RESTING STATE FUNCTIONAL CONNECTIVITY IN CHIMPANZEES

黑猩猩静息态功能连接

• 批准号: 8172373
• 负责人: TODD M PRUESS
• 金额: $ 2.74万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172373
• 关键词: Behavioral; Brain; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Evolution; Functional Magnetic Resonance Imaging; Funding; Grant; Human; Institution; Knowledge; Light; Pan Genus; Reporting; Research; Research Personnel; Resources; Rest; Scanning; Source; Techniques; United States National Institutes of Health; Weight; Work

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. fMRI has been used to detect functionally connected networks in the resting human brain. Because these networks are present both at rest and also in the lightly anesthetized state, it is possible to identify them in lightly anesthetized chimpanzees and compare them with those found in humans to inform our knowledge of the extent to which human and chimpanzee brains are similarly organized. This may help us to identify specializations of human brain connectivity that support human cognitive and behavioral specializations and will also shed light on human brain evolution. During the reporting period, we worked out techniques for correct distortions in the T2*-weighted scans so as to register them accurately to the anatomical T1 scans. In addition, we began studies of connectivity in chimpanzees by seeding selected regions of cortex and identifying territories that show correlated activity.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 功能磁共振成像已被用于检测休息中的人脑中功能连接的网络。由于这些网络在休息时和轻度麻醉状态下都存在，因此有可能在轻度麻醉的黑猩猩中识别出它们，并将它们与人类中发现的网络进行比较，以告知我们人类和黑猩猩大脑组织相似程度的知识。 这可能有助于我们识别支持人类认知和行为专业化的人类大脑连接的专业化，也将揭示人类大脑的进化。在本报告所述期间，我们制定了纠正T2* 加权扫描失真的技术，以便将其准确地与解剖T1扫描配准。 此外，我们开始研究黑猩猩的连通性，方法是在选定的皮层区域植入种子，并识别出显示相关活动的区域。