ADOLESCENT ANXIETY: A LONGITUDINAL TWIN STUDY PERSPECTIVE
青少年焦虑:纵向双胞胎研究的视角
基本信息
- 批准号:8076862
- 负责人:
- 金额:$ 28.31万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-01 至 2013-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescenceAdolescentAffectiveAgeAnxietyAnxiety DisordersBehaviorBehavioralBiometryBirthBirth RecordsBone callusCategoriesChildChildhoodClassificationClinicalCognitiveComorbidityDSM-IVDataDepressed moodDiagnosisDiagnosticDimensionsFamilyFoundationsFunctional Magnetic Resonance ImagingGene FamilyGeneticGenetic VariationGrowthHeritabilityHeterogeneityHydrocortisoneImageIndividualInterviewLaboratoriesLinear RegressionsMagnetic Resonance ImagingMeasuresMental DepressionMethodsModelingMothersMultivariate AnalysisNeurosecretory SystemsPatternPerformancePhenotypePregnancyProblem behaviorProcessProtocols documentationPsychopathologyQualifyingReaction TimeRisk FactorsSamplingSampling StudiesSpecific qualifier valueStressStructureSubgroupTelephone InterviewsTemperamentTestingTrier Social Stress TestTwin Multiple BirthTwin Studiesbasechildhood anxietydisease classificationfollow-uphypothalamic pituitary axisimprovedneuroimagingrelating to nervous systemsex
项目摘要
Project 3 seeks to understand the longitudinal pattern of behavioral problems in twin children by following up
a sample previously systematically ascertained from birth records. The project uses genetic latent class
analysis applied to 3-occasion, longitudinal data (age 7-8 years, 12-13 years, and 15-16 years) as a
foundation for understanding temperamental and family risk factors, as well as to provide a sample for
studying neural correlates of adolescent anxiety in Project 4. We predict that the child's standing on a profile
of seven dimensions (depressed, socially anxious, worried/obsessive, inattentive, impulsive, hyperactive,
defiant/aggressive/callous) assessed with multiple methods will reveal heterogeneity within existing DSM-IV
diagnostic categories and commonality among subgroups of children with different DSM-IV diagnoses.
Several risk factors will be examined within the context of latent growth curve analysis, including basal and
reactive cortisol patterns studied longitudinally, allelic variants of 8 genes, family stress and observed family
interaction patterns, pregnancy and birth complications, and childhood temperament.
Operationally, the project involves conducting telephone interviews of both twins and their mothers for a
sample over 1,200 twins and their mothers, extensive statistical analyses of the longitudinal data, and a
laboratory-based assessment of a subsample who qualify for a diagnosis of anxiety disorder or depression.
The laboratory-based assessment battery will include a structured psychiatric interview, cognitive/affective
assessments (reaction time and other performance-based measures), and the Trier Social Stress Test as
protocol to activate the HPA axis.
Results should improve understanding of (1) nosology of childhood anxiety problems; (2) how risk factors act
over a substantial period of childhood and adolescence; and (3) cognitive and other processes that may form
the substrate of anxious behavior.
项目3试图通过跟踪了解双胞胎儿童行为问题的纵向模式。
以前系统地从出生记录中确定的样本。该项目使用遗传潜伏期
分析适用于3次纵向数据(年龄7-8岁、12-13岁和15-16岁)
为了解气质和家庭风险因素以及为
在项目4中研究青春期焦虑的神经相关性。我们预测孩子站在侧面
七个维度(抑郁,社交焦虑,担心/强迫症,注意力不集中,冲动,多动,
挑衅性/攻击性/冷酷无情)用多种方法评估将揭示现有DSM-IV中的异质性
具有不同DSM-IV诊断的儿童亚组中的诊断类别和共性。
将在潜在增长曲线分析的范围内审查几个风险因素,包括基础和
纵向研究反应性皮质醇模式、8个基因的等位基因变异、家庭压力和观察到的家系
互动模式、妊娠和分娩并发症,以及童年气质。
在操作上,该项目包括对双胞胎和他们的母亲进行电话采访
对1200多对双胞胎和他们的母亲进行抽样,对纵向数据进行广泛的统计分析,以及
对有资格诊断为焦虑症或抑郁症的亚样本进行基于实验室的评估。
以实验室为基础的评估单元将包括结构化的精神病学面谈,认知/情感
评估(反应时间和其他基于绩效的措施),以及Trier社会压力测试AS
激活HPA轴的协议。
研究结果将提高对(1)儿童焦虑问题的病因学的理解;(2)危险因素是如何起作用的
在相当长的一段童年和青春期;以及(3)可能形成的认知和其他过程
焦虑行为的根源。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Harold Hill Goldsmith其他文献
Harold Hill Goldsmith的其他文献
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{{ truncateString('Harold Hill Goldsmith', 18)}}的其他基金
Validating RDoC for Children and Adolescents: A Twin Study with Neuroimaging
验证儿童和青少年的 RDoC:神经影像学双胞胎研究
- 批准号:
8903416 - 财政年份:2014
- 资助金额:
$ 28.31万 - 项目类别:
Validating RDoC for Children and Adolescents: A Twin Study with Neuroimaging
验证儿童和青少年的 RDoC:神经影像学双胞胎研究
- 批准号:
8689490 - 财政年份:2014
- 资助金额:
$ 28.31万 - 项目类别:
Validating RDoC for Children and Adolescents: A Twin Study with Neuroimaging
验证儿童和青少年的 RDoC:神经影像学双胞胎研究
- 批准号:
8885903 - 财政年份:2014
- 资助金额:
$ 28.31万 - 项目类别:
Validating RDoC for Children and Adolescents: A Twin Study with Neuroimaging
验证儿童和青少年的 RDoC:神经影像学双胞胎研究
- 批准号:
9301026 - 财政年份:2014
- 资助金额:
$ 28.31万 - 项目类别:
CORE-- BEHAVIORAL ASSESSMENT/CLINICAL DIAGNOSIS
核心——行为评估/临床诊断
- 批准号:
7575133 - 财政年份:2008
- 资助金额:
$ 28.31万 - 项目类别:
CORE-- BEHAVIORAL ASSESSMENT/CLINICAL DIAGNOSIS
核心——行为评估/临床诊断
- 批准号:
7357456 - 财政年份:2007
- 资助金额:
$ 28.31万 - 项目类别:
CORE-- BEHAVIORAL ASSESSMENT/CLINICAL DIAGNOSIS
核心——行为评估/临床诊断
- 批准号:
7197283 - 财政年份:2006
- 资助金额:
$ 28.31万 - 项目类别:
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