Clinical and Translational Science Institute at Children's National

经过十年显著的研究增长和机构投资，国家儿童医学中心（CNMC）建立了重要的战略招聘、重组和合作，以创造国家儿童临床和转化科学研究所（CTSI-CN）的变革能力。它与其学术分支机构乔治华盛顿大学（George Washington University）合作开展了这项工作。我们申请的具体目标是：1)提供CTR研究者所需的最先进、灵活的资源；2)促进多学科临床与转化研究（CTR）；3)加强对学员职业发展各个阶段的CTR教育和培训；4)促进人口多样性，解决健康差距问题；5)与社区伙伴进行有效和持续的合作；6)从概念到传播，保证点击率的效率；7)与CTSA网络建立双向合作关系。CTSI-CN具有创新特点，包括：以儿童健康为重点，特别强调健康差异和成人疾病的儿童前因；我们与全国1200个社区卫生中心的关系，以及TI在罕见疾病和神经发育障碍方面的优势。我们结合了某些相关的CTSA组件，以提供更紧密集成的、以研究人员为中心的能力。生物医学信息学（BI）：为CTSI-CN所有组件提供主干信息学支持。研究教育，培训和职业发展（RETCD）整合，支持和扩展CTR教育和培训，以便从高中到职业中期都可以使用。新的学位课程（CTR硕士）和证书课程为教师、学员和各级经验的员工提供了多样化的教育机会。专门的课程可以为中级教师提供，以促进他们的职业发展和指导能力，以及对CTR职业感兴趣的少数族裔本科生。社区参与和研究/卫生政策（CER/HP）将传统的社区参与/研究与国家认可的卫生政策能力相结合。参与者和临床互动资源（PCIR）将我们现有的GCRC转变为一个灵活和创新的资源，支持不同地点的参与者互动，包括CNMC，门诊设施，GW和社区。试点和协作转化和临床研究：支持所有职业水平的研究人员的变革思想。新型临床和转化方法（NCTM）确定需求和差距，并支持创新方法的发展，特别是支持TTR核心。研究设计。流行病学、生物统计学和临床研究伦理/监管知识和支持（DBE/RKS）：提供综合的、以研究者为中心的资源，以确保研究质量，并在研究的各个阶段保护人类受试者。翻译技术和资源（TTR）支持15个核心功能的多样化组。跟踪和评价（TE）： CTSI-CN的活动将以周到和详细的评价计划为指导和修改。

After a decade of remarkable research growth and institutional investment, Children's National Medical Center (CNMC) builds on significant strategic recruitments, reorganizations, and collaborations required to create the transformative capabilities of the Clinical and Translational Science Institute at Children's National (CTSI-CN). It has done so in partnership with its academic affiliate, the George Washington University. The specific objectives of our application are to: 1) Provide state-of-the-art, flexible resources required by CTR investigators; 2) Promote multidisciplinary clinical and translational research (CTR); 3) Strengthen CTR education and training for diverse trainees at all stages of career development; 4) Promote demographic diversity and address health disparities; 5) Incorporate effective and sustained collaboration with community partners; 6) Assure efficiency of CTR from conceptualization through dissemination; and 7) Establish bi-directional collaborations with the CTSA network. The CTSI-CN has innovative features including: a child health focus, especially emphasizing health disparities and childhood antecedents of adult diseases; our relationship with a national network of 1200 community health centers, and in TI strengths in rare diseases and neurodevelopmental disabilities. We have combined certain related CTSA components to provide more closely integrated, investigator-focused capabilities. Biomedical Informatics (BI): provides the backbone informatics support to all CTSI-CN components. Research Education, Training and Career Development (RETCD) integrates, supports, and expands CTR education and training so that it is available from high school through mid-career. A new degree program (MS in CTR) and a certificate program are complemented by diverse educational opportunities for faculty, trainees, and staff at all levels of experience. Specialized programs are available for mid-level faculty to promote their career advancement and mentoring capabilities, and for underrepresented minority undergraduates potentially interested in a career in CTR. Community Engagement and Research/Health Policy (CER/HP) integrates traditional community engagement/research with nationally recognized health policy capabilities. Participant and Clinical Interactions Resources (PCIR) transforms our existing GCRC into a nimble and innovative resource that supports participant interactions at diverse locations including CNMC, outpatient facilities, GW, and the community. Pilot and Collaborative Translational and Clinical Studies: supports transformative ideas by investigators at all career levels. Novel Clinical and Translational Methodologies (NCTM) identifies needs and gaps and supports development of innovative methodologies, especially to support TTR cores. Research Design. Epidemiology, Biostatistics, and Clinical Research Ethics/Regulatory Knowledge and Support (DBE/RKS): provides integrated, investigator-focused resources to assure the quality of research and the protection of human subjects at all stages of research. Translational Technologies and Resources (TTR) supports a diverse group of 15 core functions. Tracking and Evaluation (TE): CTSI-CN activities will be guided and modified by a thoughtful and detailed evaluation plan.