THE EFFECTS OF PROCESSED TOMATOES ON ENDOTHELIUM AND PLATELET FUNCTION

加工番茄对内皮和血小板功能的影响

• 批准号: 7951332
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 3.24万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951332
• 关键词: Adult; Affect; Antioxidants; Attenuated; Biological Markers; Blood Platelets; Blood Pressure; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Consumption; Diet; Eating; Endothelium; Fatty acid glycerol esters; Funding; Goals; Grant; Human; Inflammatory; Institution; Intake; Lipids; Oxidative Stress; Plasma; Platelet aggregation; Process; Research; Research Personnel; Resources; Source; Tomatoes; United States National Institutes of Health; Woman; aryldialkylphosphatase; disorder risk; high standard; improved; men

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goals of this study are: (1) to compare the effect of high vs. low intake of processed tomatoes for 6 weeks on biomarkers of endothelium and platelet function; (2) to determine if the effects of a high fat meal known to induce platelet aggregation and reduce vaso-reactivity in humans are influenced by the background intake of processed tomato consumption or if concurrent processed tomato consumption is necessary to attenuate the described affects of the standard high fat meal; (3) to investigate the effects of high vs low consumption of processed tomatoes on plasma lipid composition, oxidative stress, blood pressure and inflammatory status in humans; (4) to determine if the antioxidants in the processed tomatoes will increase the human paraoxonase activity and concentration. The investigators hypothesize that: (1) consuming processed tomatoes frequently/daily will favorably improve endothelium and platelet function disease-risk biomarker profiles in adult men and women compared to consuming no or relatively low amounts of processed tomatoes; (2) consuming processed tomatoes frequently/daily to produce a stable background intake of processed tomatoes compared to no/ low background intake of processed tomatoes will be required to attenuate vaso-constrictive and platelet aggregatory effects of a standard high fat meal. Consuming a background diet low in processed tomatoes will require a single serving of processed tomatoes to be eaten concurrently to attenuate the vaso-constrictive and platelet aggregatory effects of the meal; (3) consuming processed tomatoes frequently/daily will improve blood pressure, the plasma lipid profile, oxidative stress and inflammatory status.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是：（1）比较高与低摄入量的加工番茄6周对内皮细胞和血小板功能的生物标志物的影响;（2）确定已知可诱导血小板聚集和减少血管收缩的高脂肪餐的作用是否与血小板聚集和血管收缩有关。人类的反应性受到加工番茄消费的背景摄入的影响，或者如果同时加工番茄消费是必要的，所述的标准高脂肪膳食的影响;（3）研究加工番茄的高消费与低消费对人类血浆脂质组成、氧化应激、血压和炎症状态的影响;（4）确定加工番茄中的抗氧化剂是否会增加人类对氧磷酶的活性和浓度。 研究人员假设：（1）与不食用或相对少量的加工番茄相比，经常/每天食用加工番茄将有利地改善成年男性和女性的内皮和血小板功能疾病风险生物标志物谱;（2）经常/每天食用加工番茄，以产生稳定的加工番茄背景摄入量，需要低背景摄入量的加工番茄来减弱标准高脂肪膳食的血管收缩和血小板聚集作用。食用加工番茄含量较低的背景饮食需要同时食用一份加工番茄，以减弱膳食的血管收缩和血小板聚集作用;（3）经常/每天食用加工番茄将改善血压、血脂谱、氧化应激和炎症状态。