ESTABLISHMENT OF SPECIFIC PATHOGEN FREE RHESUS AND PIGTA: AIDS ANIMAL MODEL

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 描述(由申请人提供)：机会性人类病毒和它们的猿猴病毒在基因构成上相似，并在其免疫抑制的宿主中引发类似的疾病谱。恒河猴实验性慢病毒感染被广泛认为是艾滋病相关研究中最重要的动物模型，迫切需要扩大育种计划，以满足未来艾滋病疫苗和发病机制研究计划的需要。建议开发一个不含机会性病毒剂的印度恒河猴繁殖群体，以加强这一独特资源对艾滋病相关机会性感染研究的有用性。建议为这一独特的无特定病原体(ESPF)猕猴资源提供一个受保护的空间，并促进加强猕猴繁殖工作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): Opportunistic human viruses and their simian counterparts are similar in their genetic makeup and induce a similar spectrum of diseases in their immunosuppressed hosts. Experimental lentivirus infections in rhesus macaques are wildly recognized as the most import animal model for AIDS-related research and there is an urgent need to expand breeding programs to meet future AIDS vaccine and pathogenesis research program needs. Development of an Indian rhesus macaque breeding colony free of opportunistic viral agents is proposed to enhance the usefulness of this unique resource for studies focused on AIDS-related opportunistic infections. Housing space is proposed to provide a protected environment for this unique Expanded Specific Pathogen Free (ESPF) macaque resource and to facilitate enhanced macaque breeding efforts.