WEIGHT LOSS & CVD PREVENTION VIA WHOLE GRAIN DIET IN PEOPLE W METABOLIC SYNDROME

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• 批准号: 7625826
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 10.64万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625826
• 关键词: Blood Pressure; Body Composition; Body Weight decreased; C-reactive protein; Central obesity; Computer Retrieval of Information on Scientific Projects Database; Daily; Data; Diet; Diet Records; Dietary Fiber; Dietitian; Dyslipidemias; Eating; Event; Funding; Glucose; Glucose Intolerance; Grant; Hypertension; Individual; Institution; Insulin; Intake; Measurement; Measures; Metabolic; Metabolic syndrome; Modeling; Nutritional; OGTT; Outcome; Plasminogen Activator Inhibitor 1; Prevalence; Prevention; Randomized; Research; Research Personnel; Resources; Risk; Risk Factors; Sampling; Source; Study Subject; Testing; United States National Institutes of Health; Visit; Week; Weight; base; day; diaries; dietary restriction; interest; reproductive function; response; waist circumference

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Metabolic syndrome is classified on the basis of a constellation of CVD risk factors, including hypertension, glucose intolerance, abdominal obesity and dyslipidemia, which dramatically increase CVD risk. The prevalence of metabolic syndrome is significantly lower among individuals who consume the most whole grains, however no studies have employed whole grains as a potential treatment for metabolic syndrome. Subjects will be randomized to one of two energy-restricted diets for 3-months: intake of either six servings of whole grains per day or zero servings of whole grains per day. Subjects will be instructed, and required, to keep track of their daily food intake including their whole grain intake in a diet diary. Every other week, subjects will visit the GCRC and review their diet with the dietitian who will also discuss a nutritional topic of interest . At each visit we will record the subjects' weight, blood pressure, waist circumference and body composition. At baseline and at the end of the study we will measure metabolic syndrome criteria as well as weight, body composition, C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1), glucose and insulin response to an oral glucose tolerance test, and other measures of metabolic and reproductive function. At nine months following completion of the study, subjects will complete a 3-day diet record and go to the GCRC for measurement of their weight. For the primary outcome of difference in weight loss between the two diets, the two-sample t-test will be used. In the event that the distribution of weight loss is not normal, the nonparametric Wilcoxon-Mann-Whitney test will be used. For all continuous primary and the secondary outcomes, a linear mixed-effects model will be fit to the data to assess within-diet as well as between-diet differences.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 代谢综合征是根据一系列CVD风险因素进行分类的，包括高血压、葡萄糖耐受不良、腹部肥胖和血脂异常，这些因素会显著增加CVD风险。 代谢综合征的患病率在食用全谷物最多的人中显着降低，但没有研究将全谷物作为代谢综合征的潜在治疗方法。 受试者将被随机分配到两种能量限制饮食中的一种，持续3个月：每天摄入6份全谷物或每天摄入0份全谷物。 将指导并要求受试者在饮食日记中记录其每日食物摄入量，包括全谷物摄入量。 每隔一周，受试者将访问GCRC，并与营养师一起审查他们的饮食，营养师还将讨论感兴趣的营养主题。 每次访视时，我们将记录受试者的体重、血压、腰围和身体成分。 在基线和研究结束时，我们将测量代谢综合征标准以及体重、身体组成、C反应蛋白（CRP）、纤溶酶原激活物抑制剂-1（派-1）、葡萄糖和胰岛素对口服葡萄糖耐量试验的反应，以及其他代谢和生殖功能指标。 在研究完成后9个月，受试者将完成3天饮食记录，并前往GCRC测量其体重。 对于两种饮食之间体重减轻差异的主要结局，将使用双样本t检验。 如果体重减轻的分布不呈正态分布，则将使用非参数Wilcoxon-Mann-Whitney检验。 对于所有连续的主要和次要结局，将对数据拟合线性混合效应模型，以评估饮食内和饮食间差异。