COLANDER: A PROBABILITY-BASED SUPPORT VECTOR MACHINE ALGORITHM FOR AUTOMATIC SCR
COLANDER: A PROBABILITY-BASED SUPPORT VECTOR MACHINE ALGORITHM FOR AUTOMATIC SCR
批准号:
7957740
负责人:
JOHN L YATES
金额:
$2.09万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-09-01 至 2010-08-31
关键词:
AlgorithmsBiologyCellsComputer Retrieval of Information on Scientific Projects DatabaseData SetDatabasesDiagnosticFundingFungal GenomeGrantInstitutionIonsMachine LearningMass Spectrum AnalysisPhosphopeptidesProbabilityProteolysisResearchResearch PersonnelResourcesSourceTimeTissuesTrainingUnited States National Institutes of Healthbaseprogramsresearch studystatistics
中文摘要
该子项目是利用
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得主要资金,
因此可以在其他CRISP条目中表示。列出的机构是
中心,不一定是研究者的机构。
我们开发了一个基于概率的机器学习程序,Colander,以确定串联质谱,很可能代表磷酸肽数据库搜索之前。基于离子阱CID MS/MS实验,我们确定了磷酸肽串联质谱的统计学显著诊断特征。从376个经验证的磷酸肽光谱和376个非磷酸肽光谱计算特征的统计。一个基于概率的支持向量机(SVM)程序,Colander,然后训练五个选定的功能。从LC/LC-MS/MS分析蛋白水解细胞、组织和合成磷酸肽的大规模磷酸肽富集物中收集数据集。这些数据集用于评价Colander选择含pS/pT磷酸肽串联质谱的能力。当应用于未知的串联质谱时,Colander可以常规地去除80%的串联质谱,同时保留95%的磷酸肽串联质谱。该程序将数据库搜索的计算时间显著减少了60- 90%。此外,代表磷酸肽的预过滤串联质谱可以在预定义的假阳性率下增加磷酸肽鉴定的数量。
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
We developed a probability-based machine-learning program, Colander, to identify tandem mass spectra that are highly likely to represent phosphopeptides prior to database search. We identified statistically significant diagnostic features of phosphopeptide tandem mass spectra based on ion trap CID MS/MS experiments. Statistics for the features are calculated from 376 validated phosphopeptide spectra and 376 nonphosphopeptide spectra. A probability-based support vector machine (SVM) program, Colander, was then trained on five selected features. Data sets were assembled both from LC/LC-MS/MS analyses of large-scale phosphopeptide enrichments from proteolyzed cells, tissues and synthetic phosphopeptides. These data sets were used to evaluate the capability of Colander to select pS/pT-containing phosphopeptide tandem mass spectra. When applied to unknown tandem mass spectra, Colander can routinely remove 80% of tandem mass spectra while retaining 95% of phosphopeptide tandem mass spectra. The program significantly reduced computational time spent on database search by 60-90%. Furthermore, prefiltering tandem mass spectra representing phosphopeptides can increase the number of phosphopeptide identifications under a predefined false positive rate.
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会议论文
INVESTIGATION OF THE POROUS LAYER OPEN TUBULAR (PLOT) REVERSE PHASE COLUMN
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批准号:7957760
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项目类别:
-
资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
A HUPO TEST SAMPLE STUDY REVEALS COMMON PROBLEMS IN MASS SPECTROMETRY-BASED PROT
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批准号:7957726
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项目类别:
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资助金额:$0.33万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
GENOME ANNOTATION BY MASS SPECTROMETRY
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批准号:7957688
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项目类别:
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资助金额:$0.33万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
IDENTIFYING DIFFERENCES IN PROTEIN EXPRESSION LEVELS BY SPECTRAL COUNTING AND FE
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批准号:7957728
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
CUSTOM DATA ACQUISITION USING THERMOELECTRON CONTROL OBJECT MODEL (COM) LIBRARY
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批准号:7957761
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
LABEL-FREE QUANTIFICATION VIA IMPROVED CHROMATOGRAPHIC ELUTION REPRODUCIBILITY
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批准号:7957762
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
EVALUATION OF LTQ-ORBITRAP
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批准号:7957739
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
ANALYSIS OF ORGANELLES BY ON-LINE TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY-TANDEM M
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批准号:7957738
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项目类别:
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资助金额:$0.33万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
SEMINARS GIVEN BY JOHN R YATES III
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批准号:7957693
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项目类别:
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资助金额:$1.3万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
ETD CHARGE PREDICTION MACHINE
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批准号:7957731
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
CAPILLARY ELECTROPHORESIS - MASS SPECTROMETRY ON PROTEOMIC ANALYSIS
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批准号:7957723
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
MOTIF-SPECIFIC SAMPLING OF PHOSPHOPROTEOMES
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批准号:7957767
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
COMPARISONS OF MASS SPECTROMETRY COMPATIBLE SURFACTANTS FOR GLOBAL ANALYSIS OF T
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批准号:7957724
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项目类别:
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资助金额:$0.33万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
IMPROVING PROTEIN IDENTIFICATION SENSITIVITY BY COMBINING MS AND MS/MS
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批准号:7957770
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
PROTEOMIC ANALYSIS OF ZYGOTE AND OOKINETE STAGES OF THE AVIAN MALARIA PARASITE P
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批准号:7957733
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项目类别:
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资助金额:$0.33万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
SALIVARY GLAND EXOSOME PROTEOME
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批准号:7957758
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项目类别:
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资助金额:$0.33万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
MASS SPECTROMETRY FOR PROTEOMICS
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批准号:7957667
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项目类别:
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资助金额:$0.33万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
PATTERNLAB FOR PROTEOMICS: A TOOL FOR DIFFERENTIAL SHOTGUN PROTEOMICS
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批准号:7957737
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
METHOD DEVELOPMENT FOR MEMBRANE PROTEIN ANALYSIS
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批准号:7957769
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项目类别:
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资助金额:$2.09万
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财政年份:2009
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负责人:JOHN L YATES
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依托单位:
FUNCTIONS OF EPSTEIN-BARR VIRUS NUCLEAR ANTIGEN 1
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批准号:2091089
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项目类别:
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资助金额:$18.11万
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财政年份:1986
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负责人:JOHN L YATES
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依托单位:
国内基金
海外基金
Journal of Integrative Plant Biology
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批准号:31024801
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项目类别:专项基金项目
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资助金额:24.0万元
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批准年份:2010
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负责人:贺萍
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依托单位: