Resveratrol, Carbohydrate Restriction and Prostate Cancer Progression

白藜芦醇、碳水化合物限制与前列腺癌进展

• 批准号: 8310811
• 负责人: Stephen Jay Freedland
• 金额: $ 30.05万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8310811
• 关键词: Accounting; Androgens; Animals; Apoptosis; Body Weight; Carbohydrates; Caring; Cessation of life; Clinical Research; Clinical Trials; Complementary Medicine; Data; Development; Diet; Diet Modification; Dietary Fats; Dose; Epidemiology; Fat-Restricted Diet; Fatty acid glycerol esters; Foundations; Future; Goals; Growth; Health; Human; Hyperphagia; In Vitro; Insulin; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Intake; Macronutrients Nutrition; Malignant Neoplasms; Malignant neoplasm of prostate; Morbidity - disease rate; Mus; Necrosis; Phenotype; Phytochemical; Proteins; Public Health; Reducing diet; Relative (related person); Research Design; Resveratrol; Role; Signal Transduction; Solid; Somatomedins; Testing; Transgenic Mice; Transgenic Organisms; United States; Weight; Weight Gain; Work; Xenograft procedure; androgen independent prostate cancer; base; cancer cell; cancer therapy; cancer type; feeding; improved; in vivo; men; mortality; novel; pre-clinical; preclinical study; prevent; tumor; tumor progression

PUBLIC HEALTH STATEMENT Prostate cancer is a major cause of morbidity and mortality among men in the United States. In this proposal, we aim to develop novel non-toxic complementary treatments aimed at slowing prostate cancer progression: dietary modification and phytopharmaceuticals. If these pre-clinical studies are successful, this will lay a solid foundation for future clinical studies among men with prostate cancer, which eventually stand the possibility of radically altering and improving care for men with prostate cancer.

公共卫生声明 前列腺癌是美国男性发病和死亡的主要原因。在这个 提议，我们的目标是开发旨在减缓前列腺癌的新型无毒补充疗法 进展：饮食调整和植物药物。如果这些临床前研究成功的话 将为未来男性前列腺癌临床研究奠定坚实的基础，该研究最终站得住脚 从根本上改变和改善对患有前列腺癌的男性的护理的可能性。

项目成果

Racial differences in adipose tissue distribution and risk of aggressive prostate cancer among men undergoing radiotherapy.

• DOI: 10.1158/1055-9965.epi-14-0236
• 发表时间: 2014-11
• 期刊: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
• 作者: Allott EH;Howard LE;Song HJ;Sourbeer KN;Koontz BF;Salama JK;Freedland SJ
• 通讯作者: Freedland SJ

Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.

• DOI: 10.1111/bju.12720
• 发表时间: 2014-11
• 期刊: BJU international
• 影响因子: 4.5
• 作者: Allott EH;Howard LE;Cooperberg MR;Kane CJ;Aronson WJ;Terris MK;Amling CL;Freedland SJ
• 通讯作者: Freedland SJ

Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma.

• DOI: 10.1097/cmr.0b013e3283426805
• 发表时间: 2011-02
• 期刊: Melanoma research
• 影响因子: 2.2
• 作者: de Ridder GG;Gonzalez-Gronow M;Ray R;Pizzo SV
• 通讯作者: Pizzo SV

Low-Carbohydrate Diets and Prostate Cancer: How Low Is "Low Enough"?

• DOI: 10.1158/1940-6207.capr-10-0071
• 发表时间: 2010-09-01
• 期刊: CANCER PREVENTION RESEARCH
• 影响因子: 3.3
• 作者: Masko, Elizabeth M.;Thomas, Jean A., II;Freedland, Stephen J.
• 通讯作者: Freedland, Stephen J.

Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer.

• DOI: 10.1111/j.1464-410x.2012.10971.x
• 发表时间: 2012-10
• 期刊: BJU international
• 影响因子: 4.5
• 作者: Kim HS;Masko EM;Poulton SL;Kennedy KM;Pizzo SV;Dewhirst MW;Freedland SJ
• 通讯作者: Freedland SJ