BOLD (BEEF IN AN OPTIMAL LEAN DIET) EFFECTS ON METABOLIC SYNDROME BOLD-X

BOLD（最佳瘦肉饮食中的牛肉）对代谢综合征的影响 BOLD-X

• 批准号: 7951347
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 3.65万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951347
• 关键词: Blood Pressure; Body Weight decreased; Calories; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diet; Dietitian; Energy Intake; Funding; Goals; Grant; Human; Individual; Institution; Kinesiology; Metabolic syndrome; Modification; Monitor; Nutrient; Pamphlets; Participant; Phase; Phase I Clinical Trials; Phase II Clinical Trials; Physical activity; Proteins; Recommendation; Research; Research Personnel; Resources; Risk Factors; Source; Training; Triglycerides; United States National Institutes of Health; Upper arm; beef; design; energy balance; feeding; fruits and vegetables; meetings

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Phase I) of this study was a four-week controlled, three parallel arm feeding trial of individuals with metabolic syndrome to compare the effects of three diets designed to meet nutrient recommendations with the following modifications: (1) lean beef 5 oz/day (overall diet is 18% energy from protein) (2) lean beef 7 oz/day (28% energy from protein or "high protein"); and (3) a modified version of the Dietary Approaches to Stop Hypertention (DASH) diet (high in fruits/vegetables and dairy with nutrient profile compositionally similar to #1. In this phase II of the study the participants continue on their respective diets but with decreased energy intake and increased physical activity designed to achieve weight loss of 1-2 pounds/week over six weeks (approximately 500-1000 calories/day in negative energy balance). Physical activity will be gradually increased beginning in the last two weeks of Phase I. Subjects will be provided with a pedometer to monitor daily step counts with a goal of achieving 8,000-10,000 steps/day on 5 or more days of the week by the end of phase II. This level of activity would be consistent with a "a somewhat active to active" level. During phase II subjects will receive physical activity and dietary guidance via pamphlets and face-to-fact sessions with a professional trained in human movement science and a registered dietitian. The investigators hypothesize that weight loss will be similar across diets but the highest protein diet will leaded to increased improvements in CV risk factors such as blood pressure and triglycerides when compared to the other two diets.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的第一阶段是一项为期四周的对照试验，对代谢综合征患者进行三组平行喂养试验，以比较三种饮食的效果，这些饮食旨在满足营养推荐，并进行以下修改：（1）瘦牛肉5盎司/天（整体饮食是18%的能量来自蛋白质）（2）瘦牛肉7盎司/天（28%的能量来自蛋白质或“高蛋白”）;和（3）停止高血压的饮食方法（DASH）饮食的修改版本（富含水果/蔬菜和乳制品，营养成分与#1相似。 在该研究的第二阶段，参与者继续各自的饮食，但减少能量摄入和增加体力活动，旨在在六周内实现1-2磅/周的体重减轻（负能量平衡约500-1000卡路里/天）。 从第一阶段的最后两周开始，体力活动将逐渐增加。 将为受试者提供计步器，以监测每日步数，目标是在II期结束时每周5天或更多天达到8，000 - 10，000步/天。 这一活动水平将与“有点活跃到活跃”的水平相一致。 在第二阶段，受试者将通过小册子和面对面的会议接受身体活动和饮食指导，会议由受过人体运动科学培训的专业人士和注册营养师主持。 研究人员假设，不同饮食的减肥效果相似，但与其他两种饮食相比，蛋白质含量最高的饮食将导致心血管风险因素（如血压和甘油三酯）的改善。