Environmental Factors in Cardiovascular Disease

描述（由申请人提供） 这个拟议的职业中期调查员奖的目标是扩大华盛顿大学以环境健康科学为重点的多学科研究的培训。通过与几个正在进行的培训项目的合作，候选人，乔尔D。考夫曼，医学博士，公共卫生硕士，将扩大广泛的研究计划和指导计划与学员从几个相关学科。在最初的K24奖期间，考夫曼博士的研究生产力和指导增加，并加快了深度和广度。这个持续的项目将整合实验，流行病学和转化方法，以研究环境因素在心血管疾病中的作用。拟议中的研究是考夫曼博士正在进行的研究计划中两个主题相关项目的结合。这两项研究都提出了这样一个论点，即与交通有关的空气污染通过对血管系统的急性和慢性影响对心血管疾病产生影响。其中一个项目研究柴油机废气吸入对血管功能的影响，在控制暴露，解决机制假说，以了解氧化应激的作用。第二个项目基于空气污染对心血管疾病影响的流行病学研究，并在多种族人群队列中研究急性和慢性污染暴露对血管功能，动脉粥样硬化和表观基因组标记物的联合和独立影响。导师计划建立在考夫曼博士在多学科研究方面的成功基础上，旨在为来自各种学科的学员提供以患者为导向的环境健康科学研究方面的研究导师。其中包括职业和环境医学、心脏病学和肺病学研究员;医学生;以及流行病学、毒理学、职业和环境卫生、生物统计学和环境工程学研究生。该计划将包括研究基础设施（研究援助，数据分析和生物统计学）和监督研究导师。华盛顿大学为环境健康科学的合作培训和以患者为导向的研究提供了出色的环境。 公共卫生相关性：该建议旨在提供关键信息，以减少交通相关空气污染对心血管疾病发病率和患病率的公共卫生影响。通过发展和继续一个多学科的研究团队，并培训初级研究人员在人口为基础的临床/转化研究，这些活动的目的是开发相关的临床实践和公共政策的新信息。

DESCRIPTION (provided by applicant) The goal of this proposed midcareer investigator award is to expand training in multi- disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will extend a broad research program and mentoring program with trainees from several relevant disciplines. During the initial K24 award period, Dr. Kaufman's research productivity and mentorship increased and accelerated in depth and breadth. This continuing program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a combination of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that traffic-related air pollution exerts an effect on cardiovascular diseases through acute and chronic impacts on the vascular system. One project studies the effect of diesel exhaust inhalation on vascular function in controlled exposures, addressing mechanistic hypotheses to understand the role of oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on vascular function, atherosclerosis, and epigenomic markers, in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, cardiology, and pulmonary medicine; medical students; and graduate students in epidemiology, toxicology, occupational and environmental hygiene, biostatistics, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences. Public Health Relevance: This proposal aims to provide key information to reduce the public health impact of traffic-related air pollution on cardiovascular disease incidence and prevalence. By developing and continuing a multi-disciplinary research team, and training junior investigators in population-based and clinical/translational research, these activities aim to develop new information relevant to clinical practice and public policy.