Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression

白藜芦醇、碳水化合物限制与前列腺癌进展

• 批准号: 8115766
• 负责人: Stephen Jay Freedland
• 金额: $ 30.05万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8115766
• 关键词: Accounting; Androgens; Animals; Apoptosis; Body Weight; Carbohydrates; Caring; Cessation of life; Clinical Research; Clinical Trials; Complementary Medicine; Data; Development; Diet; Diet Modification; Dietary Fats; Dose; Epidemiology; Fat-Restricted Diet; Fatty acid glycerol esters; Foundations; Future; Goals; Growth; Human; Hyperphagia; In Vitro; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Intake; Laboratories; Macronutrients Nutrition; Malignant Neoplasms; Malignant neoplasm of prostate; Morbidity - disease rate; Mus; Necrosis; Phenotype; Phytochemical; Play; Proteins; Public Health; Reducing diet; Relative (related person); Research Design; Resveratrol; Role; Signal Transduction; Solid; Somatomedins; Supplementation; Testing; Transgenic Mice; Transgenic Organisms; United States; Weight; Weight Gain; Work; Xenograft procedure; androgen independent prostate cancer; base; cancer cell; cancer therapy; cancer type; feeding; improved; in vivo; men; mortality; novel; pre-clinical; preclinical study; prevent; red wine; tumor; tumor growth; tumor progression

DESCRIPTION (provided by applicant): Diet is thought to play a major role in prostate cancer development and progression, yet little is currently known. Preliminary studies from our laboratory have demonstrated that a diet completely devoid of carbohydrates can slow in vivo prostate cancer growth and appears to act via the insulin-like growth factor (IGF) axis. Recent data from others suggests that resveratrol, a natural phytochemical found in red wine, can slow tumor growth via the same mechanism. We hypothesize that the combination of carbohydrate restriction plus resveratrol , both acting via IGF-axis inhibition, can a ct together to delay prostate cancer growth. To test this hypothesis, we will pursue the following course of study: 1) determine the amount of carbohydrate restriction needed to maximally delay prostate cancer growth; 2) eucidate the role of resveratrol in delaying prostate cancer growth and determine the dose which maximally delays tumor growth; and 3) explore the combined effects of carbohydrate restriction and resveratrol supplementation relative to treatment with a Western diet. We believe these studies will better elucidate the role of carbohydrate restriction and resveratrol in modulating in vivo prostate cancer growth and will lay the solid foundation for future preclinical studies for men with prostate cancer. PUBLIC HEALTH STATEMENT Prostate cancer is a major cause of morbidity and mortality among men in the United States. In this proposal, we aim to develop novel non-toxic complementary treatments aimed at slowing prostate cancer progression: dietary modification and phytopharmaceuticals. If these pre-clinical studies are successful, this will lay a solid foundation for future clinical studies among men with prostate cancer, which eventually stand the possibility of radically altering and improving care for men with prostate cancer.

描述（由申请人提供）： 饮食被认为在前列腺癌的发展和进展中起着重要作用，但目前知之甚少。 我们实验室的初步研究表明，完全不含碳水化合物的饮食可以减缓体内前列腺癌的生长，并且似乎通过胰岛素样生长因子（IGF）轴起作用。 最近来自其他人的数据表明，白藜芦醇，一种在红葡萄酒中发现的天然植物化学物质，可以通过相同的机制减缓肿瘤生长。我们假设限制碳水化合物摄入加上白藜芦醇，两者都通过抑制IGF轴发挥作用，可以共同延缓前列腺癌的生长。为了验证这一假设，我们将进行以下研究：1）确定最大限度地延缓前列腺癌生长所需的碳水化合物限制量; 2）确定白藜芦醇在延缓前列腺癌生长中的作用，并确定最大限度地延缓肿瘤生长的剂量; 3）探索碳水化合物限制和白藜芦醇补充剂相对于西方饮食治疗的联合作用。我们相信这些研究将更好地阐明碳水化合物限制和白藜芦醇在体内调节前列腺癌生长中的作用，并将为未来前列腺癌患者的临床前研究奠定坚实的基础。 前列腺癌是美国男性发病率和死亡率的主要原因。在这项提案中，我们的目标是开发新的无毒补充治疗方法，旨在减缓前列腺癌的进展：饮食调整和植物药物。如果这些临床前研究取得成功，这将为前列腺癌患者未来的临床研究奠定坚实的基础，最终有可能从根本上改变和改善前列腺癌患者的护理。