EFFECT OF MATERNAL HIGH FAT DIET ON FETAL BRAIN DEVELOPMENT

母亲高脂肪饮食对胎儿大脑发育的影响

• 批准号: 7715999
• 负责人: ANDA N. CORNEA
• 金额: $ 2.77万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2009-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7715999
• 关键词: Affect; Brain; Cardiovascular Diseases; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Diagnosis; Diet; Exposure to; Fatty acid glycerol esters; Funding; Gene Expression; Grant; Institution; Life; Maternal Exposure; Measurement; Obesity; Research; Research Personnel; Resources; Risk Factors; Source; United States National Institutes of Health; base; clinical application; diffusion anisotropy; fetal; nonhuman primate; saturated fat; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Diets rich in saturated fats, similar to common modern Western diets are known risk factors for obesity, diabetes, cardiovascular disease later in life. We investigate whether maternal exposure to a high fat diet (HFD) affects fetal brain developing in non-human primates. We correlate MRI-based diffusion anisotropy, morphological measurements and gene expression to identify causes and mechanisms of diet induced changes and set the basis for the development of a diagnosis tool for clinical applications.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 富含饱和脂肪的饮食，类似于常见的现代西方饮食，是已知的肥胖、糖尿病、心血管疾病的危险因素。 我们研究母体暴露于高脂肪饮食（HFD）是否会影响非人灵长类动物的胎儿脑发育。 我们将基于MRI的扩散各向异性、形态学测量和基因表达相关联，以确定饮食诱导变化的原因和机制，并为临床应用的诊断工具的开发奠定基础。