Fiber-based time-lens synchronized source for coherent Raman scattering microscop

描述（由申请人提供）：该研究计划的目标是开发一种用于相干拉曼散射（CRS）显微镜的新型光纤光源。我们将开发一个基于光纤的皮秒源可调谐从800 nm到910 nm和一个全光纤时间透镜同步源在1064 nm，然后证明建议的激光系统的CRS显微镜的价值。拟议的来源基于两项主要创新：（1）大模场面积（LMA）光纤中的孤子自频移（SSFS），其使得能够产生由光纤激光器以电信波长播种的能量的波长可调谐孤子脉冲（~ 1550 nm），以及（2）时间透镜脉冲压缩和同步，其使得全光纤皮秒源能够以任意重复率与锁模激光器同步。利用为电信行业开发的高度成熟和集成的技术，我们的目标是创建一个“电信级”同步源，它真正强大和交钥匙，并专门为生物医学研究和临床诊断量身定制。该项目的成功完成将促进CRS成像在生物医学研究中的广泛应用。 公共卫生相关性（由申请人提供）：拟议的计划，如果成功完成，将导致一种新的，基于光纤的同步源，将对超快技术的生物医学应用产生广泛的影响。纤维配置提供了显著的实际优点，例如紧凑的占地面积、稳健的操作、较低的成本以及在临床环境中的操作安全性。这项研究计划的成功完成将使同步皮秒源广泛地提供给生物学家和医学研究人员和从业者。

DESCRIPTION (provided by applicant): The goal of this research program is to develop a novel fiber-based source for coherent Raman scattering (CRS) microscopy. We will develop a fiber-based picosecond source tunable from 800 nm to 910 nm and an all-fiber time-lens synchronized source at 1064 nm, and then demonstrate the value of the proposed laser system for CRS microscopy. The proposed source is based on two major innovations: (1) soliton self-frequency shift (SSFS) in a large mode area (LMA) fiber that enables the generation of energetic, wavelength tunable soliton pulses seeded by a fiber laser at the telecom wavelength (~ 1550 nm), and (2) time-lens pulse compression and synchronization that enables an all-fiber picosecond source to synchronize to a mode- locked laser at arbitrary repetition rate. Leveraging the highly mature and integrated techniques that have been developed for the telecommunications industry, we aim to create a "telecom grade" synchronized source that is truly robust and turn-key, and tailored specifically for biomedical research and clinical diagnostics. The successful completion of this program will facilitate the widespread applications of CRS imaging in biomedical research. PUBLIC HEALTH RELEVANCE (provided by applicant): The proposed program, if successfully completed, leads to a novel, fiber-based synchronized source that will have a broad impact on biomedical applications of ultrafast technologies. There are significant practical advantages offered by the fiber configuration, such as compact foot print, robust operation, lower cost, and operational safety in a clinical environment. The successful completion of this research program will make synchronized picosecond sources widely accessible to biologists and medical researchers and practitioner.