BOLD (BEEF IN AN OPTIMAL LEAN DIET) EFFECTS ON ESTAB & EMERGING CVD RISK FACTOR

大胆（最佳瘦肉饮食中的牛肉）对建立的影响

• 批准号: 7951331
• 负责人: PENNY M KRIS-ETHERTON
• 金额: $ 13.91万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951331
• 关键词: American; Attenuated; Carbohydrates; Cardiovascular Diseases; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Crossover Design; DASH diet; Data; Diet; Epidemiology; Fatty acid glycerol esters; Funding; Grant; Heart; Incidence; Institution; Meat; Population; Process; Proteins; Reporting; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health; Woman; beef; blood glucose regulation; cardiovascular disorder risk; feeding; low density lipoprotein inhibitor; men; red meat consumption

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Several clinical trials have shown that the incorporation of lean red meat in a Step I or AHA diet does not attenuate the reduction of traditional risk factors for cardiovascular disease (CVD). However, epidemiological data consistently correlates increased red meat consumption with increased incidence of CVD, most likely due to the beef choice in the reported diets of fattier meat or processed meats. We are proposing a cross-over design controlled feeding study to evaluate the effects of the incorporation of lean red meat in a heart healthy (DASH type) diet on established and emerging CVD risk factors. Eighty men and women split into two distinct populations, moderate hypercholesterolemic and hypertriglyceridemic, will be assigned four different diets for five weeks each - average American control (50% carbohydrates, 16% protein, 22% fat), DASH (50% carbohydrates, 18% protein, 28% fat), BOLD (50% carbohydrates, 18% protein, 28% fat, 5-7oz lean red meat ), BOLD+ (44% carbohydrates, 28% protein, 28% fat, 5-7oz lean red meat). We hypothesize that the BOLD and BOLD+ diets will yield changes in LDL-C similar to that seen during the DASH diet period. We also hypothesize that the BOLD and BOLD+ diet periods will produce better effects on HDL-C, TG and glucose homeostasis.

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