Clinical and Translational Science Institute at Children's National

国家儿童医院临床与转化科学研究所

基本信息

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Joseph, JIN G. After a decade of remarkable research growth and institutional investment. Children's National Medical Center (CNMC) builds on significant strategic recruitments, reorganizations, and collaborations required to create the transformative capabilities of the Clinical and Translational Science Institute at Children's National (CTSI-CN). It has done so in partnership with its academic affiliate, the George Washington University. The specific objectives of our application are to: 1) Provide state-of-the-art, flexible resources required by CTR investigators; 2) Promote multidisciplinary clinical and translational research (CTR); 3) Strengthen CTR education and training for diverse trainees at all stages of career development; 4) Promote demographic diversity and address health disparities; 5) Incorporate effective and sustained collaboration with community partners; 6) Assure efficiency of CTR from conceptualization through dissemination; and 7) Establish bi-directional collaborations with the CTSA network. The CTSI-CN has innovative features including: a child health focus, especially emphasizing health disparities and childhood antecedents of adult diseases; our relationship with a national network of 1200 community health centers, and in Tl strengths in rare diseases and neurodevelopmental disabilities. We have combined certain related CTSA components to provide more closely integrated, investigator-focused capabilities. Biomedical Informatics (Bl): provides the backbone informatics support to all CTSI-CN components. Research Education, Training and Career Development (RETCD) integrates, supports, and expands CTR education and training so that it is available from high school through mid-career. A new degree program (MS in CTR) and a certificate program are complemented by diverse educational opportunities for faculty, trainees, and staff at all levels of experience. Specialized programs are available for mid-level faculty to promote their career advancement and mentoring capabilities, and for underrepresented minority undergraduates potentially interested in a career in CTR. Community Engagement and Research/Health Policy (CER/HP) integrates traditional community engagement/research with nationally recognized health policy capabilities. Participant and Clinical Interactions Resources (PCIR) transforms our existing GCRC into a nimble and innovative resource that supports participant interactions at diverse locations including CNMC, outpatient facilities, GW, and the community. Pilot and Collaborative Translational and Clinical Studies: supports transfomnative ideas by investigators at all career levels. Novel Clinical and Translational Methodologies (NCTM) identifies needs and gaps and supports development of innovative methodologies, especially to support TTR cores. Research Design. Epidemiology. Biostatistics, and Clinical Research Ethics/Regulatory Knowledge and Support (DBE/RKS): provides integrated, investigator-focused resources to assure the quality of research and the protection of human subjects at all stages of research. Translational Technologies and Resources (TTR) supports a diverse group of 15 core functions. Tracking and Evaluation (TE): CTSI-CN activities will be guided and modified by a thoughtful and detailed evaluation plan. RELEVANCE (See instructions): The CTSI-CN provides highly integrated, cost effective, investigator-focused resources designed to overcome obstacles to investigation, promote collaborative research, and be continuously monitored and evaluated to identify when further adaptation or modification is needed. Located in the nation's capital and serving a population of children and families disproportionately affected by health disparities, the CTSI-CN brings to bear unique resources in translating discovery to improved health, particularly in our most disadvantaged populations of children.
项目负责人/主要研究者(最后,第一,中间):Joseph,JIN G。 经过十年的显著研究增长和机构投资。全国儿童医疗中心 (CNMC)建立在重要的战略招聘,重组和合作,以创建 儿童国家临床和转化科学研究所(CTSI-CN)的变革能力。 它是与其学术分支机构乔治华盛顿大学合作开展这项工作的。具体 我们申请的目的是:1)提供CTR调查人员所需的最先进、灵活的资源; 2)促进多学科临床和转化研究(CTR); 3)加强CTR教育, 在职业发展的各个阶段为不同的受训人员提供培训; 4)促进人口的多样性, 健康差距; 5)与社区合作伙伴进行有效和持续的合作; 6)确保 CTR从概念化到传播的效率;以及7)建立双向合作 CTSA网络。CTSI-CN具有创新的特点,包括:儿童健康重点,特别是 强调健康差距和成人疾病的童年前因;我们与国家的关系 1200个社区卫生中心的网络,以及在罕见疾病和神经发育方面的TL优势 残疾。我们结合了某些相关的CTSA组件,以提供更紧密的集成, 专注于能力。生物医学信息学(BI):为所有人提供骨干信息学支持 CTSI-CN组件。研究教育,培训和职业发展(RETCD)整合, 支持和扩大CTR教育和培训,使其从高中到职业生涯中期都可以使用。 一个新的学位课程(CTR硕士)和证书课程是由多样化的教育补充 为教师,学员和各级经验的工作人员的机会。专业课程可用于 中级教师,以促进他们的职业发展和指导能力,并为代表性不足 少数民族大学生可能对CTR的职业感兴趣。社区参与和 研究/卫生政策(CER/HP)将传统的社区参与/研究与国家 卫生政策能力。参与者和临床互动资源(PCIR)将我们的 将现有的GCRC转化为灵活的创新资源,支持不同地点的参与者互动 包括CNMC、门诊设施、GW和社区。试点和协作翻译和 临床研究:支持所有职业水平的研究者的个性化想法。新的临床和 翻译方法(NCTM)确定需求和差距,并支持开发创新的 方法,特别是支持TTR核心。研究设计。流行病学。生物统计学和临床 研究伦理/监管知识和支持(DBE/RKS):提供综合的,以监管者为中心的 确保研究质量和在研究的各个阶段保护人类受试者的资源。 翻译技术和资源(TTR)支持15个核心功能的多样化组。跟踪和 评估(TE):CTSI-CN活动将由一个深思熟虑的详细评估计划指导和修改。 相关性(参见说明): CTSI-CN提供高度集成的、具有成本效益的、以制造商为重点的资源,旨在克服 调查的障碍,促进合作研究,并不断监测和评估, 确定何时需要进一步调整或修改。位于国家首都,服务于 儿童和家庭人口不成比例地受到健康差距的影响,CTSI-CN带来了负担 将发现转化为改善健康的独特资源,特别是在我们最弱势的人群中 儿童人口。

