PERTURBATION MONTE CARLO TECHNIQUES FOR DIFFUSE PHOTON MIGRATION

漫射光子迁移的扰动蒙特卡洛技术

• 批准号: 8362599
• 负责人: VASAN VENUGOPALAN
• 金额: $ 0.47万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362599
• 关键词: Algorithms; Biotechnology; Complex; Development; Diffuse; Funding; Grant; Heterogeneity; Lasers; Methods; National Center for Research Resources; Optics; Photons; Principal Investigator; Property; Research; Research Infrastructure; Resources; Signal Transduction; Solutions; Source; Techniques; Tissues; United States National Institutes of Health; cost; migration; novel; simulation

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Development has continued of a novel and efficient method to provide solutions to inverse photon migration problems in heterogeneous turbid media. The method extracts derivative information from a single Monte Carlo simulation to permit the rapid determination of rates of change in the detected photon signal with respect to perturbations in background tissue optical properties. We then supply the derivative information to a nonlinear optimization algorithm to determine the optical properties of the tissue heterogeneity under consideration. We have demonstrated this approach in two layered media as well as more complex tissue geometries descriptive of particular applications.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 一种新的和有效的方法的发展继续提供解决方案，在非均匀混浊介质中的逆光子迁移问题。该方法提取衍生信息从一个单一的蒙特卡罗模拟，以允许快速确定检测到的光子信号的变化率相对于扰动的背景组织光学特性。然后，我们提供的衍生信息的非线性优化算法，以确定所考虑的组织异质性的光学特性。我们已经证明了这种方法在两层介质以及更复杂的组织几何形状描述的特定应用程序。