BOLD (BEEF IN AN OPTIMAL LEAN DIET) EFFECTS ON ESTAB & EMERGING CVD RISK FACTOR

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 一些临床试验表明，在步骤I或AHA饮食中加入瘦肉红肉并不能减弱心血管疾病(CVD)传统风险因素的减少。然而，流行病学数据始终将红肉消费量的增加与心血管疾病发病率的增加联系在一起，这很可能是由于报告的较肥肉或加工肉类的饮食中选择了牛肉。我们提出了一项交叉设计的受控喂养研究，以评估在心脏健康(DASH类型)饮食中加入瘦肉红肉对既有和新出现的心血管疾病危险因素的影响。80名男性和女性被分成两个不同的人群，中度高胆固醇血症和高甘油三酯血症，每个人被分配四种不同的饮食，每人为期五周-平均美国对照组(50%碳水化合物，16%蛋白质，22%脂肪)，DASH(50%碳水化合物，18%蛋白质，28%脂肪)，BOLD(50%碳水化合物，18%蛋白质，28%脂肪，5-7盎司瘦红肉)，BOLD+(44%碳水化合物，28%蛋白质，28%脂肪，5-7盎司瘦红肉)。我们假设，大胆饮食和大胆+饮食将产生与DASH节食期类似的低密度脂蛋白-C的变化。我们还假设，大胆和大胆+节食期将对高密度脂蛋白胆固醇、甘油三酯和血糖稳态产生更好的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Several clinical trials have shown that the incorporation of lean red meat in a Step I or AHA diet does not attenuate the reduction of traditional risk factors for cardiovascular disease (CVD). However, epidemiological data consistently correlates increased red meat consumption with increased incidence of CVD, most likely due to the beef choice in the reported diets of fattier meat or processed meats. We are proposing a cross-over design controlled feeding study to evaluate the effects of the incorporation of lean red meat in a heart healthy (DASH type) diet on established and emerging CVD risk factors. Eighty men and women split into two distinct populations, moderate hypercholesterolemic and hypertriglyceridemic, will be assigned four different diets for five weeks each - average American control (50% carbohydrates, 16% protein, 22% fat), DASH (50% carbohydrates, 18% protein, 28% fat), BOLD (50% carbohydrates, 18% protein, 28% fat, 5-7oz lean red meat ), BOLD+ (44% carbohydrates, 28% protein, 28% fat, 5-7oz lean red meat). We hypothesize that the BOLD and BOLD+ diets will yield changes in LDL-C similar to that seen during the DASH diet period. We also hypothesize that the BOLD and BOLD+ diet periods will produce better effects on HDL-C, TG and glucose homeostasis.