Clinical and Translational Science Institute at Children's National

国家儿童医院临床与转化科学研究所

• 批准号: 8473958
• 负责人: LISA MARIE GUAY-WOODFORD
• 金额: $ 337.78万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8473958
• 关键词: Address; Adult; Affect; Biometry; Capital; Child; Child health care; Childhood; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communities; Community Health Centers; Complement; Development; Disadvantaged; Disease; Epidemiology; Evaluation; Faculty; Family; Growth; Health; Health Policy; Informatics; Institutes; Instruction; Investigation; Investments; Knowledge; Location; Medical center; Mentors; Methodology; Modification; Monitor; Neurodevelopmental Disability; Outpatients; Participant; Population; Principal Investigator; Rare Diseases; Research; Research Design; Research Ethics; Research Personnel; Resources; Staging; Technology; Training and Education; Translating; Translational Research; Underrepresented Minority; Universities; Ursidae Family; Vertebral column; Washington; biomedical informatics; career; career development; cost effective; design; experience; flexibility; health disparity; high school; human subject protection; improved; innovation; interest; multidisciplinary; novel; programs; research clinical testing; translational study

Program Director/Principal Investigator (Last, First, Middle): Joseph, Jill G. After a decade of remarkable research growth and institutional investment, Children's National Medical Center (CNMC) builds on significant strategic recruitments, reorganizations, and collaborations required to create the transformative capabilities of the Clinical and Translational Science Institute at Children's National (CTSI-CN). It has done so in partnership with its academic affiliate, the George Washington University. The specific objectives of our application are to: 1) Provide state-of-the-art, flexible resources required by CTR investigators; 2) Promote multidisciplinary clinical and translational research (CTR); 3) Strengthen CTR education and training for diverse trainees at all stages of career development; 4) Promote demographic diversity and address health disparities; 5) Incorporate effective and sustained collaboration with community partners; 6) Assure efficiency of CTR from conceptualization through dissemination; and 7) Establish bi-directional collaborations with the CTSA network. The CTSI-CN has innovative features including: a child health focus, especially emphasizing health disparities and childhood antecedents of adult diseases; our relationship with a national network of 1200 community health centers, and in TI strengths in rare diseases and neurodevelopmental disabilities. We have combined certain related CTSA components to provide more closely integrated, investigator-focused capabilities. Biomedical Informatics (BI): provides the backbone informatics support to all CTSI-CN components. Research Education, Training and Career Development (RETCD) integrates, supports, and expands CTR education and training so that it is available from high school through mid-career. A new degree program (MS in CTR) and a certificate program are complemented by diverse educational opportunities for faculty, trainees, and staff at all levels of experience. Specialized programs are available for mid-level faculty to promote their career advancement and mentoring capabilities, and for underrepresented minority undergraduates potentially interested in a career in CTR. Community Engagement and Research/Health Policy (CER/HP) integrates traditional community engagement/research with nationally recognized health policy capabilities. Participant and Clinical Interactions Resources (PCIR) transforms our existing GCRC into a nimble and innovative resource that supports participant interactions at diverse locations including CNMC, outpatient facilities, GW, and the community. Pilot and Collaborative Translational and Clinical Studies: supports transfomiative ideas by investigators at all career levels. Novel Clinical and Translational Methodologies (NCTM) identifies needs and gaps and supports development of innovative methodologies, especially to support TTR cores. Research Design. Epidemiology, Biostatistics, and Clinical Research Ethics/Regulatory Knowledge and Support (DBE/RKS): provides integrated, investigator-focused resources to assure the quality of research and the protection of human subjects at all stages of research. Translational Technologies and Resources (TTR) supports a diverse group of 15 core functions. Tracking and Evaluation (TE): CTSI-CN activities will be guided and modified by a thoughtful and detailed evaluation plan. RELEVANCE (See Instructions): The CTSI-CN provides highly integrated, cost effective, investigator-focused resources designed to overcome obstacles to investigation, promote collaborative research, and be continuously monitored and evaluated to identify when further adaptation or modification is needed. Located in the nation's capital and serving a population of children and families disproportionately affected by health disparities, the CTSI-CN brings to bear unique resources in translating discovery to improved health, particularly in our most disadvantaged populations of children.

项目主任/首席调查员(最后、第一、中间)：约瑟夫、吉尔·G 经过十年显著的研究增长和机构投资，国家儿童医学中心 (CNMC)以重大战略招聘、重组和协作为基础，创建 国家儿童临床与转化科学研究所(CTSI-CN)的变革能力。 它是与其学术附属机构乔治华盛顿大学合作做到这一点的。具体的 我们申请的目标是：1)为CTR调查人员提供最先进、灵活的资源； 2)促进多学科临床和转化研究(CTR)；3)加强CTR教育和 在职业发展的所有阶段对不同的受训人员进行培训；4)促进人口多样性并解决 健康差距；5)纳入与社区合作伙伴的有效和持续合作；6)确保 CTR从概念化到传播的效率；以及7)建立双向合作 与CTSA网络合作。CTSI-CN具有创新特征，包括：关注儿童健康，特别是 强调健康差距和儿童时期成人疾病的先兆；我们与国家 由1200个社区卫生中心组成的网络，以及TI在罕见疾病和神经发育方面的优势 残疾人士。我们结合了某些相关的CTSA组件，以提供更紧密的集成、 以调查员为中心的能力。生物医学信息学(BI)：为所有 CTSI-CN组件。研究教育、培训和职业发展(RETCD)相结合， 支持和扩展CTR教育和培训，以便从高中到职业生涯中期都可以使用。 一个新的学位计划(CTR硕士)和一个证书计划与不同的教育相补充 为所有经验层次的教职员工、实习生和工作人员提供机会。有专门的计划可用于 中级教员，以促进他们的职业发展和指导能力，并用于任职人数不足的 有兴趣从事CTR职业的少数族裔本科生。社区参与和 研究/健康政策(CER/HP)将传统的社区参与/研究与国家 公认的健康政策能力。参与者和临床互动资源(PCIR)改变了我们的 将现有的GCRC转变为灵活的创新资源，支持不同地点的参与者互动 包括CNMC、门诊设施、GW和社区。试点和协作翻译和 临床研究：支持所有职业层次的研究人员转变想法。新的临床和 翻译方法(NCTM)确定需求和差距，并支持开发创新的 方法，特别是支持TTR核心。研究设计。流行病学、生物统计学和临床 研究伦理/监管知识和支持(DBE/RKS)：提供以研究人员为中心的综合研究 确保研究质量和在研究的所有阶段保护人类受试者的资源。 翻译技术和资源(TTR)支持15个核心功能的不同组。跟踪和 评价(TE)：CTSI-CN的活动将由深思熟虑和详细的评价计划指导和修改。 相关性(请参阅说明)： CTSI-CN提供高度集成、经济高效、以调查人员为重点的资源，旨在克服 阻碍调查，促进合作研究，并被持续监测和评估 确定何时需要进一步调整或修改。位于国家首都，为一名 儿童和家庭人口受到不成比例的健康差距的影响，CTSI-CN将 在将发现转化为改善健康方面的独特资源，特别是在我们最不利的环境中 成群的儿童。