Nervous System Development and Injury

神经系统发育和损伤

• 批准号: 8073060
• 负责人: DAVID M. HOLTZMAN
• 金额: $ 21.08万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1982
• 资助国家: 美国
• 起止时间: 1982-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8073060
• 关键词: Injury; nervous system development

DESCRIPTION (provided by applicant): The present application seeks continued funding for a training program at Washington University Medical School that has been jointly administered by the Departments of Neurology and Neurological Surgery for the past 24 years. The theme of the research carried out by the trainees and faculty of this grant is translational research in nervous system injury and degeneration. The primary applicant pool for the four slots requested are MD or MD/PhD residents in adult neurology, pediatric neurology, and neurosurgery at this institution. A limited number of Ph.D. candidates carrying out research consistent with the theme in the laboratories of the faculty members will also be considered, as will residents from other neuroscience-related clinical departments or residents from other institutions that seek training with our faculty. The faculty of 37 is composed of well-funded members of several clinical and basic science departments, most of whom have extensive experience in training young scientists and physician scientists. It is expected that trainees supported by this grant will carry out laboratory-based and/or clinically-based translational research for a minimum of two years as this is the minimum period necessary to develop the scientifically-trained neurological or neurosurgical clinician scientists needed to advance our understanding of the pathogenesis and treatment of these neurological disorders. In addition to the mentored research projects, trainees will participate, depending upon interests and experience, in individually designed didactic (courses, workshops, journal clubs) programs to develop needed background, specialized technical skills, and communication skills in preparation for an independent research career. All trainees will also receive training in the ethical conduct of research appropriate their experience and scientific interest (e.g., clinical- versus laboratory-based research). Procedures are described to select, evaluate, and counsel trainees. We have enjoyed reasonable success in identifying excellent minority participants in the program (15-20% of our trainees over the last 10 years) and efforts to further strengthen this aspect of our program are described. This program has, and will continue to, build upon the long tradition of excellent basic and clinical neuroscience at Washington University toward the objective of training the next generation of clinician scientists dedicated to understanding and treating these devastating disorders of the nervous system.

描述（由申请人提供）：本申请为华盛顿大学医学院的一个培训项目寻求持续的资助，该项目在过去的24年里一直由神经内科和神经外科联合管理。该基金的受训者和教师开展的研究主题是神经系统损伤和退化的转化研究。申请这四个名额的主要申请人是该机构成人神经病学、儿科神经病学和神经外科的医学博士或医学博士/博士住院医师。有限数量的博士候选人在教师实验室进行与主题一致的研究也将被考虑，其他神经科学相关临床部门的住院医生或其他机构的住院医生寻求与我们的教师一起培训。37名教师由来自几个临床和基础科学系的资金雄厚的成员组成，其中大多数人在培养年轻科学家和内科科学家方面具有丰富的经验。预计受资助的受训者将进行至少两年的实验室和/或临床转化研究，因为这是培养经过科学训练的神经或神经外科临床医生科学家所需的最短时间，以促进我们对这些神经疾病的发病机制和治疗的理解。除了受指导的研究项目外，学员还将根据兴趣和经验，参加个人设计的教学（课程、研讨会、期刊俱乐部）项目，以培养必要的背景、专业技术技能和沟通技巧，为独立的研究生涯做准备。所有受训者还将根据他们的经验和科学兴趣（例如，临床与实验室研究）接受道德研究行为方面的培训。程序描述了选择，评估和咨询学员。我们在甄别优秀的少数族裔学员方面取得了一定的成功（过去10年占我们学员的15-20%），并描述了进一步加强我们项目这方面的努力。这个项目已经并将继续建立在华盛顿大学优秀的基础和临床神经科学的悠久传统之上，以培养下一代临床科学家，致力于理解和治疗这些毁灭性的神经系统疾病。