Fiber-based time-lens synchronized source for coherent Raman scattering microscop

描述（由申请人提供）：本研究项目的目标是开发一种新的基于光纤的相干拉曼散射（CRS）显微镜光源。我们将开发800 ~ 910 nm的光纤皮秒源和1064 nm的全光纤时透镜同步源，然后证明所提出的激光系统在CRS显微镜中的价值。提出的光源基于两个主要创新：(1)大模区（LMA）光纤中的孤子自频移（SSFS），使光纤激光器能够在电信波长（~ 1550 nm）产生能量，波长可调的孤子脉冲；(2)时间透镜脉冲压缩和同步，使全光纤皮秒源能够以任意重复率同步到锁模激光器。利用为电信行业开发的高度成熟和集成的技术，我们的目标是创建一个真正强大和交钥匙的“电信级”同步源，专门为生物医学研究和临床诊断量身定制。该项目的成功完成将促进CRS成像在生物医学研究中的广泛应用。

DESCRIPTION (provided by applicant): The goal of this research program is to develop a novel fiber-based source for coherent Raman scattering (CRS) microscopy. We will develop a fiber-based picosecond source tunable from 800 nm to 910 nm and an all-fiber time-lens synchronized source at 1064 nm, and then demonstrate the value of the proposed laser system for CRS microscopy. The proposed source is based on two major innovations: (1) soliton self-frequency shift (SSFS) in a large mode area (LMA) fiber that enables the generation of energetic, wavelength tunable soliton pulses seeded by a fiber laser at the telecom wavelength (~ 1550 nm), and (2) time-lens pulse compression and synchronization that enables an all-fiber picosecond source to synchronize to a mode- locked laser at arbitrary repetition rate. Leveraging the highly mature and integrated techniques that have been developed for the telecommunications industry, we aim to create a "telecom grade" synchronized source that is truly robust and turn-key, and tailored specifically for biomedical research and clinical diagnostics. The successful completion of this program will facilitate the widespread applications of CRS imaging in biomedical research. PUBLIC HEALTH RELEVANCE (provided by applicant): The proposed program, if successfully completed, leads to a novel, fiber-based synchronized source that will have a broad impact on biomedical applications of ultrafast technologies. There are significant practical advantages offered by the fiber configuration, such as compact foot print, robust operation, lower cost, and operational safety in a clinical environment. The successful completion of this research program will make synchronized picosecond sources widely accessible to biologists and medical researchers and practitioner.