DEVELOPMENT OF DELTA P1 & HIGHER ORDER DIFFUSE MODELS FOR FDPM

台达P1的发展

• 批准号: 8169424
• 负责人: VASAN VENUGOPALAN
• 金额: $ 2.68万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169424
• 关键词: Clinical; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Diffuse; Diffusion; Equation; Funding; Grant; Institution; Measurement; Modeling; Process; Property; Research; Research Personnel; Resources; Solutions; Source; Structure; Surface; Theoretical model; Tissues; United States National Institutes of Health; base; detector; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing the delta-P1 and higher order diffusion based models to allow accurate processing of FDPM data in a broader number of clinical situations. Specifically, are making FDPM measurements to probe layered tissue structures as well as assess the properties of small tissue volumes. In both these applications, we require FDPM measurements to be made at small source-detector (S-D) separations. These delta-P1 and higher order diffusion based models accommodate spatially distributed collimated sources and provide accurate predictions at small s-d separations and over a broad range of albedo. We will compare these results to solutions derived using the standard diffusion approximation and experiment. We will also solve the new equations for steady and amplitude modulated collimated sources illuminating the surface of an infinite medium. Compare results with SODT and experiment. We are currently investigating the use of this theoretical models to solve th e in verse problem at small s-d separations.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们正在开发Delta-P1和高阶扩散模型，以便在更广泛的临床情况下准确处理FDPM数据。 具体而言，正在对探针分层组织结构进行FDPM测量以及评估小组织体积的特性。 在这两个应用程序中，我们都需要在小源探测器（S-D）分离处进行FDPM测量。这些Delta-P1和高阶基于扩散的模型可容纳空间分布的准直源，并在小S-D分离和广泛的反照率上提供准确的预测。 我们将将这些结果与使用标准扩散近似和实验得出的溶液进行比较。 我们还将解决新方程，以稳定和振幅调制的准直源照明无限介质的表面。 将结果与SODT和实验进行比较。 我们目前正在研究这种理论模型在小s-d分离中解决经文问题的使用。