MONTE CARLO METHODS FOR FIBER OPTIC PROBE DESIGN
光纤探头设计的蒙特卡罗方法
基本信息
- 批准号:8362661
- 负责人:
- 金额:$ 0.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-04-01 至 2012-03-31
- 项目状态:已结题
- 来源:
- 关键词:BiotechnologyCaliberCancer DetectionCollectionDevelopmentEndoscopesEpithelialEpitheliumFiberFiber OpticsFundingGoalsGrantHumanLasersLeadLightingMalignant NeoplasmsMonitorMonte Carlo MethodMorphologyNational Center for Research ResourcesOpticsPrincipal InvestigatorPropertyReportingResearchResearch InfrastructureResolutionResourcesSourceSpectrum AnalysisTestingTimeUnited States National Institutes of Healthcarcinogenesiscostdesigndetectorin vivoinstrumentnovelsimulation
项目摘要
This subproject is one of many research subprojects utilizing the resources
provided by a Center grant funded by NIH/NCRR. Primary support for the subproject
and the subproject's principal investigator may have been provided by other sources,
including other NIH sources. The Total Cost listed for the subproject likely
represents the estimated amount of Center infrastructure utilized by the subproject,
not direct funding provided by the NCRR grant to the subproject or subproject staff.
The main goal of this project is to use Monte Carlo simulations in development of novel fiber optic endoscopes that can simultaneously probe the epithelial and stromal morphology using oblique collection fiber geometry. We will use previously reported scattering properties of human epithelium to predict and to characterize collection efficiency and depth resolution of different probe designs. Design parameters will include source-detector separation; various angles between illumination and collection fibers; fiber diameter; number of collection fibers, etc. We will change optical properties of the epithelium to reflect early cancer development and will optimize probe design to achieve the highest sensitivity to optical changes that are associated with an onset of carcinogenesis. Theoretical predictions will be tested using well defined multi-layered optical phantoms of human epithelium. Successful completion of the project can lead to development of a simple instrument for non-invasive, real time in vivo pre-cancer detection and monitoring via reflectance spectroscopy.
这个子项目是利用资源的许多研究子项目之一。
由NIH/NCRR资助的中心拨款提供。对子项目的主要支持
子项目的首席调查员可能是由其他来源提供的,
包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能
表示该子项目使用的中心基础设施的估计数量,
不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。
该项目的主要目标是使用蒙特卡罗模拟来开发新型光纤内窥镜,这种内窥镜可以利用倾斜收集纤维的几何形状同时探测上皮和间质的形态。我们将使用以前报道的人类上皮的散射特性来预测和表征不同探针设计的收集效率和深度分辨率。设计参数将包括源-探测器分离;照明和收集纤维之间的不同角度;纤维直径;收集纤维的数量等。我们将改变上皮的光学属性,以反映癌症的早期发展,并将优化探头设计,以实现对与癌症发生相关的光学变化的最高灵敏度。理论预测将使用定义良好的人体上皮多层光学模体进行验证。该项目的成功完成将导致开发一种简单的仪器,用于通过反射光谱进行非侵入性的、活体实时的癌前检测和监测。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
VASAN VENUGOPALAN其他文献
VASAN VENUGOPALAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('VASAN VENUGOPALAN', 18)}}的其他基金
A Biophotonics Platform for Mechanotransduction and Metabolic Microscopy
用于机械传导和代谢显微镜的生物光子学平台
- 批准号:
10378760 - 财政年份:2019
- 资助金额:
$ 0.45万 - 项目类别:
GREEN?S FUNCTION OF THE BOLTZMANN EQUATION TO SOLVE PROBLEMS IN PHOTON MIGRATION
玻尔兹曼方程的格林函数解决光子迁移问题
- 批准号:
8362622 - 财政年份:2011
- 资助金额:
$ 0.45万 - 项目类别:
FDTD MODELING OF LIGHT SCATTERING FROM CELLS AND TISSUES
细胞和组织光散射的 FDTD 建模
- 批准号:
8362642 - 财政年份:2011
- 资助金额:
$ 0.45万 - 项目类别:
