BRAIN AGING

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 这个项目是对人类、黑猩猩和其他非人类灵长类动物的正常和病理性脑老化进行比较研究，具体目标是了解为什么人类是唯一患有阿尔茨海默氏症的灵长类动物。我们正在使用比较神经成像来识别不同年龄段的大脑灰质体积、白质体积和白质完整性的物种差异和相似性。此外，我们还比较了大脑显微解剖和死后组织中分子生物学与年龄相关的变化。这包括记录人类和非人类灵长类动物中的β-淀粉样寡糖体的种类，包括人类特有的形式，以及识别结合人类特有形式的配体。2010年，我们完成并发表了一项关于黑猩猩与人类皮质脊髓束不对称性的研究。此外，我们还完成了基于MRI数据的视神经、胼胝体和大脑主要白质束衰老对比研究的数据分析，并启动了白质高信号的对比研究。此外，我们还完成了两个黑猩猩中风病例的组织学和MRI分析。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project is a comparative study of normal and pathological brain aging in humans, chimpanzees, and other nonhuman primates, with the specific goal of understanding why humans are the only primates that develop Alzheimer's disease. We are using comparative neuroimaging to identify species differences and similarities in brain gray matter volume, white matter volume, and white matter integrity across age groups. In addition, we are comparing age-related changes in microscopic brain anatomy and molecular biology in postmorten tissue. This includes documenting the varieties of beta-amyloid oligomes in humans and nonhuman primates, including forms specific to humans, and identifying ligands that bind human-specific forms. In 2010, we completed and published a study of asymmetries in the corticospinal tract of chimpanzees compared to humans. In addition, we completed data analysis of comparative studies of aging in the optic nerves, corpus callosum, and major cerebral white matter tract, based on MRI data, and initiated a comparative study of white-matter hyperintensities. Also, we completed histological and MRI analysis of two chimpanzee stroke cases.