Validating RDoC for Children and Adolescents: A Twin Study with Neuroimaging

验证儿童和青少年的 RDoC：神经影像学双胞胎研究

• 批准号: 8689490
• 负责人: Harold Hill Goldsmith
• 金额: $ 59.6万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-14 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8689490
• 关键词: 14 year old; 18 year old; 7 year old; Accounting; Acute; Address; Adolescent; Adult; Affect; Affective; Age; Amygdaloid structure; Anterior; Anxiety; Area; Behavior assessment; Behavioral; Biometry; Birth Records; Brain; Child; Child Behavior; Childhood; Corpus striatum structure; Data; Data Collection; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Dimensions; Fright; Functional Magnetic Resonance Imaging; Gender; Genetic; Hydrocortisone; Image; Impairment; Incentives; Individual; Individual Differences; Individuality; Magnetic Resonance Imaging; Maps; Measurement; Measures; Mental Health; Methods; Modality; Nature; Neurobehavioral Manifestations; Participant; Pattern; Physiology; Psychophysiology; Puberty; Quantitative Genetics; Recovery; Recovery of Function; Research Domain Criteria; Rest; Rewards; Sampling; Specific qualifier value; Spin Labels; Stimulus; Stress; Subgroup; Symptoms; System; Testing; Time; Toddler; Twin Multiple Birth; Twin Studies; Variant; Videotape; base; behavior measurement; clinically relevant; design; emotion regulation; follow-up; neural circuit; neurodevelopment; neuroimaging; neuropsychological; public health relevance; relating to nervous system; response; reward circuitry; self reported behavior; sex; stability testing

DESCRIPTION (provided by applicant): This application proposes a two-part approach to understanding developmental aspects of the RDoC positive and negative valence systems. The project focuses on objective behavioral assessment and multimodal neuroimaging. Study 1 takes advantage of 1404 children (702 twin pairs) previously objectively assessed as 7 year-olds on positive and negative affect with a battery of videotaped behavioral measures that map onto RDoC dimensions. These children had also been assessed as toddlers and were later assessed at mean age 14 years, which allows for longitudinal tests of construct validity of the RDoC systems as applied to children. Study 1 includes completion of the age 14 data collection. Study 2 proposes to follow-up, at mean age 18 years, 640 of these participants (320 same-sex twin pairs) with comprehensive neuroimaging and concurrent psychophysiological and neuropsychological measures that assess selected RDoC constructs from the positive and negative valence systems. We will determine whether standing on the childhood RDoC measures (from Study 1) predicts adolescent neuroimaging measures of reactivity and recovery of positive and negative affect (from Study 2). We will test predictions concerning correlates of standing on RDoC constructs using structural and functional connectivity and dynamic features (reactivity and recovery) of responses to affective stimuli in an automatic emotion regulation task. We use the twin design to discern whether individual differences are genetically conditioned and whether the covariance across time (stability of RDoC) and the covariance between behavioral and neural measures (neural underpinnings of RDoC) have genetic bases. We investigate environmental bases of RDoC constructs by predicting monozygotic intrapair differences in neuroimaging parameters from earlier intrapair behavioral RDoC differences and from earlier measures of adversity and stress.

描述（由申请人提供）：本申请提出了一个两部分的方法来理解RDoC正负价系统的发展方面。该项目侧重于客观行为评估和多模态神经成像。研究1利用了1404名儿童（702对双胞胎），这些儿童在7岁时被客观地评估了积极和消极的影响，并通过一系列录像的行为测量来映射到RDoC维度。这些儿童也在蹒跚学步时被评估，后来在平均14岁时被评估，这允许对RDoC系统应用于儿童的结构效度进行纵向测试。研究1包括完成14岁的数据收集。研究2建议对平均年龄为18岁的640名参与者（320对同性双胞胎）进行全面的神经影像学和同时进行的心理生理和神经心理学测量，以评估从正效价和负效价系统中选择的RDoC结构。我们将确定是否站在儿童RDoC测量（来自研究1）上预测青少年神经影像学测量的反应性和积极和消极影响的恢复（来自研究2）。我们将使用自动情绪调节任务中对情感刺激的反应的结构和功能连通性以及动态特征（反应性和恢复）来测试关于站立在RDoC结构上的相关性的预测。我们使用双胞胎设计来辨别个体差异是否受遗传制约，以及跨时间的协方差（RDoC的稳定性）以及行为和神经测量之间的协方差（RDoC的神经基础）是否具有遗传基础。我们研究了RDoC构建的环境基础，从早期的配对内行为RDoC差异和早期的逆境和压力测量中预测单卵配对内神经成像参数的差异。