DEVELOPMENT OF DELTA P1 & HIGHER ORDER DIFFUSE MODELS FOR FDPM

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 我们正在开发基于delta-P1和高阶扩散的模型，以便在更广泛的临床情况下准确处理FDPM数据。 具体而言，进行FDPM测量以探测分层组织结构以及评估小组织体积的特性。 在这两种应用中，我们都要求在小的源-探测器（S-D）间隔下进行FDPM测量。这些基于delta-P1和高阶扩散的模型可适应空间分布的准直源，并在小s-d分离和宽范围的散射比下提供准确的预测。 我们将这些结果与使用标准扩散近似和实验得到的解进行比较。 我们还将解决新的方程稳定和振幅调制准直光源照明的表面的一个无限的介质。 并与SODT和实验结果进行比较。 我们目前正在研究使用这种理论模型来解决小s-d分离时的反问题。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are developing the delta-P1 and higher order diffusion based models to allow accurate processing of FDPM data in a broader number of clinical situations. Specifically, are making FDPM measurements to probe layered tissue structures as well as assess the properties of small tissue volumes. In both these applications, we require FDPM measurements to be made at small source-detector (S-D) separations. These delta-P1 and higher order diffusion based models accommodate spatially distributed collimated sources and provide accurate predictions at small s-d separations and over a broad range of albedo. We will compare these results to solutions derived using the standard diffusion approximation and experiment. We will also solve the new equations for steady and amplitude modulated collimated sources illuminating the surface of an infinite medium. Compare results with SODT and experiment. We are currently investigating the use of this theoretical models to solve th e in verse problem at small s-d separations.