Dental Implants with Improved Healing through Orientated Fluorapatite Coatings

通过定向氟磷灰石涂层改善愈合的牙种植体

• 批准号: 7999505
• 负责人: BRIAN H CLARKSON
• 金额: $ 21.29万
• 依托单位: MC3, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7999505
• 关键词: Adhesions; Adipose tissue; Animal Testing; Area; Back; Binding; Biomimetics; Bone Growth; Bone Regeneration; Bone Tissue; Businesses; Cells; Characteristics; Chemicals; Commit; Data; Dental Implants; Deposition; Devices; Disease; Employment; Exhibits; Failure; Fibroblasts; Film; Fluorides; Goals; Growth; Healed; Hydroxyapatites; Implant; Implantation procedure; In Vitro; Inflammatory Response; Lead; Licensing; Mandible; Manufacturer Name; Marketing; Maxilla; Mechanics; Metals; Methods; Michigan; Minerals; Modeling; Morbidity - disease rate; Mus; Natural regeneration; Nodule; Operative Surgical Procedures; Osseointegration; Osteocalcin; Osteoclasts; Osteogenesis; Patients; Phagocytes; Phase; Process; Property; Publishing; Recovery; Recruitment Activity; Research; Services; Small Business Innovation Research Grant; Smoker; Speed; Staging; Stem cells; Surface; System; Technology; Testing; Thick; Time; Tissues; Titanium; Universities; Work; biomaterial development; bone; bone quality; capsule; commercial application; commercialization; cost; experience; fluorapatite; healing; hip replacement arthroplasty; implant coating; improved; in vivo; member; osteogenic; pre-clinical; process optimization; protein expression; public health relevance; repaired; scale up; success; surface coating

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR project is to demonstrate the feasibility of applying a uniform, robust fluorapatite (FA) coating to dental implants that will help control the microenvironment after implant placement. The proprietary coating process involves growing well-aligned fluorapatite (FA) crystal films on etched surfaces. Preliminary data demonstrate that well-aligned FA crystal films have enhanced osteoblastic cell (MG-63) adhesion, proliferation and mineral formation compared to non-aligned (disordered) FA surfaces. The Phase I research plan proposes optimization of the coating process, to achieve a robust and repeatable coating on Titanium dental implants. Each step in the process will be carefully developed and verified. Tests will be conducted to assess the physical, chemical and mechanical properties of the FA covered surfaces. When a consistent coating has been achieved, the materials will be tested for pro-healing characteristics. PUBLIC HEALTH RELEVANCE: Well-aligned fluorapatite surfaces, demonstrated to exhibit enhanced healing characteristics, will be applied to the bone- and tissue-contacting surfaces of dental implants.

描述（由申请人提供）：该I期SBIR项目的目标是证明将均匀、坚固的氟磷灰石（FA）涂层应用于牙科种植体的可行性，这将有助于控制种植体放置后的微环境。专有的涂层工艺包括在蚀刻表面上生长排列良好的氟磷灰石（FA）晶体薄膜。初步数据表明，良好的对齐FA晶体膜具有增强成骨细胞（MG-63）的粘附，增殖和矿物质形成相比，非对齐（无序）FA表面。第一阶段研究计划建议优化涂层工艺，以在钛牙科种植体上实现坚固且可重复的涂层。过程中的每一步都将经过仔细的开发和验证。将进行测试以评估FA覆盖表面的物理、化学和机械性能。当获得一致的涂层时，将测试材料的促愈合特性。 公共卫生关系：排列良好的氟磷灰石表面，表现出增强愈合的特点，将被应用于骨和组织接触表面的牙科种植体。

项目成果

In vitro differentiation and mineralization of dental pulp stem cells on enamel-like fluorapatite surfaces.

• DOI: 10.1089/ten.tec.2011.0624
• 发表时间: 2012-06
• 期刊: Tissue engineering. Part C, Methods
• 作者: Xiaodong Wang;T. Jin;Syweren Chang;Zhaocheng Zhang;A. Czajka-Jakubowska;J. Nör;B. Clarkson;L. Ni;Jun D Liu

Fluorapatite enhances mineralization of mesenchymal/endothelial cocultures.

氟磷灰石增强间充质/内皮共培养物的矿化。

• DOI: 10.1089/ten.tea.2013.0113
• 发表时间: 2014
• 期刊: Tissue engineering. Part A
• 作者: Wang,Xiaodong;Zhang,Zhaocheng;Chang,Syweren;Czajka-Jakubowska,Agata;Nör,JacquesE;Clarkson,BrianH;Ni,Longxing;Liu,Jun
• 通讯作者: Liu,Jun

VEGF promotes osteogenic differentiation of ASCs on ordered fluorapatite surfaces.

• DOI: 10.1002/jbm.a.35215
• 发表时间: 2015-02
• 期刊: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
• 影响因子: 4.9
• 作者: Clark, D.;Wang, X.;Chang, S.;Czajka-Jakubowska, A.;Clarkson, B. H.;Liu, J.
• 通讯作者: Liu, J.