PERTURBATION MONTE CARLO TECHNIQUES FOR DIFFUSE PHOTON MIGRATION
漫射光子迁移的扰动蒙特卡洛技术
- 批准号:
8362599 - 财政年份:2011
- 资助金额:
$ 0.45万 - 项目类别:
POISE: A NOVEL APPROACH FOR DETERMINING OPTICAL PROPERTIES OF TURBID MEDIA
Poise:一种确定浑浊介质光学特性的新方法
- 批准号:
8362621 - 财政年份:2011
- 资助金额:
$ 0.45万 - 项目类别:
DEVELOPMENT OF DELTA P1 & HIGHER ORDER DIFFUSE MODELS FOR FDPM
台达P1的发展
- 批准号:
8362595 - 财政年份:2011
- 资助金额:
$ 0.45万 - 项目类别:
MONTE CARLO METHODS FOR FIBER OPTIC PROBE DESIGN
光纤探头设计的蒙特卡罗方法
- 批准号:
8169490 - 财政年份:2010
- 资助金额:
$ 0.45万 - 项目类别:
DEVELOPMENT OF DELTA P1 & HIGHER ORDER DIFFUSE MODELS FOR FDPM
台达P1的发展
- 批准号:
8169424 - 财政年份:2010
- 资助金额:
$ 0.45万 - 项目类别:
PERTURBATION MONTE CARLO TECHNIQUES FOR DIFFUSE PHOTON MIGRATION
漫射光子迁移的扰动蒙特卡洛技术
- 批准号:
8169428 - 财政年份:2010
- 资助金额:
$ 0.45万 - 项目类别:
相似海外基金
Functional evaluation of bioabsorbable small-caliber vascular graft in a diabetic rat model to achieve a practical use
生物可吸收小口径血管移植物在糖尿病大鼠模型中的功能评价以实现实用化
- 批准号:
21K08812 - 财政年份:2021
- 资助金额:
$ 0.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
CALIBER: Conductive Additives to reduce Lithium Ion Battery Electrode Resistance
CALIBER:降低锂离子电池电极电阻的导电添加剂
- 批准号:
10004505 - 财政年份:2021
- 资助金额:
$ 0.45万 - 项目类别:
BEIS-Funded Programmes
Enhanced degradability of bioabsorbable small-caliber artificial vessels to promote autologous vascular regeneration
增强生物可吸收小口径人工血管的降解性促进自体血管再生
- 批准号:
21K20938 - 财政年份:2021
- 资助金额:
$ 0.45万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Engineering a biomimetic small caliber vascular prosthesis: fabrication of an anti-thrombogenic endothelium from the stromal vascular fraction of adipose tissue
设计仿生小口径血管假体:从脂肪组织的基质血管部分制造抗血栓内皮
- 批准号:
518445-2018 - 财政年份:2020
- 资助金额:
$ 0.45万 - 项目类别:
Postgraduate Scholarships - Doctoral
Elucidation of the mechanism of small caliber axons' myelination in the central nervous system and its application
中枢神经系统小口径轴突髓鞘化机制的阐明及其应用
- 批准号:
20K07756 - 财政年份:2020
- 资助金额:
$ 0.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Morphological and Biochemical Profiling of the Degeneration of Small Caliber Axons Using a Murine Model for Myelin-related Diseases
使用髓磷脂相关疾病的小鼠模型对小口径轴突变性进行形态学和生化分析
- 批准号:
20KK0188 - 财政年份:2020
- 资助金额:
$ 0.45万 - 项目类别:
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
In vitro endothelialization of small caliber vascular prostheses made of bacterial nanocellulose depending on coating with albumin, fibronectin or heparin
由细菌纳米纤维素制成的小口径血管假体的体外内皮化取决于白蛋白、纤连蛋白或肝素的涂层
- 批准号:
421965288 - 财政年份:2019
- 资助金额:
$ 0.45万 - 项目类别:
Research Grants
Engineering a biomimetic small caliber vascular prosthesis: fabrication of an anti-thrombogenic endothelium from the stromal vascular fraction of adipose tissue
设计仿生小口径血管假体:从脂肪组织的基质血管部分制造抗血栓内皮
- 批准号:
518445-2018 - 财政年份:2019
- 资助金额:
$ 0.45万 - 项目类别:
Postgraduate Scholarships - Doctoral
Anti-atherosclerotic action of platelet-derived endothelial cell growth factor to improve patency of small-caliber artificial blood vessels
血小板源性内皮细胞生长因子的抗动脉粥样硬化作用可改善小口径人造血管的通畅性
- 批准号:
18K08753 - 财政年份:2018
- 资助金额:
$ 0.45万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Engineering a biomimetic small caliber vascular prosthesis: fabrication of an anti-thrombogenic endothelium from the stromal vascular fraction of adipose tissue
设计仿生小口径血管假体:从脂肪组织的基质血管部分制造抗血栓内皮
- 批准号:
518445-2018 - 财政年份:2018
- 资助金额:
$ 0.45万 - 项目类别:
Postgraduate Scholarships - Doctoral