THE EFFECTS OF PROCESSED TOMATOES ON ENDOTHELIUM AND PLATELET FUNCTION

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目标是：(1)比较连续6周高和低加工番茄摄入量对内皮和血小板功能生物标志物的影响；(2)确定已知的高脂餐对人类诱导血小板聚集和降低血管反应性的影响是否受加工番茄摄入量的影响，或者是否需要同时食用加工番茄来减轻标准高脂餐的影响；(3)调查加工番茄高摄入量和低摄入量对人体血脂成分、氧化应激、血压和炎症状态的影响；(4)确定加工番茄中的抗氧化剂是否会提高人对氧磷酶的活性和浓度。 研究人员假设：(1)与不食用或相对较少食用加工番茄相比，经常/每天食用加工番茄将有利于改善成年男性和女性的血管内皮和血小板功能疾病风险生物标记物的分布；(2)与不/低背景摄入量相比，频繁/每天食用加工番茄以产生稳定的背景加工番茄摄入量，将需要减弱标准高脂餐的血管收缩和血小板聚集效应。食用低加工番茄的背景饮食需要同时食用一份加工番茄，以减轻膳食的血管收缩和血小板聚集作用；(3)经常/每天食用加工番茄会改善血压、血脂、氧化应激和炎症状态。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this study are: (1) to compare the effect of high vs. low intake of processed tomatoes for 6 weeks on biomarkers of endothelium and platelet function; (2) to determine if the effects of a high fat meal known to induce platelet aggregation and reduce vaso-reactivity in humans are influenced by the background intake of processed tomato consumption or if concurrent processed tomato consumption is necessary to attenuate the described affects of the standard high fat meal; (3) to investigate the effects of high vs low consumption of processed tomatoes on plasma lipid composition, oxidative stress, blood pressure and inflammatory status in humans; (4) to determine if the antioxidants in the processed tomatoes will increase the human paraoxonase activity and concentration. The investigators hypothesize that: (1) consuming processed tomatoes frequently/daily will favorably improve endothelium and platelet function disease-risk biomarker profiles in adult men and women compared to consuming no or relatively low amounts of processed tomatoes; (2) consuming processed tomatoes frequently/daily to produce a stable background intake of processed tomatoes compared to no/ low background intake of processed tomatoes will be required to attenuate vaso-constrictive and platelet aggregatory effects of a standard high fat meal. Consuming a background diet low in processed tomatoes will require a single serving of processed tomatoes to be eaten concurrently to attenuate the vaso-constrictive and platelet aggregatory effects of the meal; (3) consuming processed tomatoes frequently/daily will improve blood pressure, the plasma lipid profile, oxidative stress and inflammatory status.