DEVELOPMENT OF DELTA P1 & HIGHER ORDER DIFFUSE MODELS FOR FDPM

台达P1的发展

• 批准号: 8169424
• 负责人: VASAN VENUGOPALAN
• 金额: $ 2.68万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169424
• 关键词: Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diffuse; Diffusion; Equation; Funding; Grant; Institution; Measurement; Modeling; Process; Property; Research; Research Personnel; Resources; Solutions; Source; Structure; Surface; Theoretical model; Tissues; United States National Institutes of Health; base; detector; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing the delta-P1 and higher order diffusion based models to allow accurate processing of FDPM data in a broader number of clinical situations. Specifically, are making FDPM measurements to probe layered tissue structures as well as assess the properties of small tissue volumes. In both these applications, we require FDPM measurements to be made at small source-detector (S-D) separations. These delta-P1 and higher order diffusion based models accommodate spatially distributed collimated sources and provide accurate predictions at small s-d separations and over a broad range of albedo. We will compare these results to solutions derived using the standard diffusion approximation and experiment. We will also solve the new equations for steady and amplitude modulated collimated sources illuminating the surface of an infinite medium. Compare results with SODT and experiment. We are currently investigating the use of this theoretical models to solve th e in verse problem at small s-d separations.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 我们正在开发基于 delta-P1 和高阶扩散的模型，以便能够在更广泛的临床情况下准确处理 FDPM 数据。 具体来说，正在进行 FDPM 测量，以探测分层组织结构并评估小组织体积的特性。 在这两种应用中，我们都要求在较小的源-探测器 (S-D) 间距下进行 FDPM 测量。这些基于 delta-P1 和高阶扩散的模型可适应空间分布的准直源，并在较小的 s-d 间隔和较宽的反照率范围内提供准确的预测。 我们将这些结果与使用标准扩散近似和实验得出的解决方案进行比较。 我们还将求解照明无限介质表面的稳定调幅准直源的新方程。 将结果与 SODT 和实验进行比较。 我们目前正在研究使用该理论模型来解决小 s-d 分离的逆问题。