项目成果

期刊论文数量(49)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Quantifying federal funding and scholarly output related to the academic emergency medicine consensus conferences.
Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations.
  • DOI:
    10.1186/s12920-018-0340-3
  • 发表时间:
    2018-02-27
  • 期刊:
  • 影响因子:
    2.7
  • 作者:
    Gomez JL;Diaz MP;Nino G;Britto CJ
  • 通讯作者:
    Britto CJ
Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood.
  • DOI:
    10.1371/journal.pone.0162244
  • 发表时间:
    2016
  • 期刊:
  • 影响因子:
    3.7
  • 作者:
    Gutierrez MJ;Gomez JL;Perez GF;Pancham K;Val S;Pillai DK;Giri M;Ferrante S;Freishtat R;Rose MC;Preciado D;Nino G
  • 通讯作者:
    Nino G
Semi-automatic segmentation of the placenta into fetal and maternal compartments using intravoxel incoherent motion MRI.
使用体素内不相干运动 MRI 将胎盘半自动分割为胎儿和母体区室。
A Generic Approach to Lung Field Segmentation From Chest Radiographs Using Deep Space and Shape Learning.
使用深空间和形状学习从胸部 X 线照片进行肺野分割的通用方法。
  • DOI:
    10.1109/tbme.2019.2933508
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Mansoor,Awais;Cerrolaza,JuanJ;Perez,Geovanny;Biggs,Elijah;Okada,Kazunori;Nino,Gustavo;Linguraru,MariusGeorge
  • 通讯作者:
    Linguraru,MariusGeorge
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LISA MARIE GUAY-WOODFORD其他文献

LISA MARIE GUAY-WOODFORD的其他文献

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{{ truncateString('LISA MARIE GUAY-WOODFORD', 18)}}的其他基金

UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 临床、转化和生物样本库资源
  • 批准号:
    10455719
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Decoding reno-protective mechanisms in mouse Pkhd1 models: Implications for ARPKD therapeutics
解码小鼠 Pkhd1 模型中的肾脏保护机制:对 ARPKD 治疗的影响
  • 批准号:
    10170340
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 临床、转化和生物样本库资源
  • 批准号:
    10685977
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Decoding reno-protective mechanisms in mouse Pkhd1 models: Implications for ARPKD therapeutics
解码小鼠 Pkhd1 模型中的肾脏保护机制:对 ARPKD 治疗的影响
  • 批准号:
    10382438
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
UAB Childhood Cystic Kidney Disease Core Center (UAB-CCKDCC) - Clinical, Translational, and Biorepository Resource
UAB 儿童囊性肾病核心中心 (UAB-CCKDCC) - 临床、转化和生物样本库资源
  • 批准号:
    10218162
  • 财政年份:
    2020
  • 资助金额:
    --
  • 项目类别:
Clinical and Translational Science Institute at Childrens National
国家儿童医院临床与转化科学研究所
  • 批准号:
    9534792
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
UAB CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCE (CCTS) UL1
阿拉巴马大学临床与转化科学中心 (CCTS) UL1
  • 批准号:
    8365094
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
CTSA INFRASTRUCTURE FOR CLINICAL TRIALS
CTSA 临床试验基础设施
  • 批准号:
    8365095
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCH
CTSA 儿科研究基础设施
  • 批准号:
    8365096
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:
CTSA INFRASTRUCTURE FOR AIDS RESEARCH
CTSA 艾滋病研究基础设施
  • 批准号:
    8365098
  • 财政年份:
    2011
  • 资助金额:
    --
  • 项目类别:

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为戒烟的成年电子烟使用者共同设计生活方式、戒烟干预措施(CLOVER 研究)
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问题提示表对于 25 岁以下青少年和年轻成年患者的肿瘤生育力的有用性。
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成人先天性心脏病患者过渡护理的问题识别和模型开发。
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