FDTD MODELING OF LIGHT SCATTERING FROM CELLS AND TISSUES

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们希望将我们对细胞光散射的时域有限差分(FDTD)建模的各个方面整合到虚拟组织模拟器中。FDTD方法是一种电磁方法，能够在亚微米尺度上精确模拟细胞和其他组织成分的完整光散射特性。虽然FDTD模拟对计算要求很高，但它应该可以为各种蜂窝结构和成分创建一个散射截面和相函数的数据库，并将其整合到宏观蒙特卡罗方法中。这种方法将使用户能够指定组织成分的细胞和亚细胞特征，然后研究微观参数的变化如何转化为宏观光学变化。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We would like to incorporate aspects of our finite difference time-domain (FDTD) modeling of light scattering from cells into the Virtual Tissue Simulator. The FDTD method is an electromagnetic approach that enables accurate modeling of the complete light scattering properties of cells and other tissue components at the sub-micron scale. Although FDTD simulations are computationally demanding, it should be possible to create a database of scattering cross-sections and phase functions for a wide range of cellular structures and compositions that could be incorporated into macroscopic Monte Carlo methods. Such an approach would enable users to specify cellular and sub-cellular features of tissue components and then investigate how changes in the microscopic parameters translate to macroscopic optical changes.