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PROTEOMICS ANALYSIS OF SCHISTOSOME HOST-INVASION AND METABOLISM

PROTEOMICS ANALYSIS OF SCHISTOSOME HOST-INVASION AND METABOLISM
血吸虫宿主入侵和代谢的蛋白质组学分析
批准号：
7957388
负责人：
James H. McKerrow
金额：
$0.49万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-06-01 至 2010-05-31
来源：
https://reporter.nih.gov/project-details/7957388
关键词：
Computer Retrieval of Information on Scientific Projects DatabaseFundingGrantHumanIncubatedInstitutionLarvaMass Spectrum AnalysisMetabolismPeptide HydrolasesProteomicsResearchResearch PersonnelResourcesSchistosomaSkinSourceUnited States National Institutes of Healthresearch study

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中文摘要
翻译
这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在这些实验中，我们正试图确定皮肤中入侵性寄生虫幼虫蛋白酶的天然底物。将血吸虫尾蚴与人皮肤切片一起孵育，并提取降解产物。
英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In these experiments, we are attempting to identify the natural substrates for the protease of invasive schistosome larvae in skin. Schistosome cercariae are incubated with sections of human skin and products of degradation extracted.
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会议论文
Evaluation of a cathepsin S inhibitor as a potential drug for Chagas disease
HYDROLYSIS OF HEMOGLOBIN BY SCHISTSOMA MANSONI CATHEPSIN B-LIKE CYSTEINEPROTEASE
STRUCTURE BASED DRUG DESIGN FOR TREATMENT OF PARASITIC AND VIRAL DISEASES
GIARDIA LAMBLIA CYSTEINE PROTEASES: TRAFFICKING, LOCALIZATION, AND FUNCTION
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