Environmental Factors in Cardiovascular Disease

描述(由申请人提供) 这个拟议的职业生涯中期调查员奖的目标是扩大华盛顿大学专注于环境健康科学的多学科研究的培训。通过与几个正在进行的培训计划的合作，候选人Joel D.Kaufman，医学博士，公共卫生硕士，将扩展一个广泛的研究计划和指导计划，包括来自几个相关学科的受训者。在最初的K24奖项期间，考夫曼博士的研究生产率和指导能力在深度和广度上都得到了提高和加速。这一持续的计划将结合实验、流行病学和转化方法，研究环境因素在心血管疾病中的作用。这项拟议的研究结合了考夫曼博士正在进行的研究计划中的两个主题相关的项目。这两篇论文都阐述了与交通相关的空气污染通过对血管系统的急性和慢性影响而对心血管疾病产生影响的论点。其中一个项目研究了柴油尾气吸入对受控暴露下血管功能的影响，解决了了解氧化应激作用的机制假说。第二个项目以空气污染对心血管疾病影响的流行病学研究为基础，在一个基于多种族人群的队列中，研究了急性和慢性污染暴露对血管功能、动脉粥样硬化和表观基因组标志物的联合和独立影响。导师计划建立在考夫曼博士在多学科研究方面的成功基础上，旨在为来自不同学科的学员提供以患者为导向的环境健康科学研究方面的研究指导。他们将包括职业和环境医学、心脏病学和肺部医学的研究员；医学生；以及流行病学、毒理学、职业和环境卫生、生物统计学和环境工程的研究生。该计划将包括研究基础设施(研究援助、数据分析和生物统计学)和监督研究指导。华盛顿大学为环境健康科学方面的协作培训和以患者为中心的研究提供了一个出色的环境。 公共健康相关性：本提案旨在提供关键信息，以减少与交通相关的空气污染对心血管疾病发病率和流行率的公共健康影响。通过发展和继续建立一个多学科研究团队，并在基于人口和临床/转化性研究方面培训初级研究人员，这些活动旨在开发与临床实践和公共政策相关的新信息。

DESCRIPTION (provided by applicant) The goal of this proposed midcareer investigator award is to expand training in multi- disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will extend a broad research program and mentoring program with trainees from several relevant disciplines. During the initial K24 award period, Dr. Kaufman's research productivity and mentorship increased and accelerated in depth and breadth. This continuing program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a combination of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that traffic-related air pollution exerts an effect on cardiovascular diseases through acute and chronic impacts on the vascular system. One project studies the effect of diesel exhaust inhalation on vascular function in controlled exposures, addressing mechanistic hypotheses to understand the role of oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on vascular function, atherosclerosis, and epigenomic markers, in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, cardiology, and pulmonary medicine; medical students; and graduate students in epidemiology, toxicology, occupational and environmental hygiene, biostatistics, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences. Public Health Relevance: This proposal aims to provide key information to reduce the public health impact of traffic-related air pollution on cardiovascular disease incidence and prevalence. By developing and continuing a multi-disciplinary research team, and training junior investigators in population-based and clinical/translational research, these activities aim to develop new information relevant to clinical practice and public policy.