SINGLE PARTICLE RECONSTRUCTION SOFTWARE DEVELOPMENT (EMAN)

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 EMAN是一个用于执行单粒子重建的软件套件。处理单个分子或大分子组装体的图像以产生3D重建。该工具包还包含用于2-D和动力学分析以及通用图像处理的工具。虽然EMAN/EMAN 2的核心开发由独立的R 01资助，但在P41的支持下，我们继续开发新的算法，以扩展使用该技术进行重建的分辨率，并探索新的研究领域，例如使用单粒子分析来研究大分子动力学。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. EMAN is a software suite for performing single particle reconstructions. Images of individual molecules or macromolecular assemblies are processed to produce 3-D reconstructions. This toolkit also contains tools for 2-D and dynamics analysis as well as generic image processing. While the core development of EMAN/EMAN2 is funded by an independent R01, under P41 support we continue to develop new algorithms to extend the resolution of the reconstructions possible using this technique, and to explore new research areas, such as using single particle analysis for studying macromolecular dynamics.