Fiber-based time-lens synchronized source for coherent Raman scattering microscop

描述(由申请人提供)：该研究计划的目标是开发一种用于相干拉曼散射(CRS)显微镜的新型光纤光源。我们将开发一个从800 nm到910 nm可调谐的光纤皮秒光源和一个1064 nm的全光纤时间透镜同步光源，并展示所提出的激光系统在CRS显微镜中的应用价值。提出的光源基于两个主要创新：(1)大模面积(LMA)光纤中的孤子自频移(SSFS)，它能够在电信波长(~1550 nm)由光纤激光器种子产生能量高、波长可调的孤子脉冲；(2)时间透镜脉冲压缩和同步，使得全光纤皮秒光源能够以任意重复频率与锁模激光器同步。利用为电信行业开发的高度成熟和集成的技术，我们的目标是创建一个真正强大和交钥匙的“电信级”同步源，并专门为生物医学研究和临床诊断量身定做。该项目的成功完成将促进CRS成像在生物医学研究中的广泛应用。 公共卫生相关性(由申请者提供)：拟议的计划如果成功完成，将产生一种基于光纤的新型同步源，将对超快技术的生物医学应用产生广泛影响。光纤配置提供了显著的实用优势，如紧凑的占地面积、坚固的操作、较低的成本和临床环境下的操作安全性。这项研究计划的成功完成将使生物学家、医学研究人员和从业者能够更广泛地获取同步皮秒源。

DESCRIPTION (provided by applicant): The goal of this research program is to develop a novel fiber-based source for coherent Raman scattering (CRS) microscopy. We will develop a fiber-based picosecond source tunable from 800 nm to 910 nm and an all-fiber time-lens synchronized source at 1064 nm, and then demonstrate the value of the proposed laser system for CRS microscopy. The proposed source is based on two major innovations: (1) soliton self-frequency shift (SSFS) in a large mode area (LMA) fiber that enables the generation of energetic, wavelength tunable soliton pulses seeded by a fiber laser at the telecom wavelength (~ 1550 nm), and (2) time-lens pulse compression and synchronization that enables an all-fiber picosecond source to synchronize to a mode- locked laser at arbitrary repetition rate. Leveraging the highly mature and integrated techniques that have been developed for the telecommunications industry, we aim to create a "telecom grade" synchronized source that is truly robust and turn-key, and tailored specifically for biomedical research and clinical diagnostics. The successful completion of this program will facilitate the widespread applications of CRS imaging in biomedical research. PUBLIC HEALTH RELEVANCE (provided by applicant): The proposed program, if successfully completed, leads to a novel, fiber-based synchronized source that will have a broad impact on biomedical applications of ultrafast technologies. There are significant practical advantages offered by the fiber configuration, such as compact foot print, robust operation, lower cost, and operational safety in a clinical environment. The successful completion of this research program will make synchronized picosecond sources widely accessible to biologists and medical researchers and practitioner.