DEVELOPMENT OF DELTA P1 & HIGHER ORDER DIFFUSE MODELS FOR FDPM

台达P1的发展

• 批准号: 8362595
• 负责人: VASAN VENUGOPALAN
• 金额: $ 2.49万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8362595
• 关键词: Biotechnology; Clinical; Data; Development; Diffuse; Diffusion; Equation; Funding; Grant; Lasers; Measurement; Modeling; National Center for Research Resources; Principal Investigator; Process; Property; Research; Research Infrastructure; Resources; Solutions; Source; Structure; Surface; Theoretical model; Tissues; United States National Institutes of Health; base; cost; detector; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are developing the delta-P1 and higher order diffusion based models to allow accurate processing of FDPM data in a broader number of clinical situations. Specifically, are making FDPM measurements to probe layered tissue structures as well as assess the properties of small tissue volumes. In both these applications, we require FDPM measurements to be made at small source-detector (S-D) separations. These delta-P1 and higher order diffusion based models accommodate spatially distributed collimated sources and provide accurate predictions at small s-d separations and over a broad range of albedo. We will compare these results to solutions derived using the standard diffusion approximation and experiment. We will also solve the new equations for steady and amplitude modulated collimated sources illuminating the surface of an infinite medium. Compare results with SODT and experiment. We are currently investigating the use of this theoretical models to solve th e in verse problem at small s-d separations.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们正在开发基于delta-P1和高阶扩散的模型，以便在更广泛的临床情况下准确处理FDPM数据。 具体而言，进行FDPM测量以探测分层组织结构以及评估小组织体积的特性。 在这两种应用中，我们都要求在小的源-探测器（S-D）间隔下进行FDPM测量。这些基于delta-P1和更高阶扩散的模型适应空间分布的准直源，并在小s-d分离和广泛的反照率范围内提供准确的预测。 我们将这些结果与使用标准扩散近似和实验得到的解进行比较。 我们还将解决新的方程稳定和振幅调制准直光源照明的表面的一个无限的介质。 并与SODT和实验结果进行比较。 我们目前正在研究使用这种理论模型来解决小s-d分离时的反问题。