BOLD (BEEF IN AN OPTIMAL LEAN DIET) EFFECTS ON METABOLIC SYNDROME BOLD-X

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的第一阶段是一项为期四周的三项平行手臂喂养试验，对代谢综合征患者进行为期四周的对照试验，以比较三种饮食的效果，这些饮食旨在满足营养建议，并进行以下修改：(1)每天5盎司瘦牛肉(总饮食中18%的能量来自蛋白质)(2)每天7盎司瘦牛肉(28%能量来自蛋白质或“高蛋白”)；以及(3)一种改良版的“停止高血压饮食方法”(DASH)(高热量摄入水果/蔬菜和乳制品，营养成分与#1相似)。 在这项研究的第二阶段，参与者继续各自的饮食，但能量摄入减少，体力活动增加，旨在实现在六周内每周减重1-2磅(负能量平衡下约500-1000卡路里/天)。从第一阶段的最后两周开始，将逐步增加体力活动。受试者将配备计步器来监测每天的步数，目标是在第二阶段结束时，一周中有5天或更多天每天走8,000-10,000步。这一活动水平将与“某种程度上从活跃到活跃”的水平一致。在第二阶段，受试者将通过小册子和接受过人体运动科学培训的专业人员和注册营养师进行面对面的会议，接受体力活动和饮食指导。研究人员假设，不同饮食的减肥效果相似，但与其他两种饮食相比，高蛋白饮食会导致心血管风险因素(如血压和甘油三酯)的改善。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Phase I) of this study was a four-week controlled, three parallel arm feeding trial of individuals with metabolic syndrome to compare the effects of three diets designed to meet nutrient recommendations with the following modifications: (1) lean beef 5 oz/day (overall diet is 18% energy from protein) (2) lean beef 7 oz/day (28% energy from protein or "high protein"); and (3) a modified version of the Dietary Approaches to Stop Hypertention (DASH) diet (high in fruits/vegetables and dairy with nutrient profile compositionally similar to #1. In this phase II of the study the participants continue on their respective diets but with decreased energy intake and increased physical activity designed to achieve weight loss of 1-2 pounds/week over six weeks (approximately 500-1000 calories/day in negative energy balance). Physical activity will be gradually increased beginning in the last two weeks of Phase I. Subjects will be provided with a pedometer to monitor daily step counts with a goal of achieving 8,000-10,000 steps/day on 5 or more days of the week by the end of phase II. This level of activity would be consistent with a "a somewhat active to active" level. During phase II subjects will receive physical activity and dietary guidance via pamphlets and face-to-fact sessions with a professional trained in human movement science and a registered dietitian. The investigators hypothesize that weight loss will be similar across diets but the highest protein diet will leaded to increased improvements in CV risk factors such as blood pressure and triglycerides when compared to the other two diets.