FDTD MODELING OF LIGHT SCATTERING FROM CELLS AND TISSUES

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们希望将我们的有限差分时域（FDTD）建模的光散射从细胞到虚拟组织模拟器的方面。FDTD方法是一种电磁方法，能够在亚微米尺度上精确建模细胞和其他组织成分的完整光散射特性。虽然FDTD模拟计算要求很高，但应该可以为各种各样的细胞结构和成分创建散射截面和相函数的数据库，这些结构和成分可以纳入宏观蒙特卡罗方法。这种方法将使用户能够指定组织成分的细胞和亚细胞特征，然后研究微观参数的变化如何转化为宏观光学变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We would like to incorporate aspects of our finite difference time-domain (FDTD) modeling of light scattering from cells into the Virtual Tissue Simulator. The FDTD method is an electromagnetic approach that enables accurate modeling of the complete light scattering properties of cells and other tissue components at the sub-micron scale. Although FDTD simulations are computationally demanding, it should be possible to create a database of scattering cross-sections and phase functions for a wide range of cellular structures and compositions that could be incorporated into macroscopic Monte Carlo methods. Such an approach would enable users to specify cellular and sub-cellular features of tissue components and then investigate how changes in the microscopic parameters translate to macroscopic optical changes.