BRAIN AGING

大脑老化

• 批准号: 8172413
• 负责人: TODD M PRUESS
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172413
• 关键词: Alzheimer' s Disease; Amyloid beta-Protein; Anatomy; Brain; Comparative Study; Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Human; Institution; Ligand Binding; Microscopic; Molecular Biology; Pan Genus; Primates; Research; Research Personnel; Resources; Source; Tissues; United States National Institutes of Health; age group; age related; aging brain; comparative; gray matter; neuroimaging; nonhuman primate; species difference; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project is a comparative study of normal and pathological brain aging in humans, chimpanzees, and other nonhuman primates, with the specific goal of understanding why humans are the only primates that develop Alzheimer's disease. We are using comparative neuroimaging to identify species differences and similarities in brain gray matter volume, white matter volume, and white matter integrity across age groups. In addition, we are comparing age-related changes in microscopic brain anatomy and molecular biology in postmorten tissue. This includes documenting the varieties of beta-amyloid oligomes in humans and nonhuman primates, including forms specific to humans, and identifying ligands that bind human-specific forms.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目是对人类，黑猩猩和其他非人类灵长类动物的正常和病理大脑衰老的比较研究，其具体目标是理解为什么人类是唯一发展阿尔茨海默氏病的灵长类动物。 我们正在使用比较神经影像来确定脑灰质体积，白质体积和白质完整性的物种差异和相似性。 此外，我们正在比较术后组织中与年龄相关的微观脑解剖结构和分子生物学的变化。 这包括记录人类和非人类灵长类动物中的β-淀粉样蛋白寡聚的品种，包括人类特定的形式，并识别结合人类特异性形式的配体。