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Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression

白藜芦醇、碳水化合物限制与前列腺癌进展

基本信息

批准号：
7885394
负责人：
Stephen Jay Freedland
金额：
$ 30.98万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7885394
关键词：
Accounting Androgens Animals Apoptosis Body Weight Carbohydrates Caring Cessation of life Clinical Research Clinical Trials Complementary Medicine Data Development Diet Diet Modification Dietary Fats Dose Epidemiology Fat-Restricted Diet Fatty acid glycerol esters Foundations Future Goals Growth Human Hyperphagia In Vitro Insulin Insulin-Like Growth Factor Binding Protein 3 Insulin-Like Growth Factor I Intake Laboratories Macronutrients Nutrition Malignant Neoplasms Malignant neoplasm of prostate Morbidity - disease rate Mus Necrosis Phenotype Phytochemical Play Proteins Public Health Reducing diet Relative (related person)Research Design Resveratrol Role Signal Transduction Solid Somatomedins Supplementation Testing Transgenic Mice United States Weight Weight Gain Work Xenograft procedure androgen independent prostate cancer base cancer cell cancer therapy cancer type feeding improved in vivo men mortality novel pre-clinical preclinical study prevent red wine tumor tumor growth tumor progression

项目摘要

DESCRIPTION (provided by applicant): Diet is thought to play a major role in prostate cancer development and progression, yet little is currently known. Preliminary studies from our laboratory have demonstrated that a diet completely devoid of carbohydrates can slow in vivo prostate cancer growth and appears to act via the insulin-like growth factor (IGF) axis. Recent data from others suggests that resveratrol, a natural phytochemical found in red wine, can slow tumor growth via the same mechanism. We hypothesize that the combination of carbohydrate restriction plus resveratrol , both acting via IGF-axis inhibition, can a ct together to delay prostate cancer growth. To test this hypothesis, we will pursue the following course of study: 1) determine the amount of carbohydrate restriction needed to maximally delay prostate cancer growth; 2) eucidate the role of resveratrol in delaying prostate cancer growth and determine the dose which maximally delays tumor growth; and 3) explore the combined effects of carbohydrate restriction and resveratrol supplementation relative to treatment with a Western diet. We believe these studies will better elucidate the role of carbohydrate restriction and resveratrol in modulating in vivo prostate cancer growth and will lay the solid foundation for future preclinical studies for men with prostate cancer. PUBLIC HEALTH STATEMENT Prostate cancer is a major cause of morbidity and mortality among men in the United States. In this proposal, we aim to develop novel non-toxic complementary treatments aimed at slowing prostate cancer progression: dietary modification and phytopharmaceuticals. If these pre-clinical studies are successful, this will lay a solid foundation for future clinical studies among men with prostate cancer, which eventually stand the possibility of radically altering and improving care for men with prostate cancer.

描述（由申请人提供）：