BRAIN AGING

大脑老化

• 批准号: 8357461
• 负责人: TODD M PRUESS
• 金额: $ 3.29万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357461
• 关键词: Aging; Alzheimer' s Disease; Amyloid beta-Protein; Anatomy; Brain; Cerebrum; Comparative Study; Corpus Callosum; Corticospinal Tracts; Data; Data Analyses; Funding; Goals; Grant; Human; Ligand Binding; Magnetic Resonance Imaging; Microscopic; Molecular Biology; National Center for Research Resources; Optic Nerve; Pan Genus; Primates; Principal Investigator; Publishing; Research; Research Infrastructure; Resources; Source; Stroke; Tissues; United States National Institutes of Health; age group; age related; aging brain; base; comparative; cost; gray matter; neuroimaging; nonhuman primate; species difference; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project is a comparative study of normal and pathological brain aging in humans, chimpanzees, and other nonhuman primates, with the specific goal of understanding why humans are the only primates that develop Alzheimer's disease. We are using comparative neuroimaging to identify species differences and similarities in brain gray matter volume, white matter volume, and white matter integrity across age groups. In addition, we are comparing age-related changes in microscopic brain anatomy and molecular biology in postmorten tissue. This includes documenting the varieties of beta-amyloid oligomes in humans and nonhuman primates, including forms specific to humans, and identifying ligands that bind human-specific forms. In 2010, we completed and published a study of asymmetries in the corticospinal tract of chimpanzees compared to humans. In addition, we completed data analysis of comparative studies of aging in the optic nerves, corpus callosum, and major cerebral white matter tract, based on MRI data, and initiated a comparative study of white-matter hyperintensities. Also, we completed histological and MRI analysis of two chimpanzee stroke cases.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 该项目是对人类、黑猩猩和其他非人类灵长类动物的正常和病理性脑老化的比较研究，具体目标是了解为什么人类是唯一患阿尔茨海默病的灵长类动物。 我们正在使用比较神经影像学来确定不同年龄组的脑灰质体积、白色物质体积和白色物质完整性的物种差异和相似性。 此外，我们正在比较死后组织中显微脑解剖学和分子生物学的年龄相关变化。 这包括记录人类和非人灵长类动物中β-淀粉样蛋白寡聚体的种类，包括人类特有的形式，并鉴定结合人类特异性形式的配体。 2010年，我们完成并发表了一项关于黑猩猩与人类皮质脊髓束不对称性的研究。 此外，我们完成了基于MRI数据的视神经、胼胝体和主要大脑白色束的老化比较研究的数据分析，并启动了白质高信号的比较研究。 此外，我们完成了两个黑猩猩中风病例的组织学和MRI分析。