HEALTHY FAT (DAG)

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项建议是关于寻找完美的脂肪，即一种不含反式脂肪但饱和脂肪酸含量较低的脂肪。PI建议，手掌DAG可能是一个很好的选择。假说是，与母体脂肪相比，修饰脂肪(棕榈油DAG或棕榈仁DAG)将导致更高的高密度脂蛋白-C、更低的低密度脂蛋白-C和更低的低密度脂蛋白/高密度脂蛋白-C比率，以及潜在的更低的甘油三酯水平。每天15克棕榈油或棕榈仁DAG脂肪的饮食将与母体、未经修饰的棕榈油或棕榈仁脂肪进行对比测试。 这项研究将是一项随机、两期、盲法交叉设计。在整个喂养期将使用对照背景饮食。参与者将包括健康的男性和女性，年龄30-60岁，低密度脂蛋白-C(120-175 mg/dL)中度升高，高密度脂蛋白-C 30-50 mg/dL，甘油三酯120-350 mg/dL。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is about the search for the perfect fat, i.e. one that is trans fat-free but low is in saturated fatty acids. The PI proposes that a palm DAG may be an excellent choice. The hypothesis is that the modified fat (either palm DAG or palm kernel DAG), compared to the parent fat will result in a higher HDL-C, lower LDL-C, and lower LDL-C/HDL-C ratio, as well as potentially lower TG levels. A diet of 15 g/day of the palm or palm kernel DAG fat will be tested against the parent, unmodified palm or palm kernel fat. The study will be a randomized, 2-period, blinded cross-over design. A control background diet will be used throughout the feeding periods. Participants will include healthy men and women, 30-60 years of age, with moderately elevated LDL-C (120-175 mg/dL) and with HDL-C of 30-50 mg/dL and triglycerides of 120-350 mg/dL.