学系、药物化学系、生物化学系、分子生物学和生物物理学（BMBB）三个系的29名培训教师。它旨在为跨越化学和生物学传统学科界限的学员提供研究培训经验。常见的研究主题包括：生物催化剂和双分子设计（Distefano, Kauzlauskus, Lipscomb, Ohlendorf, Schmidt-Dannert, Wackett, Wagner, Wilmot, York），治疗剂（Amin, Bernlohr, Distefano, Georg, Hoye, Mansky, Sturla, Tretyakova, Wagner, Xing），疾病化学（Arriaga, Bernlohr, Mansky, Murphy, Sturla, Tretyakova, Wagner, Walters, Xing），金属生物化学（Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Tolman, Wackett, Wilmot, York），生物分析/生物物理学(Arriaga, Bowser, Griffin，Haynes, Pierre, Taton, Tretyakova, Thomas, Veglia, Walters)。培训学院的研究小组都得到了很好的支持和装备。这里有广泛的多肽和寡核苷酸合成、生物发酵、质谱、x射线晶体学、核磁共振和计算设备。该方案每年要求支助8名受训人员，每名受训人员的支助期为两年。未来的受训人员一般都有化学、生物化学或生物学的本科学位。他们将被期望获得彻底的基础化学，以及分子生物学和生物化学。该培训计划的重点是研究解决生物系统中合成/机械问题的问题，目标是在分子水平上理解和影响关键。这个培训项目的主要特点是让一流的学生在他们感兴趣的主要领域和互补领域成长为有成就的专业人士。学生将从化学和生物的必修课程菜单中进行选择。此外，实验室轮转、化学生物学研讨会、年度专题讨论会、期刊俱乐部和联合小组会议将丰富受训者的毕业经历。相关性：CBITG培训师及其学员共同开展与当前公共卫生重要问题相关的基本问题的研究。这些包括了解癌症是如何在细胞中开始的，肥胖和糖尿病是如何发展的，肌肉是如何工作的，设计和开发针对癌症、艾滋病和阿尔茨海默病的新药和检测探针，以及了解化学物质是如何在环境中分解的。

DESCRIPTION (provided by applicant): This pre-doctoral training program at the Chemistry-Biology Interface involves 29 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). It seeks to provide a research training experience to its trainees that cross the traditional disciplinary boundaries of Chemistry and Biology. Common research themes include: Biocatalysts and Bimolecular Design (Distefano, Kauzlauskus, Lipscomb, Ohlendorf, Schmidt-Dannert, Wackett, Wagner, Wilmot, York), Therapeutic Agents (Amin, Bernlohr, Distefano, Georg, Hoye, Mansky, Sturla, Tretyakova, Wagner, Xing), Chemistry of Disease (Arriaga, Bernlohr, Mansky, Murphy, Sturla, Tretyakova, Wagner, Walters, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Tolman, Wackett, Wilmot, York), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Taton, Tretyakova, Thomas, Veglia, Walters). The research groups of the training faculty are all well supported and well equipped. There are extensive facilities for peptide and oligonucleotide synthesis, biofermentation, mass spectrometry, X-ray crystallography, NMR, and computation. Support is requested for 8 trainees each year of the program, each to be supported for a two-year period. Prospective trainees will generally have undergraduate degrees in chemistry, biochemistry or oiology. They will be expected to obtain thorough grounding in chemistry, as well as molecular biology and biochemistry. The particular emphasis of this training program is a focus on research problems that address synthetic/mechanistic questions in biological systems, with the goal of understanding and influencing key at the molecular level. The defining characteristic for this training program will be to allow first-rate students to grow into accomplished professionals both in their primary area of interest and in a complementary field. Students will choose from a menu of required coursework in chemistry and biology. In addition, laboratory rotations, a chemical biology colloquium, an annual symposium, journal clubs, and joint group meetings will enrich the graduate experience of the trainees. RELEVANCE: The CBITG trainers and their trainees collectively carry out research on fundamental questions related to current important problems in public health. These include understanding how cancers are initiated in the cell, how obesity and diabetes develop and how a muscle works, designing and developing new drugs and assay probes against cancer, HIV, and Alzheimer's disease, and understanding how chemicals are broken down in the environment.