Social and geographic predictors of heterogeneity in cardiovascular risk in Afric

多项研究比较了非裔美国人的心血管危险因素和心血管结局 和白人人口。这些比较隐含地假设种族/民族之间的风险相对相同。 组。尽管很少有研究明确研究非洲人心血管风险的异质性 美国人，有证据表明心血管死亡率、亚临床动脉粥样硬化和其他 心血管危险因素表现出重要的异质性，通常与社会和地理有关 各种因素。了解与这种异质性相关的因素对于减轻 非裔美国人的心血管疾病和缩小健康差距。杰克逊心脏研究 (JHS)，其庞大的样本量、最先进的数据收集、广泛的社会文化评估以及 详细的行为和生物测量提供了一个独特的机会来检查 非裔美国人队列中心血管风险的异质性。这个项目的总体目标是 研究非裔美国人心血管风险异质性的社会和地理预测因素。 这一目标将通过分析杰克逊心脏研究的数据并通过比较 杰克逊的数据是从居住在美国其他地区的非裔美国人那里获得的类似收集的数据 参与动脉粥样硬化多民族研究的国家。具体目标是：(1)审视社会 杰克逊心脏研究中确定的心血管危险因素和心血管事件的预测因素。 (2)考察在非裔美国人中特别相关的心理社会措施的贡献 人口(如歧视、约翰·亨利西姆和慢性压力)对 心血管危险因素和心血管结局。此外，我们还将检查行为 这些社会和心理社会影响的生物机制包括 与应激反应相关或受应激反应影响的生物标志物，如血清皮质醇、血压、 腹型肥胖、胰岛素抵抗和炎症标志物。(3)检查地理上的可变性 风险因素和生物标志物；以及(4)确定是否观察到任何地理差异 可归因于社会因素的地理差异或社会因素与 风险因素。这些目标将通过密歇根大学和 杰克逊心脏研究(包括其两个合作伙伴杰克逊州立大学和密西西比大学 医疗中心)。除了科学目标之外，这个项目的一个主要目标是提高科学 JHS的一般生产力，特别强调提高JHS的能力和生产力 在杰克逊州立大学担任调查员，并促进少数族裔调查员的职业发展。

Multiple studies have compared cardiovascular risk factors and cardiovascular outcomes in African American and white populations. These comparisons implicitly assume relative homogeneity in risk within race/ethnic groups. Although few studies have explicitly investigated heterogeneity in cardiovascular risk within African Americans, there is evidence that cardiovascular mortality, subclinical atherosclerosis, and other cardiovascular risk factors exhibit important heterogeneity often associated with social and geographic factors. Understanding factors associated with this heterogeneity is important for reducing the burden of cardiovascular disease in African Americans and for reducing health disparities. The Jackson Heart Study (JHS), with its large sample size, state-of-the-art data collection, extensive socio-cultural assessment, and detailed behavioral and biological measures provides a unique opportunity to examine social determinants of heterogeneity in cardiovascular risk within an African American cohort. The overall goal of this project is to examine social and geographic predictors of heterogeneity in cardiovascular risk within African-Americans. This goal will be accomplished through analysis of data from the Jackson Heart Study and by comparing Jackson data to similarly collected data obtained from African Americans residing in other parts of the country participating in the Multi-Ethnic Study of Atherosclerosis. Specific aims are: (1) To examine social predictors of established cardiovascular risk factors and cardiovascular events in the Jackson Heart Study. (2) To examine the contribution of psychosocial measures of particular relevance in African American populations (such as discrimination, John Henrysim, and chronic stress) to the social patterning of cardiovascular risk factors and cardiovascular outcomes. In addition, we will also examine the behavioral and biological mechanisms through which these social and psychosocial effects operate including biomarkers associated with, or affected by, the stress response such serum cortisol, blood pressure, abdominal obesity, insulin resistance, and markers of inflammation. (3) To examine geographic variability in the risk factors and biological markers; and (4) To determine whether any geographic differences observed are attributable to geographic differences in social factors or in the relationship between social factors and risk factors. These Aims will be achieved through a collaboration between the University of Michigan and the Jackson Heart Study (including its two partners Jackson State University and the University of Mississippi Medical Center). In addition to the scientific aims, a major goal of this project is to enhance the scientific productivity of JHS generally, with a special emphasis on enhancing the capacity and productivity of JHS investigators at Jackson State and facilitating the career development of minority investigators.