SINGLE PARTICLE RECONSTRUCTION SOFTWARE DEVELOPMENT (EMAN)

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 EMAN是一个用于执行单粒子重建的软件套件。处理单个分子或大分子组装体的图像以产生3D重建。该工具包还包含用于2-D和动力学分析以及通用图像处理的工具。虽然EMAN/EMAN 2的核心开发由独立的R 01资助，但在P41的支持下，我们继续开发新的算法，以扩展使用该技术进行重建的分辨率，并探索新的研究领域，例如使用单粒子分析来研究大分子动力学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. EMAN is a software suite for performing single particle reconstructions. Images of individual molecules or macromolecular assemblies are processed to produce 3-D reconstructions. This toolkit also contains tools for 2-D and dynamics analysis as well as generic image processing. While the core development of EMAN/EMAN2 is funded by an independent R01, under P41 support we continue to develop new algorithms to extend the resolution of the reconstructions possible using this technique, and to explore new research areas, such as using single particle analysis for studying macromolecular dynamics.