HEALTHY FAT (DAG)

健康脂肪 (DAG)

• 批准号: 7951349
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 0.18万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951349
• 关键词: Age-Years; Blinded; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; Diet; Fatty acid glycerol esters; Funding; Grant; Institution; Parents; Participant; Randomized; Research; Research Personnel; Resources; Saturated Fatty Acids; Source; Testing; Trans Fats; Triglycerides; United States National Institutes of Health; Woman; feeding; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This proposal is about the search for the perfect fat, i.e. one that is trans fat-free but low is in saturated fatty acids. The PI proposes that a palm DAG may be an excellent choice. The hypothesis is that the modified fat (either palm DAG or palm kernel DAG), compared to the parent fat will result in a higher HDL-C, lower LDL-C, and lower LDL-C/HDL-C ratio, as well as potentially lower TG levels. A diet of 15 g/day of the palm or palm kernel DAG fat will be tested against the parent, unmodified palm or palm kernel fat. The study will be a randomized, 2-period, blinded cross-over design. A control background diet will be used throughout the feeding periods. Participants will include healthy men and women, 30-60 years of age, with moderately elevated LDL-C (120-175 mg/dL) and with HDL-C of 30-50 mg/dL and triglycerides of 120-350 mg/dL.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这个建议是关于寻找完美的脂肪，即不含反式脂肪但饱和脂肪酸含量低的脂肪。 PI提出，手掌DAG可能是一个很好的选择。 假设是，与母体脂肪相比，改性脂肪（棕榈DAG或棕榈仁DAG）将导致更高的HDL-C、更低的LDL-C和更低的LDL-C/HDL-C比率，以及潜在的更低的TG水平。将对照母体、未改性棕榈或棕榈仁脂肪测试15 g/天棕榈或棕榈仁DAG脂肪的饮食。 本研究为随机、2阶段、设盲交叉设计。在整个饲喂期间将使用对照背景饲料。参与者将包括健康男性和女性，年龄30-60岁，LDL-C中度升高（120-175 mg/dL），HDL-C为30-50 mg/dL，甘油三酯为120-350 mg/dL。