ADOLESCENT ANXIETY: A LONGITUDINAL TWIN STUDY PERSPECTIVE

青少年焦虑：纵向双胞胎研究的视角

• 批准号: 8076862
• 负责人: Harold Hill Goldsmith
• 金额: $ 28.31万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8076862
• 关键词: Adolescence; Adolescent; Affective; Age; Anxiety; Anxiety Disorders; Behavior; Behavioral; Biometry; Birth; Birth Records; Bone callus; Categories; Child; Childhood; Classification; Clinical; Cognitive; Comorbidity; DSM-IV; Data; Depressed mood; Diagnosis; Diagnostic; Dimensions; Family; Foundations; Functional Magnetic Resonance Imaging; Gene Family; Genetic; Genetic Variation; Growth; Heritability; Heterogeneity; Hydrocortisone; Image; Individual; Interview; Laboratories; Linear Regressions; Magnetic Resonance Imaging; Measures; Mental Depression; Methods; Modeling; Mothers; Multivariate Analysis; Neurosecretory Systems; Pattern; Performance; Phenotype; Pregnancy; Problem behavior; Process; Protocols documentation; Psychopathology; Qualifying; Reaction Time; Risk Factors; Sampling; Sampling Studies; Specific qualifier value; Stress; Structure; Subgroup; Telephone Interviews; Temperament; Testing; Trier Social Stress Test; Twin Multiple Birth; Twin Studies; base; childhood anxiety; disease classification; follow-up; hypothalamic pituitary axis; improved; neuroimaging; relating to nervous system; sex

Project 3 seeks to understand the longitudinal pattern of behavioral problems in twin children by following up a sample previously systematically ascertained from birth records. The project uses genetic latent class analysis applied to 3-occasion, longitudinal data (age 7-8 years, 12-13 years, and 15-16 years) as a foundation for understanding temperamental and family risk factors, as well as to provide a sample for studying neural correlates of adolescent anxiety in Project 4. We predict that the child's standing on a profile of seven dimensions (depressed, socially anxious, worried/obsessive, inattentive, impulsive, hyperactive, defiant/aggressive/callous) assessed with multiple methods will reveal heterogeneity within existing DSM-IV diagnostic categories and commonality among subgroups of children with different DSM-IV diagnoses. Several risk factors will be examined within the context of latent growth curve analysis, including basal and reactive cortisol patterns studied longitudinally, allelic variants of 8 genes, family stress and observed family interaction patterns, pregnancy and birth complications, and childhood temperament. Operationally, the project involves conducting telephone interviews of both twins and their mothers for a sample over 1,200 twins and their mothers, extensive statistical analyses of the longitudinal data, and a laboratory-based assessment of a subsample who qualify for a diagnosis of anxiety disorder or depression. The laboratory-based assessment battery will include a structured psychiatric interview, cognitive/affective assessments (reaction time and other performance-based measures), and the Trier Social Stress Test as protocol to activate the HPA axis. Results should improve understanding of (1) nosology of childhood anxiety problems; (2) how risk factors act over a substantial period of childhood and adolescence; and (3) cognitive and other processes that may form the substrate of anxious behavior.

项目3旨在通过跟踪了解双胞胎儿童行为问题的纵向模式 先前根据出生记录系统确定的样本。该项目使用遗传潜在类别 分析应用于 3 个场合的纵向数据（年龄 7-8 岁、12-13 岁和 15-16 岁） 为理解气质和家庭风险因素奠定基础，并为 研究项目 4 中青少年焦虑的神经相关性。我们预测孩子的站立情况 七个维度（抑郁、社交焦虑、担心/强迫、注意力不集中、冲动、多动、 通过多种方法评估的挑衅性/攻击性/冷酷无情）将揭示现有 DSM-IV 中的异质性 具有不同 DSM-IV 诊断的儿童亚组的诊断类别和共性。 将在潜在生长曲线分析的背景下检查几个风险因素，包括基础和 纵向研究的反应性皮质醇模式、8 个基因的等位基因变异、家庭压力和观察到的家庭 互动模式、怀孕和分娩并发症以及儿童气质。 在操作上，该项目包括对双胞胎及其母亲进行电话采访，以了解更多信息。 对 1,200 多对双胞胎及其母亲进行了抽样调查，对纵向数据进行了广泛的统计分析，并 对有资格诊断焦虑症或抑郁症的子样本进行实验室评估。 基于实验室的评估将包括结构化的精神病学访谈、认知/情感 评估（反应时间和其他基于表现的衡量标准），以及特里尔社会压力测试 激活 HPA 轴的协议。 结果应增进对（1）儿童焦虑问题的疾病分类学的理解； (2) 风险因素如何发挥作用 在童年和青春期的相当长一段时间内； (3) 可能形成的认知过程和其他过程 焦虑行为的基础。