Chemistry-Biology Interface Training Grant

请参阅说明)： 这项化学-生物学接口的博士前培训计划涉及29名培训教师 来自明尼苏达大学的三个系：化学、药物化学和 生物化学、分子生物学和生物物理学(BMBB)。它寻求提供一种研究培训 为学员提供跨越化学和化学传统学科界限的体验 生物学。共同的研究主题包括：生物催化和生物分子设计(Distefano， Kauzlauskus，Lipscomb，Ohlendorf，Schmidt-Dannert，Wackett，Wagner，Wilmot，York)，治疗 经纪人(Amin，Bernlohr，Distefano，Georg，Hoye，Mansky，Sturla，Tretyakova，Wagner，Xing)， 疾病化学(Arriaga，Bernlohr，Mansky，Murphy，Sturla，Tretyakova，Wagner，Walters， Xing)，代谢生物化学(Amin，Lipscomb，Murphy，Ohlendorf，Pierre，Que，Tolman，Wackett， 和生物分析/生物物理学(Arriaga，Bowser，Griffin，Haynes，Pierre，Taton， Tretyakova，Thomas，Veglia，Walters)。培训部的课题组都很好 有保障，装备精良。有广泛的多肽和寡核苷酸合成设施， 生物发酵、质谱学、X射线结晶学、核磁共振和计算。 该计划每年为8名受训人员提供支持，每人提供为期两年的支持 句号。未来的受训者一般拥有化学、生物化学或 油学。他们将有望在化学和分子方面获得彻底的基础。 生物学和生物化学。这一培训计划的重点是研究 解决生物系统中的合成/机械问题的问题，目标是 在分子水平上理解和影响关键。此培训的定义特征是 该计划将允许一流的学生成长为有成就的专业人士，在他们的 主要感兴趣的领域和补充领域。学生将从所需的菜单中进行选择 化学和生物的课程作业。此外，还有实验室轮换、化学生物学座谈会、 年度研讨会、期刊俱乐部和联合小组会议将丰富研究生的经验 实习生。 相关性(请参阅说明)： CBITG培训员及其受训人员集体开展与以下方面有关的基本问题研究 当前公共卫生面临的重要问题。这些包括了解癌症是如何在 细胞，肥胖和糖尿病是如何发展的，肌肉是如何工作的，设计和开发新药和 癌症、艾滋病毒和阿尔茨海默氏症的检测探针，以及了解化学物质是如何被破坏的 在环境中。

See instructions): This pre-doctoral training program at the Chemistry-Biology Interface involves 29 training faculty from three departments at the University of Minnesota: Chemistry, Medicinal Chemistry, and Biochemistry, Molecular Biology and Biophysics (BMBB). It seeks to provide a research training experience to its trainees that crosses the traditional disciplinary boundaries of Chemistry and Biology. Common research themes include: Biocatalysis and Biomolecular Design (Distefano, Kauzlauskus, Lipscomb, Ohlendorf, Schmidt-Dannert, Wackett, Wagner, Wilmot, York), Therapeutic Agents (Amin, Bernlohr, Distefano, Georg, Hoye, Mansky, Sturla, Tretyakova, Wagner, Xing), Chemistry of Disease (Arriaga, Bernlohr, Mansky, Murphy, Sturla, Tretyakova, Wagner, Walters, Xing), Metallobiochemistry (Amin, Lipscomb, Murphy, Ohlendorf, Pierre, Que, Tolman, Wackett, Wilmot, York), and Bioanalytical/Biophysical (Arriaga, Bowser, Griffin, Haynes, Pierre, Taton, Tretyakova, Thomas, Veglia, Walters). The research groups of the training faculty are all well supported and well equipped. There are extensive facilities for peptide and oligonucleotide synthesis, biofermentation, mass spectrometry, X-ray crystallography, NMR, and computation. Support is requested for 8 trainees each year of the program, each to be supported for a two-year period. Prospective trainees will generally have undergraduate degrees in chemistry, biochemistry or oiology. They will be expected to obtain thorough grounding in chemistry, as well as molecular biology and biochemistry. The particular emphasis of this training program is a focus on research problems that address synthetic/mechanistic questions in biological systems, with the goal of understanding and influencing key at the molecular level. The defining characteristic for this training program will be to allow first-rate students to grow into accomplished professionals both in their primary area of interest and in a complementary field. Students will choose from a menu of required coursework in chemistry and biology. In addition, laboratory rotations, a chemical biology colloquium, an annual symposium, journal clubs, and joint group meetings will enrich the graduate experience of the trainees. RELEVANCE (Seeinstructions): The CBITG trainers and their trainees collectively carry out research on fundamental questions related to current important problems in public health. These include understanding how cancers are initiated in the cell, how obesity and diabetes develop and how a muscle works, designing and developing new drugs and assay probes against cancer, HIV, and Alzheimer's disease, and understanding how chemicals are broken down in the environment.