STRUCTURE OF AMORPHOUS METAL-HALOGEN BIOMATERIALS IN ARTHROPOD TOOLS

节肢动物工具中非晶金属卤生物材料的结构

• 批准号: 7954214
• 负责人: ROBERT A SCOTT
• 金额: $ 1.51万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7954214
• 关键词: Anabolism; Arthropods; Biochemistry; Biocompatible Materials; Biology; Chemistry; Claw; Computer Retrieval of Information on Scientific Projects Database; Deposition; Development; Fluorescence; Funding; Grant; Halogens; Image; Institution; Jaw; Metals; Microscopy; Research; Research Personnel; Resolution; Resources; Source; Spatial Distribution; Spectrum Analysis; Sting Injury; Structure; Transition Elements; United States National Institutes of Health; absorption; beamline; research study; structural biology; synchrotron radiation; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to use x-ray absorption spectroscopy to characterize the metal-halogen biomaterials that are biosynthesized in the cuticular tools of most arthropods and a few other phyla. Maturation of these cuticular tools (fangs, stings, jaws, claws, etc.) involves the transport and deposition of transition metals (Mn, Fe, Cu, Zn) and halogens (Cl, Br, I) in amorphous structures that cannot be characterized by x-ray diffraction. We expect to uncover new biology, biochemistry, and materials chemistry in determining the structures and spatial distribution of these biomaterials during biosynthesis and maturation of these tools. Bulk XAS, followed by imaging and x-ray microscopy will allow detailed structural analysis. These experiments range from the straightforward (transition metal bulk XAS by fluorescence excitation) to the challenging (low-energy imaging at micron spatial resolution) that will take advantage of beamline developments for SPEAR3.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们建议使用X射线吸收光谱来表征在大多数节肢动物的表皮工具和其他一些门中生物合成的金属释放生物材料。这些表皮工具（方形，刺，颌骨，爪等）的成熟涉及在无法通过X射线衍射表征的无定形结构中过渡金属（Mn，Fe，Cu，Zn）和卤素（Cl，Br，I）的转运和沉积。我们希望在这些工具的生物合成和成熟过程中确定这些生物材料的结构和空间分布，以确定这些生物材料的结构和空间分布，从而发现新的生物学，生物化学和材料化学。大量XAS，然后进行成像和X射线显微镜，将允许详细的结构分析。这些实验范围从直接的（通过荧光激发过渡金属XAS）到具有挑战性的（微米空间分辨率下的低能成像），这些（将利用Spear3的光束线开发）。