DEVELOPMENT OF DELTA P1 & HIGHER ORDER DIFFUSE MODELS FOR FDPM

台达P1的发展

基本信息

批准号：
8362595
负责人：
VASAN VENUGOPALAN
金额：
$ 2.49万
依托单位：
UNIVERSITY OF CALIFORNIA-IRVINE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2012-03-31
项目状态：
已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are developing the delta-P1 and higher order diffusion based models to allow accurate processing of FDPM data in a broader number of clinical situations. Specifically, are making FDPM measurements to probe layered tissue structures as well as assess the properties of small tissue volumes. In both these applications, we require FDPM measurements to be made at small source-detector (S-D) separations. These delta-P1 and higher order diffusion based models accommodate spatially distributed collimated sources and provide accurate predictions at small s-d separations and over a broad range of albedo. We will compare these results to solutions derived using the standard diffusion approximation and experiment. We will also solve the new equations for steady and amplitude modulated collimated sources illuminating the surface of an infinite medium. Compare results with SODT and experiment. We are currently investigating the use of this theoretical models to solve th e in verse problem at small s-d separations.

该副本是利用资源的众多研究子项目之一由NIH/NCRR资助的中心赠款提供。对该子弹的主要支持而且，副投影的主要研究员可能是其他来源提供的包括其他NIH来源。列出的总费用可能代表subproject使用的中心基础架构的估计量， NCRR赠款不直接向子弹或副本人员提供的直接资金。我们正在开发Delta-P1和高阶扩散模型，以便在更广泛的临床情况下准确处理FDPM数据。具体而言，正在对探针分层组织结构进行FDPM测量以及评估小组织体积的特性。在这两个应用程序中，我们都需要在小源探测器（S-D）分离处进行FDPM测量。这些Delta-P1和高阶基于扩散的模型可容纳空间分布的准直源，并在小S-D分离和广泛的反照率上提供准确的预测。我们将将这些结果与使用标准扩散近似和实验得出的溶液进行比较。我们还将解决新方程，以稳定和振幅调制的准直源照明无限介质的表面。将结果与SODT和实验进行比较。我们目前正在研究这种理论模型在小s-d分离中解决经文问题的使用。