CTSA INFRASTRUCTURE FOR AIDS RESEARCH

该子项目是对CTSA供资的百分比的估计， 用于广泛的研究领域（艾滋病研究，儿科研究，或 临床试验）。 列出的总成本仅为CTSA金额的估算 基础设施走向这一领域的研究，而不是直接提供资金， 向子项目或子项目工作人员提供NCRR补助金。 随着科学景观的兴奋，在基因组学，再生医学，衰老和思想等领域，从来没有一个更有利的时机来利用机会重新设计一个中心，加速发现和促进教育，这将改善健康。斯克里普斯回应了这一背景，并负责一个创造性的基础设施，旨在实现转型，采用创新的战略，杂交的基础和临床计划和前所未有的机构承诺。斯克里普斯翻译科学研究所（STSI）将强调翻译的三个方面：（1）传统，长凳到床边，（2）床边到长凳，回到床边，（3）床边到社区和医学实践。STSI利用今天科学进步的兴奋来推动明天的预防。改善健康和培养未来的学术医学领导者。我们计划的愿景提供了“整合与创新”的适当组合，以及利用美国最大的生物医学研究所斯克里普斯研究所（TSRI）的特殊优势的绝佳机会，以及合作机构和教师，这些机构和教师导致了STSI的4个过度目标的发展（4 T“）。(1)发扬高度负责的跨学科研究的发现精神，结合翻译，临床和社区为基础的调查"（2）培训学员。通过创新的课程和学习经验，不仅促进科学生产力，而且促进专门的转化研究和教育职业道路;（3）通过建立现有的计划，整合TSRI和Scripps Health以及社区合作机构的努力，追求圣地亚哥人口前所未有的参与;以及（4）基础设施和信息学建设：加强和加速该计划的雄心勃勃的需求。与未完成的NCRR平行，|美国国立卫生研究院支持斯克里普斯，斯克里普斯卫生系统提供了一个巨大的，前所未有的投资，充分|证明其优先考虑和愿意承担风险，以促进提高学术转型。建立j和建立真正的，具体的合作，与领先的翻译科学研究人员在0.5英里的枢纽N，托里松树路大大丰富了STSI的成功的学术能力。此外，与圣地亚哥550家生命科学公司中的一大部分公司合作，为获得创新技术和促进患者受益提供了非凡的优势圣地亚哥丰富的生命科学真正受到了STSI的激励。凭借重新设计的基础设施和增强的可塑性，STSI完全准备好通过其占主导地位的医疗保健系统和完善的社区教育和研究计划来接触非常庞大和多样化的圣地亚哥人口，这些计划一直专注于代表性不足的少数民族。STSI将对改善医学和培训未来的医生-研究者领导人产生实质性影响。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. With the excitement of the scientific landscape, in such areas as genomics, regenerative medicine, aging and the mind, there has never been a more favorable time to harness the opportunity to re-engineer a center, accelerate discoveries and foster education which will improve health. Scripps has responded to this backdrop and charge with a creative infrastructure that is intended to achieve transformation employing innovative strategies to hybridize the basic and clinical programs and unprecedented institutional commitments. The Scripps Translational Science Institute (STSI) will emphasize three dimensions of translation: (1) traditional , bench to bedside, (2) bedside to bench and back to bedside, and (3) bedside to the community and practice of medicine. STSI exploits the excitement of today's scientific advances to catapult tomorrow's preventions,. betterment of health, and the training of the future leaders of academic medicine. The vision of our program provides the appropriate amalgam of "integration and innovation," and the remarkable opportunity to capitalize on particular strengths at The Scripps Research Institute (TSRI), the largest biomedical research institute in the United States, and partnering institutions and faculty that have led to the development of 4 over-arching goals of the STSI (the 4 Ts").(1) Ignite the spirit of discovery of highlyrcharged interdisciplinary research, coupling translational, clinical and community-based investigation'(2) Inspire trainees . and young faculty through innovative curriculum and learning experiences, promoting not only scientific productivity but dedicated translational research and education career paths; (3) Integrate the efforts at TSRI and Scripps Health and partnering institutions in the community by building on existing programs, in the pursuit I of unprecedented engagement of the population of San Diego; and (4) Infrastructure and informatics buildup to ': potentiate and accelerate the ambitious needs of the program. Parallel to the outstanding NCRR and overall | NIH support to Scripps, the Scripps Health system has provided a massive, unprecedented investment that fully | certifies its priority and willingness to take on risk to promote heightened academic transformation. Building j upon and establishing genuine, specific collaborations with leading translational science investigators in a 0.5 mile hub on N, Torrey Pines Rd has greatly enriched the academic capabilities for STSI's success. Furthermore, collaborations with a large subset of the 550 life science companies in San Diego provide an , extraordinary advantage for accessing innovative technology and catalyzing patient benefitSan Diego's rich life science has truly been galvanized by STSI. By virtue of the re-engineered infrastructure and enhanced plasticity, STSI is perfectly poised to access the very large and diverse San Diego population through its dominant health care system and well established community education and research programs that have consistently focused on under-represented minorities. STSI will have a substantive impact on improving medicine and training physician-investigator leaders for the future.