FUNCTIONAL ORGANIZATION OF AUDITORY CORTEX

听觉皮层的功能组织

• 批准号: 8357466
• 负责人: TODD M PRUESS
• 金额: $ 4.12万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8357466
• 关键词: Animals; Area; Auditory area; Cell Nucleus; Diffusion Magnetic Resonance Imaging; Evolution; Fiber; Funding; Grant; Histological Techniques; Human; Immunohistochemistry; Label; Macaca; Medial; Monkeys; National Center for Research Resources; Pan Genus; Pattern; Primates; Principal Investigator; Research; Research Infrastructure; Resources; Sensory; Source; Thalamic structure; United States National Institutes of Health; area striata; cost; experience; immunoreactivity; neuroimaging

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project seeks to understand the organization of auditory cortex in humans and the evolution of human-specific features of auditory cortex by comparing humans with chimpanzees (the animals most closely related to humans) and in macaque monkeys. The project will use neuroimaging and histological techniques to define higher-order auditory areas in humans, identify homologous areas in chimpanzees and macaques, and determine patterns of connectivity between auditory areas in the three species. In 2010, we developed experience with immunohistochemistry for vesicular glumate transporter 2 (VGLUT2), which has been posited to serve as a specific marker for cortical afferents arising from thalamic sensory nuclei. To confirm this, we examined VGLUT2 immunoreactivity in primary visual cortex from 3 species (humans, chimpanzees, and macaque monkeys) that are believed to differ in the laminar targets of geniculate projections. The results with VGLUT2 strongly support the idea that this transporter can serve as a marker for primary sensory thalamocortical afferents. We have now begun to label auditory cortex with anti-VGLUT to better understand the distribution of medial geniculate projections to this region. In addition, we have initiated a study of the distribution of medial geniculate fibers in the auditory cortex in chimpanzees using diffusion-tensor imaging.

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 本项目通过比较人类与黑猩猩（与人类关系最密切的动物）和猕猴，来了解人类听觉皮层的组织结构和人类特有的听觉皮层特征的演变。 该项目将使用神经成像和组织学技术来定义人类的高阶听觉区域，识别黑猩猩和猕猴的同源区域，并确定这三个物种听觉区域之间的连接模式。 2010年，我们开发了囊泡谷氨酸转运蛋白2（VGLUT 2）的免疫组织化学经验，该转运蛋白2被认为是丘脑感觉核产生的皮质传入的特异性标记物。 为了证实这一点，我们研究了VGLUT 2免疫反应在初级视觉皮层从3个物种（人类，黑猩猩，猕猴），被认为是不同的膝状体预测的层状目标。 VGLUT 2的结果强烈支持这种转运蛋白可以作为初级感觉丘脑皮质传入的标记物的想法。 我们现在已经开始用anti-VGLUT标记听觉皮层，以更好地了解内侧膝状体投射到该区域的分布。 此外，我们已经开始使用扩散张量成像的黑猩猩听觉皮层内侧膝状体纤维的分布的研究。