RESTING STATE BRAIN ACTIVITY IN CHIMPANZEES

黑猩猩静息状态下的大脑活动

• 批准号: 7958241
• 负责人: TODD M PRUESS
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958241
• 关键词: Animals; Area; Brain; Cognitive; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Home environment; Human; Human Activities; Institution; Judgment; Language; Left; Magnetic Resonance Imaging; Medial; Memory; Monitor; Pan Genus; Parietal; Positron-Emission Tomography; Primates; Reporting; Research; Research Personnel; Resources; Rest; Source; United States National Institutes of Health; awake; social; social cognition; uptake

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. PET and MRI have been used to monitor functional activity of the human brain in subjects awake, but at rest. These studies have demonstrated that certain cortical regions known to be activated when subjects engage in social cognition tasks and introspection. We monitored resting cognitive brain activity in chimpanzees using FDG-PET. FDG was administered orally while the animal is resting in its home enclosure; after an appropriate uptake period, the animals were anesthetized and given a PET scan. During the reporting period, our results indicated that chimpanzees and humans activate many of the same cortical areas at rest, specifically, the medial frontal and medial parietal/posterior cingulate areas involved in social judgement and recollection of personal memories. Only humans, however, show left-lateralized activity in frontal and temporoparietal regions associated with language.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 PET和MRI已被用于监测清醒但休息的受试者的人脑的功能活动。 这些研究表明，当受试者参与社会认知任务和内省时，某些皮质区域被激活。 我们使用FDG-PET监测黑猩猩的静息认知脑活动。 当动物在其家庭围栏中休息时，口服给予FDG;在适当的摄取期后，将动物麻醉并进行PET扫描。 在本报告所述期间，我们的研究结果表明，黑猩猩和人类在休息时激活了许多相同的皮层区域，特别是内侧额叶和内侧顶叶/后扣带回区域，这些区域涉及社会判断和个人记忆的回忆。 然而，只有人类在与语言相关的额叶和颞顶区域显示出左侧活动。