Role of fronto-parietal cortices in the prediction of self-generated and observed

额顶叶皮层在预测自身生成和观察到的信息中的作用

• 批准号: 8011950
• 负责人: SCOTT Thomas GRAFTON
• 金额: $ 2.99万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA BARBARA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-02-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8011950
• 关键词: Affect; Algorithms; Area; Argentina; Ataxia; Autistic Disorder; Basal Ganglia; Behavior; Brain Mapping; Brain region; Cerebellum; Child; Code; Cognitive; Collaborations; Computers; Cues; Development; Devices; Disease; Dorsal; Environment; Feedback; Forearm; Functional Magnetic Resonance Imaging; Future; Generations; Gestures; Goals; Grant; Health; Human; Ideomotor Apraxia; Intention; Learning; Link; Mechanics; Modeling; Modification; Motor; Motor Cortex; Movement; Muscle; Musculoskeletal; Nervous System Trauma; Nervous system structure; Neurons; Noise; Optics; Outcome; Paralysed; Parents; Parietal; Parietal Lobe; Patients; Perception; Physiology; Positioning Attribute; Prefrontal Cortex; Preparation; Principal Investigator; Process; Production; Proprioception; Prosthesis; Relative (related person); Research; Research Personnel; Research Project Grants; Resistance; Resolution; Role; Rotation; Schizophrenia; Sensory; Short-Term Memory; Signal Transduction; System; Techniques; Testing; Time; Training; Transcranial magnetic stimulation; United States National Institutes of Health; Universities; Update; Vision; Visual; arm; base; blood oxygen level dependent; design; medical schools; motor control; neurophysiology; parent grant; programs; rehearsal; relating to nervous system; research study; response; sensory feedback; skills; social; visual feedback; visual information; visual motor

DESCRIPTION (provided by applicant): This grant will be done primarily in Argentina at the Department of Physiology, School of Medicine, University of Buenos Aires in collaboration with Valeria Della-Maggiore, as an extension of NIH Grant No. P01 NS044393. Our daily routine involves acting on objects in our vicinity to achieve different goals. Sudden, unpredictable modifications in the environment require immediate adjustment of these well-practiced movements by updating the initial motor plan online, while persistent perturbations can be adapted to through learning over a longer time scale. Both types of adjustments may partly rely on the nervous system's ability to predict the future state of the motor system. An intriguing possibility is that the same mechanism necessary to adjust skilled behavior may be used at a higher cognitive level to predict the outcome of actions performed by others. This phenomenon, known as action observation, may be the basis to understanding other people's actions and learning by imitation. The present research project is aimed at identifying the neural substrates of motor prediction in humans and evaluating its contribution to the production and perception of action. These issues will be approached experimentally using transcranial magnetic stimulation and functional magnetic resonance imaging to characterize the role and timing of dorsal premotor and posterior parietal cortices in the prediction of action during: 1) the online adjustment of movement; 2) visuomotor learning; 3) observation of actions performed by others. PUBLIC HEALTH RELEVANCE: A better understanding of the role of posterior parietal and dorsal premotor cortices during production and perception of action will be informative at many levels. It may provide clues to the mechanism by which children learn social cues from observing and predicting the actions of others and how or why such learning goes awry in disorders such as autism or schizophrenia. It is also relevant for understanding the deficits of patients with neurological damage affecting the processing of visuomotor transformations such as optic ataxia (deficit in accurately reaching to objects) and ideomotor apraxia (deficit in imitating gestures under command) and, thus, may guide the development of the appropriate therapy to treat these patients. Finally, due to their role in movement preparation and movement intention, the PMd and PPC appear as suitable brain regions for the control of human prosthetics. These devices are aimed at aiding paralyzed patients interact with their environment. Neurophysiological activity of the PPC or PMd, could be decoded into signals to activate stimulators imbedded in the muscles of a patient, initiate the movement of a prosthetic arm or operate external devices such as a computer (Andersen et al., 2004; Musallam et al., 2004,Bokil et. al., 2006). Knowing the time course of PPC and PMd processing may help guide the interpretation of neuronal signals during the redirection of movement intention, and train adaptive algorithms to predict the goal and consequences of other people's actions solely based on neuronal activity elicited during action rehearsal.

描述（由申请人提供）：该资助将主要在阿根廷布宜诺斯艾利斯大学医学院生理学系与Valeria Della-Maggiore合作完成，作为NIH资助号P01 NS 044393的扩展。我们的日常工作包括对我们附近的物体采取行动，以实现不同的目标。环境中突然的、不可预测的变化需要通过在线更新初始运动计划来立即调整这些熟练的动作，而持续的扰动可以通过在更长时间范围内学习来适应。这两种类型的调整都可能部分依赖于神经系统预测运动系统未来状态的能力。一个有趣的可能性是，在更高的认知水平上，调整熟练行为所必需的机制也可以用来预测他人行为的结果。这种现象被称为动作观察，可能是理解他人动作和模仿学习的基础。本研究项目旨在确定人类运动预测的神经基质，并评估其对动作产生和感知的贡献。这些问题将采用经颅磁刺激和功能性磁共振成像进行实验，以表征背侧运动前区和后顶叶皮质在以下过程中预测动作的作用和时间：1）在线调整运动; 2）视觉学习; 3）观察他人执行的动作。公共卫生相关性：更好地理解后顶叶和背侧运动前皮质在动作产生和感知过程中的作用将在许多层面上提供信息。它可能为儿童通过观察和预测他人的行为来学习社会线索的机制提供线索，以及这种学习如何或为什么会在自闭症或精神分裂症等疾病中出错。这也是相关的理解与神经损伤的患者影响视觉转换的处理，如视共济失调（赤字准确地达到的对象）和idetranitisapraxia（赤字在模仿手势下的命令）的缺陷，因此，可能会指导开发适当的治疗方法来治疗这些患者。最后，由于它们在运动准备和运动意图中的作用，PMd和PPC似乎是用于控制人类假肢的合适的大脑区域。这些设备旨在帮助瘫痪患者与他们的环境互动。PPC或PMd的神经生理学活动可以被解码成信号以激活嵌入患者肌肉中的刺激器，启动假肢的运动或操作外部设备如计算机（Andersen等人，2004; Musallam等人，2004年，博伊莱特。例如，2006年）。了解PPC和PMd处理的时间过程可能有助于在运动意图的重定向期间指导神经元信号的解释，并训练自适应算法，以仅基于动作排练期间引起的神经元活动来预测其他人动作的目标和后果。

项目成果

FMRI supports the sensorimotor theory of motor resonance.

• DOI: 10.1371/journal.pone.0026859
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Landmann C;Landi SM;Grafton ST;Della-Maggiore V
• 通讯作者: Della-Maggiore V

Extinction interferes with the retrieval of visuomotor memories through a mechanism involving the sensorimotor cortex.

消退通过涉及感觉运动皮层的机​​制干扰视觉运动记忆的检索。

• DOI: 10.1093/cercor/bht346
• 发表时间: 2015
• 期刊: Cerebral cortex (New York, N.Y. : 1991)
• 作者: Villalta,JorgeI;Landi,SofiaM;Fló,Ana;Della-Maggiore,Valeria
• 通讯作者: Della-Maggiore,Valeria

One week of motor adaptation induces structural changes in primary motor cortex that predict long-term memory one year later.

• DOI: 10.1523/jneurosci.2253-11.2011
• 发表时间: 2011-08-17
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Landi SM;Baguear F;Della-Maggiore V
• 通讯作者: Della-Maggiore V