Laser Capture Microdissection System

激光捕获显微切割系统

• 批准号: 7793548
• 负责人: ANDA N. CORNEA
• 金额: $ 22.27万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-20 至 2011-05-19
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793548
• 关键词: Aging; Alcoholism; Cells; Commit; Complex; Contraceptive methods; Contract Services; Development; Diabetes Mellitus; Ensure; Evaluation; Funding; Gene Expression; Health Sciences; Human Resources; Image; Infant; International; Marketing; Mental Depression; Metabolic Diseases; Morphology; Obesity; Oregon; Population; Primates; Proteins; Puberty; RNA; Research; Research Personnel; Scientist; System; Time; Tissues; Universities; Vascular Diseases; Wages; cost; instrument; laser capture microdissection; meetings; respiratory

DESCRIPTION (provided by applicant): A group of investigators at the Oregon National Primate Research Center (ONPRC) request funds to purchase a Laser Capture Microdissection System. The instrument will be used to procure pure populations of cells out of complex tissues, necessary to isolate RNA and proteins for gene expression analyses. Projects participating are making important contributions to understanding development, puberty and aging, to treating metabolic diseases, obesity and diabetes, depression, alcoholism, vascular disease, infant respiratory deficiencies, to finding new contraceptive methods. After a careful market evaluation, ArcturusXT was selected as the most versatile system, capable to meet the very diverse needs of the participating users. The new instrument will be placed in the ONPRC's Imaging and Morphology Core and will thus take advantage of the expertise and organization of a well established and supported core. ONPRC commits to ensuring long term efficient use of the instrument by covering the costs of space remodeling, service contract and personnel salary. Any instrument time not used by the projects presented here will be available to other scientists at Oregon Health & Science University, the host university, as well as to the many national and international collaborators that ONPRC traditionally hosts, thereby extending the overall benefits.

描述（由申请人提供）：俄勒冈州国家灵长类动物研究中心（ONPRC）的一组研究人员申请资金购买激光捕获显微切割系统。该仪器将用于从复杂组织中获得纯细胞群，这是分离RNA和蛋白质进行基因表达分析所必需的。参与的项目对了解发育、青春期和衰老、治疗代谢疾病、肥胖和糖尿病、抑郁症、酗酒、血管疾病、婴儿呼吸系统缺陷以及寻找新的避孕方法作出了重要贡献。经过仔细的市场评估，ArcturusXT被选为最通用的系统，能够满足参与用户的各种需求。新仪器将被放置在ONPRC的成像和形态学核心中，因此将利用成熟和支持的核心的专业知识和组织。ONPRC承诺通过支付空间改造、服务合同和人员工资的费用，确保仪器的长期有效使用。这里介绍的项目没有使用的任何仪器时间将提供给主办大学俄勒冈州健康与科学大学的其他科学家，以及ONPRC传统上主办的许多国家和国际合作者，从而扩大整体效益。